TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig.

abstract：:Erythropoietin has been thought to be secreted to plasma soon after the production because of the difficulty of Western blot analysis and immunohistochemistry. We established the new methods of Western blot analysis and immunohistochemistry. Using the new methods, we investigated the effects of aldosterone and fludroc...

journal_title：Biochemical and biophysical research communications

authors： Yasuoka Y,Izumi Y,Nagai T,Fukuyama T,Nakayama Y,Inoue H,Horikawa K,Kimura M,Nanami M,Yanagita K,Oshima T,Yamazaki T,Uematsu T,Yamamura R,Kobayashi N,Shimada Y,Nagaba Y,Nakanishi T,Yamashita T,Mukoyama M,Sato Y,K

更新日期：2018-09-18 00:00:00

abstract：:A key feature of O2 sensing by chemoreceptor tissues is the hypoxic inhibition of K+ channels. However, mechanisms coupling a fall of pO2 to channel closure differ between tissues: O2 regulation of K+ channels in chemoreceptive neuroepithelial bodies and their immortal counterparts, H146 cells, involves altered reacti...

journal_title：Biochemical and biophysical research communications

authors： O'Kelly I,Peers C,Kemp PJ

更新日期：2001-05-25 00:00:00

abstract：:Diacylglycerols inhibit binding of [20-3H]phorbol 12,13-dibutyrate ([3H]PDBu) to protein kinase C (the phorbol ester receptor). This inhibition could reflect competitive binding by the diglyceride. Alternatively, it might simply represent perturbation of the lipid environment required for binding activity. As predicte...

journal_title：Biochemical and biophysical research communications

authors： Sharkey NA,Blumberg PM

更新日期：1985-12-31 00:00:00

abstract：:We investigated the influence of the relative abundance of insulin and IGF-1 receptors on cellular growth, by measuring the stimulation of c-fos expression and of H3-thymidine incorporation into DNA by insulin and IGF-1 in CHO cells overexpressing insulin Receptor (CHO-IR). We found that CHO-IR cells were resistant to...

journal_title：Biochemical and biophysical research communications

authors： Maggi D,Laurino C,Andraghetti G,Cordera R

更新日期：1994-11-30 00:00:00

abstract：:We have previously reported that alpha-fetoprotein (AFP) inhibits infection of human monocyte-derived macrophages (MDM) by R5-HIV-1 strains and that a peptide mimicking the clade B HIV-1 gp120 consensus V3 domain (V3Cs) binds to CCR5. We demonstrate here that AFP binds high- and low-affinity binding sites of MDM, char...

journal_title：Biochemical and biophysical research communications

authors： Atemezem A,Mbemba E,Marfaing R,Vaysse J,Pontet M,Saffar L,Charnaux N,Gattegno L

更新日期：2002-08-23 00:00:00

abstract：:Most studies characterizing H-ras have been conducted in constitutively expressing cell lines. To explore the early interaction between H-ras p21 and signal transduction systems we have utilized an NIH3T3 fibroblast line transfected with a steroid inducible MMTV H-ras vector. Exposure to dexamethasone resulted in tran...

journal_title：Biochemical and biophysical research communications

authors： Murphy SK,Lindberg JB,Prussack DA

更新日期：1994-12-15 00:00:00

abstract：:Calpain was generally believed to exist and function only in the cytoplasm. However, m-calpain has now been detected in the extracellular spaces of some kinds of tissue. In this study, we demonstrated the existence of m-calpain in the medium surrounding MC3T3-E1 cultures, and its activity by zymography. At the same ti...

journal_title：Biochemical and biophysical research communications

authors： Nishihara H,Nakagawa Y,Ishikawa H,Ohba M,Shimizu K,Nakamura T

更新日期：2001-07-20 00:00:00

abstract：:In resting mesangial cells, angiotensin II and the calcium ionophore A23187 stimulated prostaglandin E2 (PGE2) formation. After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified res...

journal_title：Biochemical and biophysical research communications

authors： Pfeilschifter J,Mühl H

更新日期：1990-06-15 00:00:00

abstract：:HIV protease inhibitors (PIs) are often associated with metabolic and cardiovascular complications although they are effective anti-HIV drugs. In this study, we determined whether HIV PI ritonavir could increase endothelial permeability, one of the important mechanisms of vascular lesion formation. Human dermal microv...

journal_title：Biochemical and biophysical research communications

authors： Chen C,Lu XH,Yan S,Chai H,Yao Q

更新日期：2005-09-30 00:00:00

abstract：:Serotype conversion (O-antigen glucosylation) in Shigella flexneri is mediated by temperate bacteriophages, which encode a three-gene cluster that contains gtrA, gtrB, and gtr([type]). Sequence analysis has revealed that gtrA and gtrB are conserved and readily interchangeable between serotypes. The gtr([type]) is uniq...

