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MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-catenin.

Abstract：

:Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and underlying mechanisms in the development and progression of colorectal carcinoma has not been elucidated clearly. Here, we performed real-time PCR to examine the expression levels of miR-320a in colon cancer cell lines and tumor tissues. And then, we investigated its biological functions in colon cancer cells by a gain of functional strategy. Further more, by the combinational approaches of bioinformatics and experimental validation, we confirmed target associations of miR-320a in colorectal carcinoma. Our results showed that miR-320a was frequently downregulated in cancer cell lines and colon cancer tissues. And we demonstrated that miR-320a restoration inhibited colon cancer cell proliferation and β-catenin, a functionally oncogenic molecule was a direct target gene of miR-320a. Finally, the data of real-time PCR showed the reciprocal relationship between miR-320a and β-catenin's downstream genes in colon cancer tissues. These findings indicate that miR-320a suppresses the growth of colon cancer cells by directly targeting β-catenin, suggesting its application in prognosis prediction and cancer treatment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sun JY,Huang Y,Li JP,Zhang X,Wang L,Meng YL,Yan B,Bian YQ,Zhao J,Wang WZ,Yang AG,Zhang R

doi

10.1016/j.bbrc.2012.03.075

subject

Has Abstract

pub_date

2012-04-20 00:00:00

pages

787-92

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00535-9

journal_volume

420

pub_type

杂志文章

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