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Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis.

Abstract：

:Mycoplasma fermentans has been suspected as one of the causative pathogenic microorganisms of rheumatoid arthritis (RA) however, the pathogenic mechanism is still unclear. We, previously, reported that glycolipid-antigens (GGPL-I and III) are the major antigens of M. fermentans. Monoclonal antibody against the GGPL-III could detect the existence of the GGPL-III antigens in synovial tissues from RA patients. GGPL-III antigens were detected in 38.1% (32/84) of RA patient's tissues, but not in osteoarthritis (OA) and normal synovial tissues. Immunoelectron microscopy revealed that a part of GGPL-III antigens are located at endoplasmic reticulum. GGPL-III significantly induced TNF-alpha and IL-6 production from peripheral blood mononulear cells, and also proliferation of synovial fibroblasts. Further study is necessary to prove that M. fermentans is a causative microorganism of RA; however, the new mechanisms of disease pathogenesis provides hope for the development of effective and safe immunotherapeutic strategies based on the lipid-antigen, GGPL-III, in the near future.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kawahito Y,Ichinose S,Sano H,Tsubouchi Y,Kohno M,Yoshikawa T,Tokunaga D,Hojo T,Harasawa R,Nakano T,Matsuda K

doi

10.1016/j.bbrc.2008.02.079

subject

Has Abstract

pub_date

2008-05-02 00:00:00

pages

561-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00312-4

journal_volume

369

pub_type

杂志文章

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