The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation.

abstract：:Angiogenesis plays a vital role in tumor progression and metastasis. To better understand the role of anesthesia in tumor biology, we previously reported that bupivacaine displayed the inhibitory effects in endothelial cells. In this work, we demonstrated that fentanyl, an opioid medication commonly used in cancer pat...

journal_title：Biochemical and biophysical research communications

authors： Liu W,Chen Y,Xu W,Wang W,Tang L,Xia R,Zhu Q

更新日期：2020-11-05 00:00:00

abstract：:The androgen receptor (AR) plays a central role in the development and progression of prostate cancer. AR expression is maintained throughout the progression of prostate cancer and is also associated with an aggressive, castration-resistant (CR) phenotype. Despite the critical roles of AR expression in prostate cancer...

journal_title：Biochemical and biophysical research communications

authors： Lee JW,Kim GY,Kim JH

更新日期：2012-04-06 00:00:00

abstract：:Heme oxygenase-1, an essential enzyme in heme catabolism, and metallothionein IIA, a small metal-binding protein with clusters of cysteins, are remarkably induced in HeLa cells following the treatment with cadmium or zinc. Both proteins are considered to be involved in the defense system against metal toxicity. Here w...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Fujita H,Shibahara S

更新日期：1995-02-06 00:00:00

abstract：:The interaction between histone H1 and non-histones HMG14 and HMG17 has been studied by chemical cross-linking. Cross-linking kinetics show the appearance of discrete bands which correspond to the interaction between H1 and HMG14. Interaction between H1 and HMG17 has not been detected. ...

journal_title：Biochemical and biophysical research communications

authors： Espel E,Bernués J,Querol E,Martínez P,Barris A,Lloberas J

更新日期：1983-12-28 00:00:00

abstract：:Calcium regulates diverse cellular activities in plants through the action of calmodulin (CaM). By using (35)S-labeled CaM to screen an Arabidopsis seedling cDNA expression library, a cDNA designated as AtCh-CPN10 (Arabidopsis thaliana chloroplast chaperonin 10) was cloned. Chloroplast CPN10, a nuclear-encoded protein...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Poovaiah BW

更新日期：2000-08-28 00:00:00

abstract：:There is considerable interest in the role of metals such as iron, copper, and zinc in amyloid plaque formation in Alzheimer's disease. However to convincingly establish their presence in plaques in vivo, a sensitive technique is required that is both quantitatively accurate and avoids isolation of plaques or staining...

journal_title：Biochemical and biophysical research communications

authors： Rajendran R,Minqin R,Ynsa MD,Casadesus G,Smith MA,Perry G,Halliwell B,Watt F

更新日期：2009-04-24 00:00:00

abstract：:Inflammatory bowel disease (IBD) comprises two major subtypes, ulcerative colitis (UC) and Crohn's disease, which are multifactorial diseases that may develop due to genetic susceptibility, dysbiosis, or environmental factors. Environmental triggers of IBD include food-borne factors, and a previous nationwide survey i...

journal_title：Biochemical and biophysical research communications

authors： Tsuchiya M,Ito G,Hama M,Nagata S,Kawamoto A,Suzuki K,Shimizu H,Anzai S,Takahashi J,Kuno R,Takeoka S,Hiraguri Y,Sugihara HY,Mizutani T,Yui S,Oshima S,Tsuchiya K,Watanabe M,Okamoto R

更新日期：2021-01-20 00:00:00

abstract：:Incubation of differentiated 3T3-L1 adipocytes with 0.5 mM dibutyryl cAMP plus 0.5 mM theophylline for 2 hours results in an 85% decrease in glycerol-3-phosphate dehydrogenase (G3PD) mRNA content. Incubation of the adipocytes with insulin (1 microgram/ml) up to 24 hrs yielded no significant change in the G3PD mRNA con...

journal_title：Biochemical and biophysical research communications

authors： Bhandari B,Miller RE

更新日期：1985-09-30 00:00:00

abstract：:Acetyl-CoA carboxylases (ACCs) have been highlighted as therapeutic targets for obesity and diabetes, as they play crucial roles in fatty acid metabolism. ACC activity is regulated through the short-term mechanism of inactivation by reversible phosphorylation. Here, we report the crystal structures of the biotin carbo...

