Noncytopathic strains of bovine viral diarrhea virus prime bovine bone marrow-derived macrophages for enhanced generation of nitric oxide.

abstract：:Lafora disease, a progressive myoclonus epilepsy, is an autosomal recessive disease caused in approximately 80% of cases by mutation of the EPM2A gene, which encodes a dual specificity protein phosphatase called laforin. In addition to its phosphatase domain, laforin contains an N-terminal carbohydrate-binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Roach PJ

更新日期：2004-12-17 00:00:00

abstract：:Angiotensin II (Ang II) and oxidized LDL (Ox-LDL) are risk factors for atherosclerosis, and both of them contribute to macrophage cholesterol accumulation, the hallmark of early atherosclerosis. As Ang II was shown to increase macrophage uptake of Ox-LDL, we investigated the effect of losartan, an Ang II receptor anta...

journal_title：Biochemical and biophysical research communications

authors： Hayek T,Aviram M,Heinrich R,Sakhnini E,Keidar S

更新日期：2000-07-05 00:00:00

abstract：:Although proteins are generally composed of l-alpha-amino acids, biologically uncommon D-beta-aspartic acid (Asp)-containing proteins have been reported in various tissues from elderly individuals. Our previous study indicated that the N/N1003A cell line, derived from rabbit lens, includes D-beta-Asp-containing protei...

journal_title：Biochemical and biophysical research communications

authors： Takata T,Shimo-Oka T,Miki K,Fujii N

更新日期：2005-09-09 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies, column chromatography on QAE-Sephadex and SDS-polyacrylamide gel electrophoresis. Two different isozymes, M-type and L-type, were found. The M(r) values of the M and L ...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1995-11-22 00:00:00

abstract：:Meiotic cells of Coprinus contain a protein that can be identified by its ability to enhance activity of the meiotic DNA polymerase reported previously (8). Its activity is found only during the prophase stages in meiotic cells, and is accompanied by the meiotic polymerase. The protein, which was purified to near homo...

journal_title：Biochemical and biophysical research communications

authors： Gomi K,Sakaguchi K

更新日期：1994-02-15 00:00:00

abstract：:ATP-binding cassette sub-family G member 2 (ABCG2) confers to the major phenotypes of side population (SP) cells, the cancer stem-like cells. In this study, the SP cells displayed a distinctly higher ABCG2 expression level, sphere formation efficiency (SFE) and growth rate even under hypoxia condition. CXCR4 overexpre...

journal_title：Biochemical and biophysical research communications

authors： He C,Zhang H,Wang B,He J,Ge G

更新日期：2018-10-28 00:00:00

abstract：:Leydig cells were purified from rat testes by discontinuous metrizamide density gradient and were shown to contain renin (EC 3.4.99.1), angiotensin-converting enzyme (dipeptidyl carboxypeptidase, (EC 3.4.15.1), and the peptide hormone angiotensins I, II and III as determined by the combined HPLC and radioimmunoassay. ...

journal_title：Biochemical and biophysical research communications

authors： Pandey KN,Misono KS,Inagami T

更新日期：1984-08-16 00:00:00

abstract：:A single residue that dramatically influences polymerization of principal cell division protein FtsZ of Mycobacterium leprae (MlFtsZ) and Mycobacterium tuberculosis (MtFtsZ) has been identified. Soluble, recombinant MlFtsZ did not show polymerization in vitro, in contrast to MtFtsZ, which polymerised. Mutation of the ...

journal_title：Biochemical and biophysical research communications

authors： Gupta P,Srinivasan R,Rajeswari H,Indi S,Ajitkumar P

更新日期：2008-04-04 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:We characterized the function of mouse organic cation transporter OCT2 (TC 2.A.19.1.5) in comparison with that of OCT1 (TC 2.A.19.1.1). Uptake of [(3)H]1-methyl-4-phenylpyridinium ([(3)H]MPP(+)) by Xenopus laevis oocytes injected with mOCT1 (Slc22a1) or mOCT2 (Slc22a2) cRNA was attenuated by an increase of extracellul...

