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Effect of gamma-aminobutyric acid on the carnitine metabolism in neural cells.

Abstract：

:Isolated rat cerebral cortex cells were able to accumulate L-carnitine and this process was competitively inhibited by 1 mM gamma-aminobutyric acid (GABA) with a shift of Km from 7.8 +/- 1.9 mM to 14.6 +/- 4.0 mM. Addition of GABA also affected distribution of carnitine derivatives. The decrease of acetylcarnitine level by 1.6 fold was correlated with the inhibition of carnitine acetyltransferase (1.77 times). A postulated involvement of this enzyme in delivering acetyl moieties for acetylcholine synthesis would suggest a negative feedback between GABA and the level of acetylcholine.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wawrzeńczyk A,Nałecz KA,Nałecz MJ

doi

10.1006/bbrc.1995.2143

subject

Has Abstract

pub_date

1995-08-15 00:00:00

pages

383-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72143-2

journal_volume

213

pub_type

杂志文章

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