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Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.

Abstract：

:Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease (PD), but its true physiological function remains unknown. In the normal mouse, LRRK2 is expressed in kidney, spleen, and lung at much higher levels than in brain, suggesting that LRRK2 may play an important role in these organs. Analysis of age-related changes in LRRK2 expression demonstrated that expression in kidney, lung, and various brain regions was constant throughout adult life. On the other hand, expression of both LRRK2 mRNA and protein decreased markedly in spleen in an age-dependent manner. Analysis of purified spleen cells indicated that B lymphocytes were the major population expressing LRRK2, and that T lymphocytes showed no expression. Consistently, the B lymphocyte surface marker CD19 exhibited an age-dependent decrease of mRNA expression in spleen. These results suggest a possibly novel function of LRRK2 in the immune system, especially in B lymphocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Maekawa T,Kubo M,Yokoyama I,Ohta E,Obata F

doi

10.1016/j.bbrc.2010.01.041

subject

Has Abstract

pub_date

2010-02-12 00:00:00

pages

431-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00071-9

journal_volume

392

pub_type

杂志文章

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