journal_title：Biochemical and biophysical research communications

authors： Cho YS,Lee JI,Shin D,Kim HT,Jung HY,Lee TG,Kang LW,Ahn YJ,Cho HS,Heo YS

更新日期：2010-01-01 00:00:00

abstract：:The nonamer 5'd(CTCAGCCTC) 3' 1 has been reacted with cis-diamminediaquaplatinum(II) in water at pH 4.2. The major reaction product was shown by enzymatic digestion and 1H NMR to be the d(ApG)cis-Pt(NH3)2 chelate [cis-Pt(NH3)2[d(CTCAGCCTC)-N7(4),N7(5)]] 1-Pt. When mixed with its complementary strand 2, 1-Pt forms a B ...

journal_title：Biochemical and biophysical research communications

authors： Fouchet MH,Gauthier C,Guittet E,Girault JP,Igolen J,Chottard JC

更新日期：1992-01-31 00:00:00

abstract：:Atomic force microscopy (AFM) allows to study the molecular structure of biological macromolecules with nm to A resolutions without crystallization. We show here the applicability of AFM in the quantitative analysis of the molecular mechanisms of DNA/protein interaction: (i) Protein-binding sites can be mapped over a ...

journal_title：Biochemical and biophysical research communications

authors： Nettikadan S,Tokumasu F,Takeyasu K

更新日期：1996-09-24 00:00:00

abstract：:This study investigated the effects of shear stress on gene expression of prostacyclin synthesis-related enzymes cyclooxygenases (COX-1 and COX-2), prostacyclin synthase (PGS), and thromboxane synthase (TXS) and their metabolites prostaglandin (PGI(2)) and thromboxane A(2) (TXA(2)) in endothelium of intact conduit ves...

journal_title：Biochemical and biophysical research communications

authors： Doroudi R,Gan LM,Selin Sjögren L,Jern S

更新日期：2000-03-05 00:00:00

abstract：:Cytochrome c554 from the denitrifying bacterium Achromobacter cycloclastes is a monoheme class II c-type cytochrome with a His-Met axial coordination at neutral pH. The amino acid composition and the N-terminal sequence of the cytochrome have been determined. Subsequent determination of the pH-dependence of the redox ...

journal_title：Biochemical and biophysical research communications

authors： Saraiva LM,Thomson AJ,Le Brun NE,Liu MY,Payne WJ,LeGall J,Moura I

更新日期：1994-10-14 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a widely used tumor marker, is attached by a glycosylphosphatidylinositol (GPI) anchor motif to the cell membrane. Recent study suggested that membrane-bound CEA might be cleaved by glycosylphosphatidylinositol-phospholipase D (GPI-PLD). We studied the effect of GPI-PLD on the cleavage ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto Y,Hirakawa E,Mori S,Hamada Y,Kawaguchi N,Matsuura N

更新日期：2005-07-22 00:00:00

abstract：:The pluripotency of embryonic stem cells (ESCs) is maintained by core pluripotency transcription factors, cofactors and several signaling pathways. RBM14 is a component of the para-speckle complex, which has been implicated in multiple important biological processes. The role of RBM14 in ESCs and lineage differentiati...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Zhang D,Zhang L,Feng G,Zhang B,Wu Y,Li W,Zhang Y,Hu B

更新日期：2018-06-18 00:00:00

abstract：:We cloned a cDNA encoding a novel extracellular signal-regulated kinase (ERK) 2-binding protein, EBITEIN1, by yeast two-hybrid screening. Northern and Western blotting experiments showed that the transcript and protein were expressed in the testes. Furthermore, immunohistochemical experiments showed that EBITEIN1 exis...

journal_title：Biochemical and biophysical research communications

authors： Miura K,Imaki J

更新日期：2008-04-04 00:00:00

abstract：:RNA primer removal during DNA replication is dependent on ribonucleotide- and structure-specific RNase H and FEN-1 nuclease activities. A specific RNase H involved in this reaction has long been sought. RNase HII is the only open reading frame in Archaeoglobus fulgidus genome, while multiple RNases H exist in eukaryot...

journal_title：Biochemical and biophysical research communications

authors： Chai Q,Qiu J,Chapados BR,Shen B

更新日期：2001-09-07 00:00:00

abstract：:Yeast Ccc2 is a P-type ATPase responsible for transport of copper(I) from the cytosol to the trans-Golgi network. It possesses a soluble cytosolic N-terminal region containing two copper(I)-binding domains. Homologous eukaryotic copper-transporting ATPases have from one to six domains. We have expressed a fragment enc...

journal_title：Biochemical and biophysical research communications

authors： Banci L,Bertini I,Chasapis CT,Rosato A,Tenori L

更新日期：2007-12-21 00:00:00

abstract：:The exposure of hydrophobic sites on calmodulin, skeletal muscle troponin C and their tryptic fragments was investigated using Phenyl-Sepharose chromatography. A strong binding of both proteins and their fragments corresponding to the NH2-terminal halves of polypeptide chain of respective proteins in the presence of c...