journal_title：Biochemical and biophysical research communications

authors： Korres H,Mavris M,Morona R,Manning PA,Verma NK

更新日期：2005-03-25 00:00:00

abstract：:Mitochondria isolated from rats chronically fed ethanol were more sensitive to induction of the mitochondrial permeability transition (MPT) by a variety of agents than mitochondria isolated from isocalorically matched controls. The agents utilized have been implicated in both necrotic (Ca(2+)) and apoptotic (ceramide,...

journal_title：Biochemical and biophysical research communications

authors： Pastorino JG,Marcineviciute A,Cahill A,Hoek JB

更新日期：1999-11-19 00:00:00

abstract：:Many methods have been developed for chemical labeling and enhancement of the properties of antibodies and their common fragments, including the Fab and F(ab')2 fragments. Somewhat selective reduction of some antibody disulfide bonds has been previously achieved, yielding antibodies and antibody fragments that can be ...

journal_title：Biochemical and biophysical research communications

authors： Kirley TL,Greis KD,Norman AB

更新日期：2016-11-25 00:00:00

abstract：:Enzymatic properties of phosphorylated urokinase plasminogen activator (P-uPA) (1) extracted from human carcinomatous cell line Detroit 562 cells were compared with those of non-phosphorylated uPA of urinary origin (nP-uPA). Using plasminogen as a substrate, the Km and Kcat of P-uPA were higher than that of nP-uPA whi...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Kwaan HC,Koh E,Tanabe M

更新日期：1992-02-14 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK3beta) is recognized as one of major kinases to phosphorylate tau in Alzheimer's disease (AD), thus lots of AD drug discoveries target GSK3beta. However, the inactive form of GSK3beta which is phosphorylated at serine-9 is increased in AD brains. This is also inconsistent with phosph...

journal_title：Biochemical and biophysical research communications

authors： Lim YW,Yoon SY,Choi JE,Kim SM,Lee HS,Choe H,Lee SC,Kim DH

更新日期：2010-04-30 00:00:00

abstract：:Guanine nucleotide-binding protein (G protein) coupled receptors (GPCRs) are frequently expressed by a baculovirus expression vector system (BEVS). We recently established a novel BEVS using the bacmid system of Bombyx mori nucleopolyhedrovirus (BmNPV), which is directly applicable for protein expression in silkworms....

journal_title：Biochemical and biophysical research communications

authors： Kajikawa M,Sasaki K,Wakimoto Y,Toyooka M,Motohashi T,Shimojima T,Takeda S,Park EY,Maenaka K

更新日期：2009-07-31 00:00:00

abstract：:Glycosyl-phosphatidylinositol (GPI) anchored proteins are surveyed in two insulin sensitive cell types by surface labeling and phospholipase C-induced release into the medium. Serum starvation selectively increases both the number and intensity of a subset of GPI-anchored proteins. After serum starvation, loss of cell...

journal_title：Biochemical and biophysical research communications

authors： Lisanti MP,Darnell JC,Chan BL,Rodriguez-Boulan E,Saltiel AR

更新日期：1989-10-31 00:00:00

abstract：:Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolate...

journal_title：Biochemical and biophysical research communications

authors： Schweitzer K,Decker E,Zhu L,Miller RE,Mirra SS,Spina S,Ghetti B,Wang M,Murrell J

更新日期：2006-09-22 00:00:00

abstract：:The characteristics of carcinoembryonic antigen (CEA) molecules expressed by different cell types have been examined using cDNA transfection into cells of epithelial, neuroectodermal and hematopoietic origin. Variability in the CEA molecules was observed in terms of monoclonal antibody binding, apparent molecular weig...

journal_title：Biochemical and biophysical research communications

authors： Grimm T,Riethmüller G,Johnson JP

更新日期：1994-11-15 00:00:00

abstract：:Regarding the molecular mechanism of dynamin in receptor-mediated endocytosis, GTPase activity of dynamin has been thought to have a critical role in endocytic vesicle internalization. However, a recent report suggested that GTP-binding to dynamin itself activates the dynamin to recruit molecular machinery necessary f...

journal_title：Biochemical and biophysical research communications

authors： Jeong MJ,Yoo J,Lee SS,Lee KI,Cho A,Kwon BM,Moon MJ,Park YM,Han MY

更新日期：2001-04-27 00:00:00

abstract：:The brown planthopper, Nilaparvata lugens (N. lugens, Hemiptera: Delphacidae), and the green rice leafhopper, Nephotettix cincticeps (N. cincticeps, Hemiptera: Cicadellidae), two sap-sucking feeders, have caused many destructive agricultural disasters in East Asia, as they can bring diseases like 'hopper burn' and tra...

