A new function of Ito cells in liver morphogenesis: evidence using a novel morphogenic protein, epimorphin, in vitro.

Abstract:

:A novel mesenchymal protein, epimorphin, has been reported to play a key role in morphogenesis of fetal organs. The morphological and functional features of epimorphin in adult liver were entirely unknown. This study was performed to determine the distribution and function of this protein in the adult mouse liver. Epimorphin was detected on sinusoidal Ito cells. It played an essential role in the formation of hepatocyte spheroids which maintained differentiated function in primary culture. Therefore, Ito cells might control the differentiation of parenchymal hepatocytes in the adult liver in the pathologic condition as well as in fetal organs.

authors

Hirose M,Watanabe S,Oide H,Kitamura T,Miyazaki A,Sato N

doi

10.1006/bbrc.1996.1146

subject

Has Abstract

pub_date

1996-08-05 00:00:00

pages

155-60

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91146-8

journal_volume

225

pub_type

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