当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Trophoblast lineage cells derived from human induced pluripotent stem cells.

Trophoblast lineage cells derived from human induced pluripotent stem cells.

Abstract：

BACKGROUND:During implantation, the blastocyst trophectoderm attaches to the endometrial epithelium and continues to differentiate into all trophoblast subtypes, which are the major components of a placenta. Aberrant trophoblast proliferation and differentiation are associated with placental diseases. However, due to ethical and practical issues, there is almost no available cell or tissue source to study the molecular mechanism of human trophoblast differentiation, which further becomes a barrier to the study of the pathogenesis of trophoblast-associated diseases of pregnancy. In this study, our goal was to generate a proof-of-concept model for deriving trophoblast lineage cells from induced pluripotency stem (iPS) cells from human fibroblasts. In future studies the generation of trophoblast lineage cells from iPS cells established from patient's placenta will be extremely useful for studying the pathogenesis of individual trophoblast-associated diseases and for drug testing. METHODS AND RESULTS:Combining iPS cell technology with BMP4 induction, we derived trophoblast lineage cells from human iPS cells. The gene expression profile of these trophoblast lineage cells was distinct from fibroblasts and iPS cells. These cells expressed markers of human trophoblasts. Furthermore, when these cells were differentiated they exhibited invasive capacity and placental hormone secretive capacity, suggesting extravillous trophoblasts and syncytiotrophoblasts. CONCLUSION:Trophoblast lineage cells can be successfully derived from human iPS cells, which provide a proof-of-concept tool to recapitulate pathogenesis of patient placental trophoblasts in vitro.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen Y,Wang K,Chandramouli GV,Knott JG,Leach R

doi

10.1016/j.bbrc.2013.06.016

subject

Has Abstract

pub_date

2013-07-12 00:00:00

pages

677-84

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00990-X

journal_volume

436

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Crystal structure and biophysical characterisation of Helicobacter pylori phosphopantetheine adenylyltransferase.

    abstract：:Helicobacter pylori is a bacterium that causes chronic active gastritis and peptic ulcers. Drugs targeting H. pylori phosphopantetheine adenylyltransferase (HpPPAT), which is involved in CoA biosynthesis, may be useful. Herein, we report the expression in Escherichia coli and purification of recombinant HpPPAT and des...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.058

    authors： Cheng CS,Chen CH,Luo YC,Chen WT,Chang SY,Lyu PC,Kao MC,Yin HS

    更新日期：2011-05-06 00:00:00

  • Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics.

    abstract：:The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin. The material was reduced and alkylated and the A- and the B-chain were separated by reversed phase chromatography and subjected to Edman degradation and amino acid analysis. It was shown that the A-chain c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90369-x

    authors： Hellman U,Wernstedt C,Westermark P,O'Brien TD,Rathbun WB,Johnson KH

    更新日期：1990-06-15 00:00:00

  • Cross-reactivity between human cytomegalovirus peptide 981-1003 and myelin oligodendroglia glycoprotein peptide 35-55 in experimental autoimmune encephalomyelitis in Lewis rats.

    abstract：:Multiple sclerosis (MS) has been documented to have various clinical and pathological presentations. However the underlying mechanisms remain unknown. Viral infections may play a certain role in the etiopathogenesis of MS. This study was designed to explore whether different phospholipid peptides and viral mimic pepti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.12.122

    authors： Zheng MM,Zhang XH

    更新日期：2014-01-17 00:00:00

  • Differential expression of mammalian TRP homologues across tissues and cell lines.

    abstract：:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7458

    authors： Garcia RL,Schilling WP

    更新日期：1997-10-09 00:00:00

  • Identification of small molecule compounds active against Staphylococcus aureus and Proteus mirabilis.

    abstract：:Staphylococcus aureus is a human pathogen rapidly becoming a serious health problem due to ease of acquiring antibiotic resistance. To help identify potential new drug candidates effective against the pathogen, a small focused library was screened for inhibition of bacterial growth against several pathogens, including...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.189

    authors： Swietnicki W,Czarny A,Urbanska N,Drab M

    更新日期：2018-12-02 00:00:00

  • Molecular phylogeny of C1 inhibitor depicts two immunoglobulin-like domains fusion in fishes and ray-finned fishes specific intron insertion after separation from zebrafish.

