Selective enhancement of the induction of alpha-lactalbumin activity in rat mammary explants by epidermal growth factor.

abstract：:It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT(3)) receptor to cause nausea and vomiting. In general, antagonist for 5-HT(3) receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinoteca...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ishida Y,Yamada T,Shimada S

更新日期：2011-11-18 00:00:00

abstract：:Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part of the DNA-end binding complex, required for proper maintenance of telomeres and contributes to DNA damage recognition and regulation of apoptosis. Forces that r...

journal_title：Biochemical and biophysical research communications

authors： Yurchenko V,Xue Z,Gama V,Matsuyama S,Sadofsky MJ

更新日期：2008-02-01 00:00:00

abstract：:Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, but the potential role of cholesterol in the progression of HCC remains controversial. In the present study,we tested the i...

journal_title：Biochemical and biophysical research communications

authors： Zhao Z,Zhong L,He K,Qiu C,Li Z,Zhao L,Gong J

更新日期：2019-02-19 00:00:00

abstract：:Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporo-spatial manner. The zinc-finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regu...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Zhu C,Luo J,Wang Y,Li D,Li Y,Zhou J,Yuan W,Ou Y,Liu M,Wu X

更新日期：2004-07-16 00:00:00

abstract：:Sensitization to Cupressaceae pollen has become one of the most important causes of pollinosis in Western countries during winter and early spring. However, the characterization of the extracts, the allergens involved and the cross-reactivity with other pollen sources still remain poorly studied; in the case of Cupres...

journal_title：Biochemical and biophysical research communications

authors： Pico de Coaña Y,Parody N,Fuertes MÁ,Carnés J,Roncarolo D,Ariano R,Sastre J,Mistrello G,Alonso C

更新日期：2010-10-22 00:00:00

abstract：:These studies sought to determine the intracellular mechanisms underlying muscarinic receptor stimulated phasic contractions of myometrial smooth muscle. Utilizing cytosolic calcium imaging studies with Fura-2 loaded muscle strips, along with in vitro isometric contraction studies, we have demonstrated that phasic myo...

journal_title：Biochemical and biophysical research communications

authors： Phillippe M,Basa A

更新日期：1997-02-24 00:00:00

abstract：:The molecular sizes of histamine H1-receptors of rat, rabbit, human, pig, guinea-pig, chicken, dog, and bovine liver were investigated by radiation inactivation and determined to be 100,000 to 160,000 daltons in all the animals examined. Statistical analysis showed that the hepatic H1-receptors have a common size of 1...

journal_title：Biochemical and biophysical research communications

authors： Wang NP,Fukui H,Matsuoka H,Wada H

更新日期：1986-06-13 00:00:00

abstract：:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each o...

journal_title：Biochemical and biophysical research communications

authors： Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura T

更新日期：1987-10-29 00:00:00

abstract：:Acetyl-CoA carboxylases (ACCs) have been highlighted as therapeutic targets for obesity and diabetes, as they play crucial roles in fatty acid metabolism. ACC activity is regulated through the short-term mechanism of inactivation by reversible phosphorylation. Here, we report the crystal structures of the biotin carbo...

journal_title：Biochemical and biophysical research communications

authors： Cho YS,Lee JI,Shin D,Kim HT,Jung HY,Lee TG,Kang LW,Ahn YJ,Cho HS,Heo YS

更新日期：2010-01-01 00:00:00

abstract：:This paper reports the identification of a Rho family nucleotide exchange factor termed mNET1 as a candidate-interacting partner for the first PDZ domain of MAGI-1, a membrane-associated guanylate kinase with inverted arrangement of protein-protein interacting modules. mNET1 was identified in a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Dobrosotskaya IY

更新日期：2001-05-18 00:00:00

abstract：:Although it is recognized that 4,5-diaminovaleric acid, formed from glutamate 1-semialdehyde, functions as the intermediate in the last step of delta-aminolevulinic acid formation from glutamate, the enantioselectivity of the participating glutamate 1-semialdehyde aminotransferase for 4,5-diaminovaleric acid has remai...

