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Identification of small molecule compounds active against Staphylococcus aureus and Proteus mirabilis.

Abstract：

:Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance. To help identify potential new drug candidates effective against the pathogen, a small focused library was screened for inhibition of bacterial growth against several pathogens, including S. aureus. At least one of the compounds, Compound 10, was capable of blocking bacterial growth of S. aureus in a test tube with IC50 = 140 ± 30 μM. Another inhibitor, Compound 7, was bacteriostatic against S. aureus with IC50 ranging from 33 to 150 μM against 3 different strains. However, only Compound 7 was bactericidal against P. mirabilis as examined by electron microscopy. Human cell line toxicity studies suggested that both compounds had small effect on cell growth at 100 μM concentration as examined by MTT assay. Analysis of compounds' structures showed lack of similarity to any known antibiotics and bacteriostatics, potentially offering the inhibitors as an alternative to existing solutions in controlling bacterial infections for selected pathogens.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Swietnicki W,Czarny A,Urbanska N,Drab M

doi

10.1016/j.bbrc.2018.10.189

subject

Has Abstract

pub_date

2018-12-02 00:00:00

pages

1047-1051

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)32377-5

journal_volume

506

pub_type

杂志文章

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