journal_title：Biochemical and biophysical research communications

authors： Kakehi M,Koyabu N,Nakamura T,Uchiumi T,Kuwano M,Ohtani H,Sawada Y

更新日期：2002-08-23 00:00:00

abstract：:Because the expression of EBNA1 is prevalent in all EBV-associated tumors, it has become one of the most attractive drug targets for the discovery of anti-EBV compounds. In a cell-based reporter system, EBNA1 consistently upregulated the transcription of an oriP-Luc mini-EBV episome by 6- to 8-fold. The treatment of c...

journal_title：Biochemical and biophysical research communications

authors： Chen YL,Tsai HL,Peng CW

更新日期：2012-01-20 00:00:00

abstract：:Kinetics of permeation through connexin 43-EGFP hemichannels (Cx43-EGFP HCs) were evaluated in divalent cation-free solutions, which enhance HC open probability and thus, allow measurements during initial velocity. Three cations that become fluorescent upon binding to intracellular nucleic acids [ethidium (Etd), propi...

journal_title：Biochemical and biophysical research communications

authors： Orellana JA,Díaz E,Schalper KA,Vargas AA,Bennett MV,Sáez JC

更新日期：2011-06-17 00:00:00

abstract：:Circadian variations in the levels of prostaglandins (PGs) D2, E2, and F2 alpha were studied in the cerebrospinal fluid (CSF) of rats. We collected CSF samples from the cisterna magna of anesthetized rats at different clock-hours (1000, 1400, 1800, 2200, 0200, and 0600 hr), and measured the concentrations of the three...

journal_title：Biochemical and biophysical research communications

authors： Pandey HP,Ram A,Matsumura H,Satoh S,Hayaishi O

更新日期：1995-08-15 00:00:00

abstract：:The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

journal_title：Biochemical and biophysical research communications

authors： Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

更新日期：2011-08-12 00:00:00

abstract：:The adsorption of D-fructose within the lumen of the human small intestine is thought to be mediated by the GLUT5 isoform of the human facilitative sugar transporter family. This isoform has been expressed in oocytes and shown to be capable of D-fructose transport. Some debate remains regarding the absolute substrate ...

journal_title：Biochemical and biophysical research communications

authors： Kane S,Seatter MJ,Gould GW

更新日期：1997-09-18 00:00:00

abstract：:Cloned murine mammary tumor virus (MuMTV) sequences allowed us to search for murine mammary tumor virus related sequences in the DNA of surgically removed human breast tumors. Out of 28 tumors so far examined two were found to contain an Eco RI DNA fragment homologous to the long terminal repeat-group antigen (LTR-Gag...

journal_title：Biochemical and biophysical research communications

authors： Crépin M,Lidereau R,Chermann JC,Pouillart P,Magdamenat H,Montagnier L

更新日期：1984-01-13 00:00:00

abstract：:Cellobiose triggers the production of two endoglucanases, EglA and EglB, in Aspergillus nidulans. The cellulose responsive element (CeRE) cis-element that is essential for induction has been identified on the eglA promoter, but transcription factors that bind to CeRE have not yet been identified. CeRE contained a cons...

journal_title：Biochemical and biophysical research communications

authors： Yamakawa Y,Endo Y,Li N,Yoshizawa M,Aoyama M,Watanabe A,Kanamaru K,Kato M,Kobayashi T

更新日期：2013-02-22 00:00:00

abstract：:Immunoglobulin A (IgA) nephropathy is an important cause of end-stage kidney disease (ESKD). Tubulointerstitial inflammation and subsequent fibrosis appear to be a major contributor of the disease progression to ESKD; however, the underlying mechanism is poorly understood. Herein, we report that a unique feature of CY...

journal_title：Biochemical and biophysical research communications

authors： Cui TG,Ichikawa T,Yang M,Dong X,Li J,Cui T

更新日期：2009-12-11 00:00:00

abstract：:The yeast Saccharomyces cerevisiae mRNA capping enzyme is composed of two subunits of alpha (52 kDa, mRNA guanylyltransferase) and beta (80 kDa, RNA 5'-triphosphatase). We have isolated the alpha subunit gene (CEG1) by immunological screening. In this report, with the aid of partial amino acid sequences of purified ye...