journal_title：Biochemical and biophysical research communications

authors： Friedmann HC,Duban ME,Valasinas A,Frydman B

更新日期：1992-05-29 00:00:00

abstract：:The hspA gene encodes a small heat-shock protein in the thermophilic cyanobacterium Synechococcus vulcanus. To gain insight into the post-transcriptional regulation, hspA was expressed in Escherichia coli. HspA was induced upon a temperature upshift from 30 to 42 degrees C, although the hspA transcription in E. coli o...

journal_title：Biochemical and biophysical research communications

authors： Kojima K,Nakamoto H

更新日期：2005-06-03 00:00:00

abstract：:Artificial DNA binding peptides recognizing separated sequences would expand varieties of the target genes for desirable transcriptional control. Here we demonstrated that polyarginine linker between two 3-zinc finger domains gives DNA binding selectivity to the separated target sequences. We created a six-zinc finger...

journal_title：Biochemical and biophysical research communications

authors： Imanishi M,Yan W,Morisaki T,Sugiura Y

更新日期：2005-07-22 00:00:00

abstract：:Enzymes belonging to the S9 family of prolyl oligopeptidases are of interest because of their pharmacological importance and have a non-catalytic β-propeller domain. In this study, we found that the oxidation of Met203, which lies on surface of the β-propeller domain, leads to change in the substrate specificity of er...

journal_title：Biochemical and biophysical research communications

authors： Tokai S,Bito T,Shimizu K,Arima J

更新日期：2017-05-27 00:00:00

abstract：:Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern...

journal_title：Biochemical and biophysical research communications

authors： Noji S,Matsuo T,Koyama E,Yamaai T,Nohno T,Matsuo N,Taniguchi S

更新日期：1990-04-16 00:00:00

abstract：:The effect of 1-bromlalkanes on intracellular glutathione (GSH) was studied in freshly isolated rat hepatocytes. Treatment of cells with bromoalkanes depleted cellular GSH levels without causing cytotoxicity. The extent of GSH depletion was directly proportional to the concentration and increasing chain length of 1-br...

journal_title：Biochemical and biophysical research communications

authors： Khan S,O'Brien PJ

更新日期：1991-08-30 00:00:00

abstract：:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant...

journal_title：Biochemical and biophysical research communications

authors： Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

更新日期：1984-10-15 00:00:00

abstract：:Two internalizing monovalent single chain antibody fragments (scFv), C6.5 and F5, that recognize distinct ErbB2 extracellular domain (ECD) epitopes, and their bivalent forms dbC6.5 and F5(scFv')(2), were compared to the growth-inhibiting anti-ErbB2 antibody Herceptin/trastuzumab, in either its bivalent (Her) or monova...

journal_title：Biochemical and biophysical research communications

authors： Neve RM,Nielsen UB,Kirpotin DB,Poul MA,Marks JD,Benz CC

更新日期：2001-01-12 00:00:00

abstract：:Estrogen receptor (ER) is regarded as a major causal factor in breast cancer and FoxA1, a winged-helix transcription factor belonging to the forkhead family, has been found to function as a pioneer factor in the recruitment of ER to several cis-regulatory elements in the genome. High throughput chromatin immunoprecipi...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Chen S

更新日期：2010-09-10 00:00:00

abstract：:Previously, we showed that several minor macromolecular glycolipids accounting for less than 5% of the lipoteichoic acid (LTA) fraction from Enterococcus hirae ATCC 9790 possess cytokine-inducing activity, whereas the purified LTA does not. In other words, the immunobiological activity of the LTA fraction reported in ...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Imamura Y,Morichika T,Arimoto K,Takeuchi O,Takeda K,Akira S,Aoyama K,Tamura T,Kotani S,Suda Y,Kusumoto S

更新日期：2000-06-24 00:00:00

abstract：:12-O-tetradecanoyl phorbol 13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol (diC8) activate protein kinase C (PKC) in transformed fetal bovine aortic endothelial GM 7373 cells. Both molecules cause a similar increase in membrane-associated PKC activity and in the phosphorylation of a PKC-specific endogenous 87-kDa subs...

