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C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.

Abstract：

:Two types of natriuretic peptide, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), very similar to each other in structure and in pharmacological effect, are known to be present in mammalian heart and brain. In our present survey for unidentified peptides in porcine brain extracts, we found a new peptide of 22 amino acid residues, eliciting a potent relaxant activity on chick rectum. The amino acid sequence determined for the peptide shows remarkable similarity to those of ANP and BNP, especially in the 17-residue sequences flanked by two cysteine residues. The peptide shows a pharmacological spectrum similar to ANP and BNP. Thus, the peptide was designated "C-type natriuretic peptide (CNP)", the third member to join the natriuretic peptide family. In contrast to ANP and BNP, CNP terminates in the second cysteine residue, lacking a further C-terminal extension.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sudoh T,Minamino N,Kangawa K,Matsuo H

doi

10.1016/0006-291x(90)92401-k

subject

Has Abstract

pub_date

1990-04-30 00:00:00

pages

863-70

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92401-K

journal_volume

168

pub_type

杂志文章

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