    abstract：:C1 inhibitor (C1IN) is a multi-facet serine protease inhibitor in the plasma cascades, inhibiting several proteases, notably, regulates both complement and contact system activation. Despite huge advancements in the understanding of C1IN based on biochemical properties and its roles in the plasma cascades, the phyloge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.05.097

    authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

    更新日期：2014-07-18 00:00:00

  • Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11.

    abstract：:Flo8 is a transcriptional activator essential for the inducible expression of a set of target genes such as STA1, FLO11, and FLO1 encoding an extracellular glucoamylase and two cell surface proteins, respectively. However, the molecular mechanism of Flo8-mediated transcriptional activation remains largely elusive. By ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.161

    authors： Kim HY,Lee SB,Kang HS,Oh GT,Kim T

    更新日期：2014-06-27 00:00:00

  • Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization.

    abstract：:Cultured endothelial cells release a potent vasoconstrictor peptide, endothelin. Cumulative addition of synthetic endothelin to isolated rabbit aortic rings elicited a concentration-dependent increase in contractile tension which was endothelium-independent. In cultured rabbit vascular smooth muscle cells loaded with ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80180-9

    authors： Marsden PA,Danthuluri NR,Brenner BM,Ballermann BJ,Brock TA

    更新日期：1989-01-16 00:00:00

  • Long-chained 1-mercapto-n-alkanes as potent inhibitors toward liver alcohol dehydrogenase.

    abstract：:Long-chained 1-mercapto-n-alkanes showed potent inhibitory effects on horse liver alcohol dehydrogenase (HLADH). The inhibitory effect of the thiols was enhanced by increasing the number of the alkyl carbon atoms up to 10-12 and steeply lowered by further increase in the carbon number. The HLADH activity was almost co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91512-9

    authors： Miwa K,Okuda H,Ogura K,Watabe T

    更新日期：1987-02-13 00:00:00

  • The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2.

    abstract：:Involucrin is an important marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia. Several transcription factors and regulatory elements had been described as responsible for turning on the gene. However, it is evident th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.034

    authors： Azuara-Liceaga E,Sandoval M,Corona M,Gariglio P,López-Bayghen E

    更新日期：2004-05-28 00:00:00

  • Quantitative analysis of the transcription factor AP2 binding to DNA by atomic force microscopy.

    abstract：:Atomic force microscopy (AFM) allows to study the molecular structure of biological macromolecules with nm to A resolutions without crystallization. We show here the applicability of AFM in the quantitative analysis of the molecular mechanisms of DNA/protein interaction: (i) Protein-binding sites can be mapped over a ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1409

    authors： Nettikadan S,Tokumasu F,Takeyasu K

    更新日期：1996-09-24 00:00:00

  • Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.

    abstract：:Lung cancer is the leading cause of cancer death worldwide. PARP inhibitors have become a new line of cancer therapy and a successful demonstration of the synthetic lethality concept. The mechanism and efficacy of PARP inhibitors have been well studied in some cancers, especially homologous recombination (HR)-deficien...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.11.050

    authors： Ji W,Weng X,Xu D,Cai S,Lou H,Ding L

    更新日期：2020-01-29 00:00:00

  • Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment.

    abstract：:Impaired activity of NK (natural killer) cells has been proposed as a mechanism contributing to viral persistence and chronic infection in hepatitis C (HCV) infection. We aimed to assess the impact of HCV infection on NK cells regarding frequency, subset distribution, and cytotoxic and cytokine secretion functions, as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.008

    authors： Dessouki O,Kamiya Y,Nagahama H,Tanaka M,Suzu S,Sasaki Y,Okada S

    更新日期：2010-03-05 00:00:00

  • cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3.