journal_title：Biochemical and biophysical research communications

authors： Maier JA,Presta M,Ragnotti G

更新日期：1989-04-28 00:00:00

abstract：:Adrenomedullin (ADM) is a vasodilator peptide, first isolated from human pheochromocytoma. To explore the pathophysiological role of ADM in ischemic conditions, we investigated the effects of hypoxia on ADM production and ADM mRNA expression in a cultured human colorectal carcinoma cell line, DLD-1. Northern blot anal...

journal_title：Biochemical and biophysical research communications

authors： Nakayama M,Takahashi K,Murakami O,Shirato K,Shibahara S

更新日期：1998-02-13 00:00:00

abstract：:We have established that differing effects of alpha1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both alpha1A- and alpha1B-ARs couple to Gs, while alpha1D-AR does not. To identify the region responsible for this difference in subtype-specific G...

journal_title：Biochemical and biophysical research communications

authors： Shinoura H,Shibata K,Hirasawa A,Tanoue A,Hashimoto K,Tsujimoto G

更新日期：2002-11-22 00:00:00

abstract：:Cancer cell molecular mimicry of stem cells (SC) follows with enhanced proliferative and renewal capacities. In support, numerous mediators of SC self-renewal have been evinced to exhibit oncogenic potential. More and more researches showed that the embryonic stem cell self-renewal genes express in various cancer cell...

journal_title：Biochemical and biophysical research communications

authors： Deng L,Xiang X,Yang F,Xiao D,Liu K,Chen Z,Zhang R,Feng G

更新日期：2017-08-19 00:00:00

abstract：:ATP-driven, rotenone-sensitive, reverse electron transfer from succinate to acetoacetate was measured in rat liver mitochondria in the presence of cyanide. In the approach to equilibrium, the absolute ratio of the free energy change of electron transfer to that of ATP hydrolysis exceeded 1, tending towards about 1 1/4...

journal_title：Biochemical and biophysical research communications

authors： Freedman JA,Lemasters JJ

更新日期：1984-11-30 00:00:00

abstract：:Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growt...

journal_title：Biochemical and biophysical research communications

authors： Qin B,Xiao B,Liang D,Xia J,Li Y,Yang H

更新日期：2011-06-24 00:00:00

abstract：:The carnitine/acylcarnitine carrier from rat liver mitochondria was overexpressed in Escherichia coli. The expressed protein, recovered as inclusion bodies, was solubilized with sarkosyl and purified by Sephadex G-200 and celite chromatography. A yield of 15 mg of purified transport protein per liter of cell culture w...

journal_title：Biochemical and biophysical research communications

authors： Indiveri C,Iacobazzi V,Giangregorio N,Palmieri F

更新日期：1998-08-28 00:00:00

abstract：:Using an anti-serum against synthetic alpha-inhibin-31, we have studied its cellular locations in rodent testis and brain. Western blot analysis detected several molecular forms of the protein(s). A protein of 17 KDa in size was detected in testis of one month old mice. Two major bands of molecular weights 39 kDA and ...

journal_title：Biochemical and biophysical research communications

authors： Lau YF,Li CH

更新日期：1987-05-29 00:00:00

abstract：:Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. We have found that elevations in cyclic AMP (cAMP) have long-term effects on both the beta-adrenergic receptor and adenylyl cyclase in cultured chick ventricular myocytes. Pretreatmen...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Green RD

更新日期：2003-07-18 00:00:00

abstract：:Galanin is a neuroendocrine peptide that modulates many different normal physiological effects including memory, weight, and pain perception. To better understand galanin receptor function, we cloned and characterized the galanin-1 receptor (GALN1R) gene isolated from a human P1 library. We determined that this gene c...

journal_title：Biochemical and biophysical research communications

authors： Lorimer DD,Matkowskj K,Benya RV

更新日期：1997-12-18 00:00:00