journal_title：Biochemical and biophysical research communications

authors： Tsukamoto T,Shibagaki Y,Imajoh-Ohmi S,Murakoshi T,Suzuki M,Nakamura A,Gotoh H,Mizumoto K

更新日期：1997-10-09 00:00:00

abstract：:A novel procedure is described for the assignment of the position of O-acylated residues in the sequence of oligosaccharides. The procedure is both rapid and sensitive and complements existing carbohydrate techniques. The procedure involves the use of derivatisation, using conditions under which naturally occurring O-...

journal_title：Biochemical and biophysical research communications

authors： Dell A,Tiller PR

更新日期：1986-03-28 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance, dyslipidemia and a systemic pro-inflammatory response, a leading cause of cirrhosis and hepatocellular carcinoma. Here, we showed that PDZ-LIM domain-containing protein 2 (PDLIM2) was an effective suppressor of steatoh...

journal_title：Biochemical and biophysical research communications

authors： Hao YR,Tang FJ,Zhang X,Wang H

更新日期：2018-09-05 00:00:00

abstract：:Antileukoprotease (ALP) was isolated from bronchial secretion. The amino acid composition as well as the N-terminal sequence were determined. No homology with other low molecular weight proteinase inhibitors was found. ...

journal_title：Biochemical and biophysical research communications

authors： Klasen EC,Kramps JA

更新日期：1985-04-16 00:00:00

abstract：:Extracellular matrix facilitates anchorage-dependent cell survival via interaction of its arginine-glycine-aspartate (RGD) motif with integrins. In this report, we describe an unexpected, apoptosis-promoting the effect of immobilized RGD (iRGD) on tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. Mesangial ce...

journal_title：Biochemical and biophysical research communications

authors： Moreno-Manzano V,Lucio-Cazana J,Konta T,Nakayama K,Kitamura M

更新日期：2000-10-22 00:00:00

abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

journal_title：Biochemical and biophysical research communications

authors： Puri RK,Leland P

更新日期：1993-12-30 00:00:00

abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Shelat H,Geng YJ

更新日期：2012-10-05 00:00:00

abstract：:N-acetylglucosaminyltransferase I (GlcNAc-TI) catalyzes the first reaction in the conversion of ASN-linked cell surface oligosaccharides from a mannose-terminating structure to more complex carbohydrate structures. The mutant Chinese hamster ovary (CHO) cell line, Lec1, is deficient in this enzyme and, therefore, show...

journal_title：Biochemical and biophysical research communications

authors： Ripka J,Pierce M,Fregien N

更新日期：1989-03-15 00:00:00

abstract：:Vitamin C, or ascorbic acid, decreases paracellular endothelial permeability in a process that requires rearrangement of the actin cytoskeleton. To define the proximal mechanism of this effect, we tested whether it might involve enhanced generation and/or sparing of nitric oxide (NO) by the vitamin. EA.hy926 endotheli...

journal_title：Biochemical and biophysical research communications

authors： May JM,Qu ZC

更新日期：2011-01-14 00:00:00

abstract：:We recently reported that the ETV6/FLT3 fusion protein conferred interleukin-3-independent growth on Ba/F3 cells. The present study has been conducted to assess role of the juxtamembrane domain of FLT3 for signal transduction and cell transformation. The wild-type ETV6/FLT3 fusion protein in transfected cells was a co...

journal_title：Biochemical and biophysical research communications

authors： Vu HA,Xinh PT,Kano Y,Tokunaga K,Sato Y

更新日期：2009-06-05 00:00:00

abstract：:Infection of influenza virus could induce acute lung inflammatory injury (ALII) that was at least partially caused by excessive innate immune responses. To study whether down-regulating Toll-like receptor (TLR)-mediated innate immune response could lessen influenza virus-induced ALII, a microsatellite DNA mimicking ol...

journal_title：Biochemical and biophysical research communications

authors： Fang M,Wan M,Guo S,Sun R,Yang M,Zhao T,Yan Y,Zhang Y,Huang W,Wu X,Yu Y,Wang L,Hua S

更新日期：2011-11-18 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00