journal_title：Biochemical and biophysical research communications

authors： Qian N,Zheng P,Wang Y,Pan S,Li Y,Zhang C,Chen J,Teng J

更新日期：2016-02-19 00:00:00

abstract：:We report here the clinical, genetic, and molecular characterization of three Chinese families with maternally transmitted Leber's hereditary optic neuropathy (LHON). Clinical and genetic evaluations revealed the variable severity and age-of-onset in visual impairment in these families. In the affected matrilineal rel...

journal_title：Biochemical and biophysical research communications

authors： Sun YH,Wei QP,Zhou X,Qian Y,Zhou J,Lu F,Qu J,Guan MX

更新日期：2006-08-18 00:00:00

abstract：:A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 ...

journal_title：Biochemical and biophysical research communications

authors： Ishizaka Y,Ishizaka Y,Tanaka M,Kitamura K,Kangawa K,Minamino N,Matsuo H,Eto T

更新日期：1994-04-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have both protective and pathological roles in inflammation, and transcriptional mechanisms are important in regulating physiological levels to maintain health. Zinc-binding protein-89 (ZBP-89) is a transcription factor with roles in regulating vital cellular processes, acting through ...

journal_title：Biochemical and biophysical research communications

authors： Borghaei RC,Gorski G,Seutter S,Chun J,Khaselov N,Scianni S

更新日期：2016-03-18 00:00:00

abstract：:The morphology and function of Leydig cells are changed during the development, mature and senility of Leydig cells along the life span of males. This study was to observe the growth morphology of adult mouse Leydig cells in culture, aiming to provide a reference for furthermore understanding of the biological functio...

journal_title：Biochemical and biophysical research communications

authors： Wang JQ,Cao WG

更新日期：2016-01-22 00:00:00

abstract：:We have cloned and sequenced a full-length cDNA (1083 bp) encoding the human liver cystathionine-gamma-lyase enzyme (cystathionase). The human cystathionase sequence presented a substantial deletion of 132 bases (44 amino acids) compared to that reported for rat cystathionase, and of 135 bases (45 amino acids) compare...

journal_title：Biochemical and biophysical research communications

authors： Lu Y,O'Dowd BF,Orrego H,Israel Y

更新日期：1992-12-15 00:00:00

abstract：BACKGROUND:During implantation, the blastocyst trophectoderm attaches to the endometrial epithelium and continues to differentiate into all trophoblast subtypes, which are the major components of a placenta. Aberrant trophoblast proliferation and differentiation are associated with placental diseases. However, due to e...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Wang K,Chandramouli GV,Knott JG,Leach R

更新日期：2013-07-12 00:00:00

abstract：:Depending on culture in either "low Ca++" (0.25 mM) or "normal Ca++" (1.8 mM) medium, human colon adenocarcinoma-derived CaCo-2 cells exhibit differential sensitivity to the antiproliferative action of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and of two side-chain modified analogs, 1,25S,26-trihydroxy-delta 22-vitamin D...

journal_title：Biochemical and biophysical research communications

authors： Cross HS,Huber C,Peterlik M

更新日期：1991-08-30 00:00:00

abstract：:ERK8 is the most recent addition for the MAPK family, and its mechanism of activation and function are not yet known, mainly due to the lack of any known physiological stimulator. In this report, we describe the preparation of reagents for the use of a novel method, the ligand interaction scan (LIScan), to study the f...

journal_title：Biochemical and biophysical research communications

authors： Erster O,Seger R,Liscovitch M

更新日期：2010-08-13 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subu...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yang Q,Wu X,Yang Y,Shi L,Wang C,Wu G,Xia Y,Yang B,Zhang R,Xu C,Cheng X,Li S,Zhao Y,Fu F,Liao Y,Fang F,Chen Q,Tu X,Wang QK

更新日期：2010-07-16 00:00:00

abstract：:Variations in the UDP-glucuronosyltransferase (UGT) 1A7 gene have been found to be related to the development of hepatocellular carcinoma (HCC). Since the pathogenesis of liver cirrhosis is not dissimilar to that of HCC, we hypothesized that UGT1A7 genetic polymorphisms may be associated with liver cirrhosis. PCR-rest...

journal_title：Biochemical and biophysical research communications

authors： Tang KS,Lee CM,Teng HC,Huang MJ,Huang CS

更新日期：2008-02-15 00:00:00