当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Long noncoding RNA expression in dermal papilla cells contributes to hairy gene regulation.

Long noncoding RNA expression in dermal papilla cells contributes to hairy gene regulation.

Abstract：

:Dermal papilla (DP) cells may be the source of dermal-derived signaling molecules involved in hair-follicle development and postnatal hair cycling. Early-passage DP cells can induce hair growth in vivo, but, on further culture, this ability is lost. The cellular mechanisms underlying the hair-follicle induction property of early-passage DP cells are unclear. Long noncoding RNAs (lncRNAs) are an important class of genes involved in various biological functions. They are aberrantly expressed and play roles in the regulation of the Wnt signaling pathway, a critical point in maintaining hair-induction activity. LncRNA microarray revealed 1683 upregulated and 1773 downregulated lncRNAs in passage-4 DP cells compare with passage-10 DP cells. To investigate the relation between lncRNAs and coding genes in WNT signaling, we constructed a coding-noncoding gene co-expression network using lncRNAs and coding genes that were differentially expressed between the passage-4 and -10 DP cells. RP11-766N7.3, H19 and HOTAIR are specific lncRNAs that were aberrantly expressed in DP cells and played an important role in regulating Wnt signaling. This study may provide potential targets for discovering the hair-follicle induction mechanism of early-passage DP cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lin CM,Liu Y,Huang K,Chen XC,Cai BZ,Li HH,Yuan YP,Zhang H,Li Y

doi

10.1016/j.bbrc.2014.09.119

subject

Has Abstract

pub_date

2014-10-24 00:00:00

pages

508-14

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(14)01756-2

journal_volume

453

pub_type

杂志文章

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