HDC gene polymorphisms are associated with age at natural menopause in Caucasian women.

abstract：:It has been proposed that the estrogen receptor bears proteolytic activity responsible for its own transformation. This activity was inhibited by aprotinin. Incubation of transformed ER with aprotinin modified the proteolytic digestion of the hormone binding subunit by proteinase K. The smallest hormone-binding fragme...

journal_title：Biochemical and biophysical research communications

authors： Nigro V,Medici N,Abbondanza C,Minucci S,Moncharmont B,Molinari AM,Puca GA

更新日期：1990-07-31 00:00:00

abstract：:Biochemical properties of bovine lactoperoxidase isolated from milk and recombinant bovine lactoperoxidase expressed by Chinese hamster ovary cells were compared. The natural and recombinant lactoperoxidases showed the same conformational features as determined by circular dichroism (CD) measurements. The alpha-helix,...

journal_title：Biochemical and biophysical research communications

authors： Watanabe S,Murata S,Kumura H,Nakamura S,Bollen A,Moguilevsky N,Shimazaki K

更新日期：2000-08-11 00:00:00

abstract：:Taking advantage of the defined acceptor specificity of rat liver alpha 2,6-sialyltransferase, N-linked Gal beta 1,4GlcNAc-sequences of glycoconjugates at the plasma membrane of viable human erythrocytes and lymphoblastic IM-9 cells were modified to terminate in three NeuAc analogues endowed with special biochemical p...

journal_title：Biochemical and biophysical research communications

authors： Kosa RE,Brossmer R,Gross HJ

更新日期：1993-02-15 00:00:00

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:Cysteine proteases and matrix metalloproteinases (MMPs) are important factors in the degradation of organic matrix components of bone. Osteoprotegerin (OPG) is an osteoblast-secreted decoy receptor that inhibits osteoclast differentiation and activation. This study investigated the direct effects of human OPG on cathe...

journal_title：Biochemical and biophysical research communications

authors： Wittrant Y,Couillaud S,Theoleyre S,Dunstan C,Heymann D,Rédini F

更新日期：2002-04-26 00:00:00

abstract：:Three different domains of human sperm membrane, viz., the hydrophobic domains, the aqueous compartments and the surface proteins were probed to evaluate the molecular dynamics in these microenvironments in normal as well as oligospermic cases. Decreased rotational motion of the stearic spin-labels, designated rigid l...

journal_title：Biochemical and biophysical research communications

authors： Sinha S,Kumar GP,Laloraya M

更新日期：1994-01-14 00:00:00

abstract：:The human histiocyte cell line, U937, with monocyte characteristics, can be induced to differentiate into macrophage-like cells when exposed to growth medium containing 1.5% DMSO. Following three days of exposure, DMSO-treated but not control U937 cells can be stimulated to release endogenous arachidonic acid from the...

journal_title：Biochemical and biophysical research communications

authors： Myers RF,Siegel MI

更新日期：1984-01-13 00:00:00

abstract：:We have cloned and functionally expressed a sodium-dependent human nucleoside transporter, hCNT2, from a CNS cancer cell line U251. Our cDNA clone of hCNT2 had the same predicted amino acid sequence as the previously cloned hCNT2 transporter. Of the several cell lines studied, the best hCNT2 transport function was obt...

journal_title：Biochemical and biophysical research communications

authors： Shin HC,Landowski CP,Sun D,Vig BS,Kim I,Mittal S,Lane M,Rosania G,Drach JC,Amidon GL

更新日期：2003-08-01 00:00:00

abstract：:Two novel alpha-neurotoxins, Oh-6A and Oh-6B, isolated from the king cobra (Ophiophagus hannah) venom, consist of 70 amino acid residues with 10 cysteine residues and share the same amino acid sequences as determined by Edman degradation on the peptide fragments generated from the proteolytic hydrolysates. Their seque...