    abstract：:The cDNA encoding the UDP glucuronosyltransferase, UGT1A3, has been cloned and expressed in cell culture. The deduced amino acid sequence of the cDNA is 90% similar in sequence to that of a previously characterized form, UGT1A4 and to that of a third form, UGT1A5 whose function in unknown. UGT1A3, when expressed in CO...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1251

    authors： Mojarrabi B,Butler R,Mackenzie PI

    更新日期：1996-08-23 00:00:00

  • Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.

    abstract：:Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β (Aβ), the aggregation of which is known to cause Alzheimer's disease. Therefore, C99 remo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.060

    authors： Jang JK,Park KJ,Lee JH,Ko KY,Kang S,Kim IY

    更新日期：2017-04-29 00:00:00

  • High production of type VI collagen in multiple fibromatosis with multiple articular dysplasia.

    abstract：:A patient with multiple fibromatosis occurring at the sites of multiple cartilagenous dysplasia was described. Collagen types solubilized with pepsin from the fibromatous tissue were fractionated by a different salt concentration and analyzed by SDS-polyacrylamide gel electrophoresis, which indicated that the tissue p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80117-1

    authors： Murata K,Motoyama T,Suka M,Ohno M,Kuboki Y

    更新日期：1987-08-31 00:00:00

  • Rapid grouping of HIV-1 infection in subtypes A to E by V3 peptide serotyping and its relation to sequence analysis.

    abstract：:We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to E). In eight patients serologically subtyped as A (n = 1), B (n = 3), C (n = 3) and E (n = 1) phyllogenetic analysis of sequenced V3 domain DNA completely correlated to the peptide serotyping. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2858

    authors： Sherefa K,Sönnerborg A,Steinbergs J,Sällberg M

    更新日期：1994-12-30 00:00:00

  • Alpha Mangostin promotes myogenic differentiation of C2C12 mouse myoblast cells.

    abstract：:Mangosteen, a fruit mainly produced in Southeast Asia, has been used as food and as an antipyretic and for treating skin diseases. The xanthones contained in mangosteen have many physiological activities including melanin suppression and anticancer activities, but little is known about the physiological effects of the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.04.128

    authors： Lin M,Zhou S,Sakamoto K

    更新日期：2020-07-12 00:00:00

  • Precise characterization of GlnR Box in actinomycetes.

    abstract：:GlnR has been characterized as a central regulator governing most nitrogen metabolisms in many important actinomycetes. So far, the GlnR binding consensus sequences have been extensively studied, but with different motifs proposed, which has therefore brought confusion and impeded the understanding of the in-depth mol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.010

    authors： Wang J,Wang Y,Zhao GP

    更新日期：2015-03-13 00:00:00

  • Engineering of heterologous cytochrome P450 in Acinetobacter sp.: application for pollutant degradation.

    abstract：:Many organisms do not contain the necessary biochemical armoury to carry out the initial oxidative attack of many pollutant chemicals. In the present study, Acinetobacter sp. strain BD413 has been genetically engineered to express the cytochrome P450 xenobiotic-metabolising enzyme CYP105D1 from Streptomyces griseus th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3541

    authors： Lamb DC,Kelly DE,Masaphy S,Jones GL,Kelly SL

    更新日期：2000-09-24 00:00:00

  • Conserved and hybrid meta-cleavage operons from PAH-degrading Burkholderia RP007.

    abstract：:We have compared the sequence and gene order of meta-cleavage pathway operons from alpha- and gamma-subgroups of the Proteobacteria with operons from Burkholderia sp. strain RP007 which belongs to the beta-subgroup of the Proteobacteria. Burkholderia RP007 was isolated for its ability to degrade phenanthrene and conta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1153

    authors： Laurie AD,Lloyd-Jones G

    更新日期：1999-08-19 00:00:00

  • Expression analysis for inverted effects of serotonin transporter inactivation.

