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Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells.

Abstract：

:A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 x 10(-9) M). In a receptor binding assay for AM in rat VSMC, the binding of [125I] AM was competitively inhibited by human AM, but not by human CGRP. Thus, AM is thought to increase intracellular cAMP in rat VSMC via its specific receptor to evoke vasodilation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishizaka Y,Ishizaka Y,Tanaka M,Kitamura K,Kangawa K,Minamino N,Matsuo H,Eto T

doi

10.1006/bbrc.1994.1496

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

642-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71496-3

journal_volume

200

pub_type

杂志文章

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