Transcriptional activation of SHP by PPAR-gamma in liver.

Abstract:

:The mechanism of how PPARgamma decrease gluconeogenic gene expressions in liver is still unclear. Since PPARgamma is a transcriptional activator, it requires a mediator to decrease the transcription of gluconeogenic genes. Recently, SHP has been shown to mediate the bile acid-dependent down regulation of gluconeogenic gene expression in liver. This led us to explore the possibility that SHP may mediate the antigluconeogenic effect of PPARgamma. In the present study, we have identified and characterized the presence of functional PPRE in human SHP promoter. We show the binding of PPARgamma/RXRalpha heterodimer to the PPRE and increased SHP expression by rosiglitazone in primary rat hepatocytes. Taken together with the previous reports about the function of SHP on gluconeogenesis, our results indicate that SHP can mediate the acute antigluconeogenic effect of PPARgamma.

authors

Kim HI,Koh YK,Kim TH,Kwon SK,Im SS,Choi HS,Kim KS,Ahn YH

doi

10.1016/j.bbrc.2007.05.171

subject

Has Abstract

pub_date

2007-08-24 00:00:00

pages

301-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01098-4

journal_volume

360

pub_type

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