journal_title：Biochemical and biophysical research communications

authors： Brzeska H,Szynkiewicz J,Drabikowski W

更新日期：1983-08-30 00:00:00

abstract：:Bovine thyroid 100,000 X g supernatant contained calcium-activated, calmodulin-dependent protein kinase (PK-CaM) activity. The PK-CaM was partially purified using ion-exchange chromatography and characterized. PK-CaM, using casein as exogenous substrate, was not stimulated by Ca2+(0-500 microM) or calmodulin (1-10 mic...

journal_title：Biochemical and biophysical research communications

authors： Friedman Y,Henricks L,Poleck T,Levasseur S,Burke G

更新日期：1986-10-15 00:00:00

abstract：:The effects of thyroid hormone on cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7 alpha hydroxylase responded the most rapidly and required the lowest dose of T3...

journal_title：Biochemical and biophysical research communications

authors： Ness GC,Pendleton LC,Li YC,Chiang JY

更新日期：1990-11-15 00:00:00

abstract：:Ap4A hydrolase (asymmetrical diadenosine tetraphosphate hydrolase, EC 3.6.1.17), an enzyme involved in a number of biological processes, is characterized as cleaving the polyphosphate chain at the fourth phosphate from the bound adenosine moiety. This paper presents the crystal structure of wild-type and E58A mutant h...

journal_title：Biochemical and biophysical research communications

authors： Ge H,Chen X,Yang W,Niu L,Teng M

更新日期：2013-03-01 00:00:00

abstract：:The RC2 antibody is widely used to label mouse radial glial cells in the developing central nervous system. While the antibody is known to recognize a 295-kDa intermediate filament proximal protein, the gene encoding the RC2 antigen remains to be identified. Here, we present evidences clearly demonstrating that Nestin...

journal_title：Biochemical and biophysical research communications

authors： Park D,Xiang AP,Zhang L,Mao FF,Walton NM,Choi SS,Lahn BT

更新日期：2009-05-08 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the dise...

journal_title：Biochemical and biophysical research communications

authors： Gopalan A,Bhagavat R,Chandra N,Subbarao SH,Raja A,Bethunaickan R

更新日期：2018-02-12 00:00:00

abstract：:Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study hypothesized that this adaptive response is mediated by increased mRNA of key genes central to the regulation of fat oxidati...

journal_title：Biochemical and biophysical research communications

authors： Tunstall RJ,Mehan KA,Hargreaves M,Spriet LL,Cameron-Smith D

更新日期：2002-06-07 00:00:00

abstract：:Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080 cells. Downregulation of Rac1 using specific siRNA probes result...

journal_title：Biochemical and biophysical research communications

authors： Niggli V,Schlicht D,Affentranger S

更新日期：2009-09-04 00:00:00

abstract：:Two new human genes encoding putative G protein-coupled receptors were cloned from genomic DNA following a degenerate PCR strategy. The predicted amino acid sequences of the proteins encoded by these genes have the characteristic motifs of chemokine receptors. This prompted us to name these genes CKR-L1 and CKR-L3. Ne...

journal_title：Biochemical and biophysical research communications

authors： Zaballos A,Varona R,Gutiérrez J,Lind P,Márquez G

更新日期：1996-10-23 00:00:00

abstract：:bis-cyclopentadienyl [Cp] complexes of vanadium(IV) or vanadocenes are rapid and potent inhibitors of human sperm motility with potential as a new class of contraceptive agents. We investigated the utility of boar sperm as a model system to study the mechanisms of drug action because boar sperm lacks phosphocreatine a...

journal_title：Biochemical and biophysical research communications

authors： D'Cruz OJ,Vassilev A,Uckun FM

更新日期：2000-04-21 00:00:00

abstract：:Evidence exists that the adenosine receptor A(2A)R and the dopamine receptor D(2)R form constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that an arginine-rich domain of the D(2)R third intracellular loop binds via electrostatic interactions to a specific motif of the A(2A)R C-termin...

journal_title：Biochemical and biophysical research communications

authors： Borroto-Escuela DO,Marcellino D,Narvaez M,Flajolet M,Heintz N,Agnati L,Ciruela F,Fuxe K

更新日期：2010-03-26 00:00:00

abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

journal_title：Biochemical and biophysical research communications

authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

更新日期：1994-12-15 00:00:00