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Hyperthermia and acidification stimulate mechano-growth factor synthesis in murine myoblasts and myotubes.

Abstract：

:The effect of cellular stress factors, the hyperthermia and the acidification of culture medium, on mechano-growth factor (MGF) synthesis by murine myoblasts in culture was investigated. Hyperthermia was shown to stimulate MGF expression both in primary myoblasts and in differentiated multinuclear myotubes. The induction of MGF synthesis peaked at 40 degrees capital ES, Cyrillic, with some activation at 39 and 41 degrees capital ES, Cyrillic. Decrease of culture medium pH stimulated MGF expression with a maximum at pH 6.3. Hydrocortisone eliminated induction of MGF synthesis completely both under hyperthermia and acidification conditions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kravchenko IV,Furalyov VA,Popov VO

doi

10.1016/j.bbrc.2008.08.016

subject

Has Abstract

pub_date

2008-10-17 00:00:00

pages

271-4

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01547-7

journal_volume

375

pub_type

杂志文章

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