journal_title：Biochemical and biophysical research communications

authors： Lin SR,Chang LS,Chang CC

更新日期：1999-01-08 00:00:00

abstract：:Using PAGE--Autoradioblotting technique we have characterized an E--FABP in human epidermal cells that is distinct from liver-, heart-, intestine- and adipose tissue-FABPs. FABP radiobinding analysis was performed directly on protein extracts without prior partial purification. E-FABP has a Mr of approximately 15 kDa ...

journal_title：Biochemical and biophysical research communications

authors： Siegenthaler G,Hotz R,Chatellard-Gruaz D,Jaconi S,Saurat JH

更新日期：1993-01-29 00:00:00

abstract：:Ghrelin is a peptide found in the hypothalamus and stomach that stimulates food intake and whose circulating concentrations are affected by nutritional state. Very little is known about other central behavioral effects of ghrelin, and thus, we investigated the effects of ghrelin on anxiety and memory retention. The pe...

journal_title：Biochemical and biophysical research communications

authors： Carlini VP,Monzón ME,Varas MM,Cragnolini AB,Schiöth HB,Scimonelli TN,de Barioglio SR

更新日期：2002-12-20 00:00:00

abstract：:A protein, with a novel N-terminal amino acid sequence and a molecular mass of 30 kDa, was purified from fresh Smilax glabra rhizomes by adsorption on DEAE-cellulose, CM-cellulose, Con A-Sepharose, and Mono S, and by fast protein liquid chromatography-gel filtration on Superdex 75. The protein, designated as smilaxin,...

journal_title：Biochemical and biophysical research communications

authors： Chu KT,Ng TB

更新日期：2006-02-03 00:00:00

abstract：:Chromatin spatial organization is essential for transcriptional modulation and stabilization. The pattern of DNA distal interplay form the multiple topological associating domains (TADs), and further assemble the functional compartmentalization with open and expression-active chromatin ("A" compartments) or closed and...

journal_title：Biochemical and biophysical research communications

authors： Gong W,Liu Y,Qu H,Liu A,Sun P,Wang X

更新日期：2019-03-19 00:00:00

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:Using a culture system that facilitates osteogenic differentiation of bone marrow-derived human mesenchymal stem cells, we analyzed gene-expression profiles during the mineralization process by means of a cDNA microarray system consisting of 23,040 genes. We compared expression profiles of the cells at days 3, 15, and...

journal_title：Biochemical and biophysical research communications

authors： Doi M,Nagano A,Nakamura Y

更新日期：2002-01-11 00:00:00

abstract：:A novel photoaffinity label, 8-N(3)-3'-biotinyl-ATP, has been synthesized. The introduction of an additional biotin residue is advantageous for easy detection of labeled proteins. This could be first tested by reaction with the F(1)-ATPase from the thermophilic bacterium PS3 (TF(1)). UV irradiation of TF(1) in the pre...

journal_title：Biochemical and biophysical research communications

authors： Schäfer HJ,Coskun U,Eger O,Godovac-Zimmermann J,Wieczorek H,Kagawa Y,Grüber G

更新日期：2001-09-07 00:00:00

abstract：:We report here on the cloning and functional characterization of human LAT1, a subunit of the amino acid transport system L. The hLAT1 cDNA, obtained from a human placental cDNA library, codes for a protein of 507 amino acids. When functionally expressed in mammalian cells together with the heavy chain of the rat 4F2 ...

journal_title：Biochemical and biophysical research communications

authors： Prasad PD,Wang H,Huang W,Kekuda R,Rajan DP,Leibach FH,Ganapathy V

更新日期：1999-02-16 00:00:00

abstract：:Free radicals attack lipid molecules and initiate a chain of reactions that may trigger several diseases such as atherosclerosis and cancer. Several markers of oxidative stress have been proposed, including measurements of lipid peroxides and short-chain aldehydes levels and evaluation of conjugated diene formation. A...

journal_title：Biochemical and biophysical research communications

authors： Visioli F,Colombo C,Galli C

更新日期：1998-04-17 00:00:00

abstract：:Hippo pathway regulates cell proliferation and differentiation. Yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) are effectors of Hippo pathway. The function of Yap/Taz in embryonic liver development has yet to be reported. Here yap1 and taz were found expressed in liver and ot...

