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Carbon monoxide exposure in rat heart: glutathione depletion is prevented by antioxidants.

Abstract：

:Rat hearts were perfused for 15min with buffer equilibrated with 0.01% or 0.05% CO. The buffer was equilibrated with 21% O(2) throughout. The ventricular glutathione content decreased by 76% and 84%, 90min post-exposure to 0.01% and 0.05% CO, respectively, compared with 0% CO controls (0.45+/-0.01 micromol/g wet tissue; +/-SEM, n=3). Both reduced and oxidised glutathione contributed to this decline. When ascorbate and Trolox C were included during exposure to 0.05% CO the glutathione pool was partly protected; here the glutathione decrease was 46%. In most hearts additional creatine kinase activity in the perfusate indicated minor tissue injury occurring immediately after the start and/or about 10min after the end of exposure to 0.01% CO or 0.05% CO. Ventricle lactate levels were unaffected by exposure to 0.01% CO. This evidence supports a role for oxidative stress in CO cardiotoxicity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Patel AP,John Moody A,Handy RD,Robert Sneyd J

doi

10.1016/s0006-291x(03)00190-6

subject

Has Abstract

pub_date

2003-03-07 00:00:00

pages

392-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X03001906

journal_volume

302

pub_type

杂志文章

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