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Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.

Abstract：

:MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino acid MutT module. The cloned mouse MTH2 (mMTH2) cDNA was expressed in Escherichia coli mutT(-) cells and the protein was purified. mMTH2 protein hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, with Km of 32 microM. Expression of cDNA for mMTH2 reduced significantly the elevated level of spontaneous mutation frequency of E. coli mutT(-) cells. Thus, MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals. MTH2 could act as an MTH1 redundancy factor.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

doi

10.1016/s0006-291x(03)00864-7

subject

Has Abstract

pub_date

2003-06-13 00:00:00

pages

1073-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X03008647

journal_volume

305

pub_type

杂志文章

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