Aberrantly regulated proteins in frontotemporal dementia.

Abstract:

:Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.

authors

Schweitzer K,Decker E,Zhu L,Miller RE,Mirra SS,Spina S,Ghetti B,Wang M,Murrell J

doi

10.1016/j.bbrc.2006.07.113

subject

Has Abstract

pub_date

2006-09-22 00:00:00

pages

465-72

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)01623-8

journal_volume

348

pub_type

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