journal_title：Biochemical and biophysical research communications

authors： Yi X,Yu J,Ma C,Li L,Luo L,Li H,Ruan H,Huang H

更新日期：2018-09-03 00:00:00

abstract：:Liraglutide, a glucagon-like peptide 1 (GLP-1) analogue, could reverse NAFLD-induced liver damage by improving metabolic profiles, but the exact molecular mechanism has not been elucidated. Sestrin2 is a novel antioxidant protein, essential for regulating metabolic homeostasis. However, whether sestrin2-mediated redox...

journal_title：Biochemical and biophysical research communications

authors： Han X,Ding C,Zhang G,Pan R,Liu Y,Huang N,Hou N,Han F,Xu W,Sun X

更新日期：2020-05-14 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a well-defined genetic p...

journal_title：Biochemical and biophysical research communications

authors： Li X,Guo L,Liu Y,Su Y,Xie Y,Du J,Zhou J,Ding G,Wang H,Bai Y,Liu Y

更新日期：2017-11-18 00:00:00

abstract：:Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation. Its primary structure is identical to co-chaperone p23, a heat shock protein 90 (Hsp90)-binding protein. We have revealed that Hsp90 regulated both cP...

journal_title：Biochemical and biophysical research communications

authors： Nakatani Y,Hokonohara Y,Kakuta S,Sudo K,Iwakura Y,Kudo I

更新日期：2007-10-19 00:00:00

abstract：:Activation of mouse cytotoxic T lymphocytes (CTL) with target cells expressing antigen resulted in the release of serine esterase (SE) into the culture supernatant. Short term treatment (3 hr) of CTL with phorbol-12-myristate-13-acetate (PMA) plus ionophore also caused stimulation of SE release from CTL, while neither...

journal_title：Biochemical and biophysical research communications

authors： Nishimura T,Ito T

更新日期：1987-08-14 00:00:00

abstract：:Phosphate is essential for cell metabolism in all organisms. As it is often limiting in the soil, plants have evolved various mechanisms to cope with low-phosphate conditions. Here, we report that Aluminum Sensitive 3 and NAP3, two genes previously identified to function in aluminum tolerance, play a critical role in ...

journal_title：Biochemical and biophysical research communications

authors： Belal R,Tang R,Li Y,Mabrouk Y,Badr E,Luan S

更新日期：2015-07-17 00:00:00

abstract：:As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoc...

journal_title：Biochemical and biophysical research communications

authors： Thorlacius H,Raud J,Rosengren-Beezley S,Forrest MJ,Hedqvist P,Lindbom L

更新日期：1994-09-15 00:00:00

abstract：:The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats wit...

journal_title：Biochemical and biophysical research communications

authors： Axén E,Postlind H,Wikvall K

更新日期：1995-10-04 00:00:00

abstract：:Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in normal cells, contributing to carcinogenesis and various pathological conditions. While cellular senescence arrests the early phase of cell cycle without any detectable telomere loss or dysfunction. ROS is reported to contribute to in...

journal_title：Biochemical and biophysical research communications

authors： Sasaki M,Kajiya H,Ozeki S,Okabe K,Ikebe T

更新日期：2014-09-26 00:00:00

abstract：:The objective of this study was to assess the role of NETs in BPD of hyperoxia-induced rat model and the effect of heparin on alveolarization and vascular development in BPD. The neonatal rats exposed to 90% oxygen continuously for 7 days to mimic BPD, meanwhile, the rats were injected by different doses of histones t...

journal_title：Biochemical and biophysical research communications

authors： Sun Y,Chen C,Zhang X,Wang S,Zhu R,Zhou A,Chen S,Feng J

更新日期：2020-01-29 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is able to sense the availability and quality of nitrogen sources and the intrinsic variation of amino acid disponibility for protein synthesis. When this yeast is provided with secondary nitrogen sources, transcription of genes encoding enzymes involved in their catabolism is elicit...

journal_title：Biochemical and biophysical research communications

authors： Hernández H,Aranda C,Riego L,González A

更新日期：2011-01-21 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00