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Defective GATA-3 expression in Th2 LCR-deficient mice.

Abstract：

:Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells. GATA-3 and STAT6 bound several regulatory regions in the gata3 locus and transactivated the expression of the gata3 gene. These results suggest that Th2 differentiation program stimulates feed-forward regulation of gata3 gene expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hwang SS,Kim K,Lee GR

doi

10.1016/j.bbrc.2011.06.080

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

866-71

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)01053-9

journal_volume

410

pub_type

杂志文章

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