    abstract：:Inactivation of serotonin transporter (HTT) by pharmacologically in the neonate or genetically increases risk for depression in adulthood, whereas pharmacological inhibition of HTT ameliorates symptoms in depressed patients. The differing role of HTT function during early development and in adult brain plasticity in c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.01.041

    authors： Ichikawa M,Okamura-Oho Y,Shimokawa K,Kondo S,Nakamura S,Yokota H,Himeno R,Lesch KP,Hayashizaki Y

    更新日期：2008-03-28 00:00:00

  • Protein tyrosine phosphorylation triggered by human Fc gamma RII.

    abstract：:The role of the cytoplasmic domain of human Fc gamma RII in cellular activation was studied by transfecting P815 cells with different isoforms or deletion mutants of this receptor and then assaying protein tyrosine phosphorylation after crosslinking with anti-CD32 monoclonal antibodies. Fc gamma RIIa, but not Fc gamma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1775

    authors： Liu Z,Pudiak D,Looney RJ

    更新日期：1994-06-15 00:00:00

  • Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis.

    abstract：:We cloned a cDNA encoding a novel extracellular signal-regulated kinase (ERK) 2-binding protein, EBITEIN1, by yeast two-hybrid screening. Northern and Western blotting experiments showed that the transcript and protein were expressed in the testes. Furthermore, immunohistochemical experiments showed that EBITEIN1 exis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.01.078

    authors： Miura K,Imaki J

    更新日期：2008-04-04 00:00:00

  • Isolation and characterization of iso-rANP, a new natriuretic peptide from rat atria.

    abstract：:Using a specific radioimmunoassay we have isolated and sequenced a new 45-amino acid peptide from rat atria which exhibits similar physiological and pharmacological properties to rat atrial natriuretic peptide (rANP). We have termed the new peptide iso-rANP, because of its functional and structural similarities to rAN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92675-2

    authors： Flynn TG,Brar A,Tremblay L,Sarda I,Lyons C,Jennings DB

    更新日期：1989-06-15 00:00:00

  • DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26.

    abstract：:A type II DNA topoisomerase has been partially purified from calf thymus mitochondria by a combination of differential centrifugation and column chromatography. The mitochondrial enzyme was inhibited by amsacrine (m-AMSA) slightly at 0.5 microM, significantly at 5.0 microM, and completely at 50 microM. A similar profi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80239-6

    authors： Lin JH,Castora FJ

    更新日期：1991-04-30 00:00:00

  • Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells.

    abstract：:Numerous epidemiological data indicate that vitamin D receptor (VDR) signaling induced by its ligand or active metabolite 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) has anti-cancer activity in several colon cancers. 1α,25(OH)(2)D(3) induces the epithelial differentiation of SW480 colon cancer cells expressing VDR ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.045

    authors： Kouchi Z,Fujiwara Y,Yamaguchi H,Nakamura Y,Fukami K

    更新日期：2011-05-20 00:00:00

  • NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma.

    abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.05.037

    authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

    更新日期：2017-06-17 00:00:00

  • Advanced glomerulosclerosis is reversible in nephrotic mice.

    abstract：:Advanced glomerulosclerosis, a common hallmark of chronic renal diseases (CRD) is believed to be irreversible, and it is thought that glomerular hyperfiltration and hypertrophy may participate in its pathogenesis. We demonstrate here that glomerulosclerosis is "reversible" in an animal model. We used nephrotic ICGN (n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4903

    authors： Mizuno-Horikawa Y,Mizuno S,Tamura S,Kurosawa T

    更新日期：2001-06-15 00:00:00

  • Corticotropin-releasing factor differentially regulates proopiomelanocortin messenger ribonucleic acid levels in anterior as compared to intermediate pituitary lobes of rats.

    abstract：:Chronic subcutaneous infusion of small doses (0.1 microgram/h) of ovine corticotropin-releasing factor (oCRF) into rats for 8 days resulted in differential alteration of proopiomelanocortin (POMC) mRNA levels in the individual pituitary lobes: In the anterior lobe POMC mRNA levels, quantitated by hybridisation using a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91568-7

    authors： Höllt V,Haarmann I

    更新日期：1984-10-30 00:00:00