Molecular cloning and RNA expression of two new human chemokine receptor-like genes.

abstract：:Comprehensive knowledge on the murine CT26 colon carcinoma line is a classic model used in the pharmacodynamic experiments involving IDO-1 inhibitors, immune-related checkpoint antibodies and immune related mechanisms. In this study, we determined the impact of different subcutaneous inoculation locations on tumor gro...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Yang Y,Xie J,Pan X,Yang X,Du Z,Hao E

更新日期：2019-04-30 00:00:00

abstract：:The reaction of the crosslinker dibromobimane has recently revealed a functionally important internal loop structure within the skeletal myosin S1 heavy chain where Cys-522 of the 50K domain and Cys-707 (SH1) of the 20K region are spatially juxtaposed. Here we have studied the possible relevance of this topological fe...

journal_title：Biochemical and biophysical research communications

authors： Bonet A,Audemard E,Mornet D

更新日期：1988-04-15 00:00:00

abstract：:The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami. Their amino acid sequences are DDTEDLANKFIGLM-NH(2) (named tachyk...

journal_title：Biochemical and biophysical research communications

authors： Li J,Liu T,Xu X,Wang X,Wu M,Yang H,Lai R

更新日期：2006-12-01 00:00:00

abstract：:Isolated nuclei from mammalian cells contain a Ca(2+)-dependent endonuclease [1]. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis [2]. We report here that zinc inhibits the DNA fragmentation in dependence of the free Ca2+ concentrations, suggesting that a balance bet...

journal_title：Biochemical and biophysical research communications

authors： Lohmann RD,Beyersmann D

更新日期：1993-02-15 00:00:00

abstract：:TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) administered to young male guinea pigs at a dose of 1 microgram/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity w...

journal_title：Biochemical and biophysical research communications

authors： Brewster DW,Matsumura F

更新日期：1984-07-31 00:00:00

abstract：:Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of...

journal_title：Biochemical and biophysical research communications

authors： Rossi L,Ciriolo MR,Marchese E,De Martino A,Giorgi M,Rotilio G

更新日期：1994-09-15 00:00:00

abstract：:Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-linked fucose to the ...

journal_title：Biochemical and biophysical research communications

authors： Ma L,Dong P,Liu L,Gao Q,Duan M,Zhang S,Chen S,Xue R,Wang X

更新日期：2016-04-29 00:00:00

abstract：:The coding sequence of type II phospholipase A2 from human placenta was cloned in a bovine papilloma virus-derived eukaryotic expression vector under the control of the metallothionein promoter. Stably transfected C127 mouse fibroblast lines were obtained with this vector. These transfected cells overexpressed a funct...

journal_title：Biochemical and biophysical research communications

authors： Pernas P,Masliah J,Olivier JL,Salvat C,Rybkine T,Bereziat G

更新日期：1991-08-15 00:00:00

abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

journal_title：Biochemical and biophysical research communications

authors： Mulder E,Vrij AA,Brinkmann AO

更新日期：1983-08-12 00:00:00

abstract：:Extensive evidence suggests that reactive oxygen species are critically involved in the pathogenesis of cardiovascular diseases, such as atherosclerosis and myocardial ischemia-reperfusion injury. Consistent with this concept, administration of exogenous antioxidants has been shown to be protective against oxidative c...

journal_title：Biochemical and biophysical research communications

authors： Cao Z,Li Y

更新日期：2002-03-22 00:00:00

abstract：:To investigate whether residues in the extracellular domains of melanocortin 1 receptor (MC1R) are required for ligand binding, a number of mutants were constructed where charged residues were converted to alanine. The residues targeted for mutagenesis were Ser6, Glu102, Arg109, Asp184, Glu269, and Thr272. The mutant ...

journal_title：Biochemical and biophysical research communications

authors： Chhajlani V,Xu X,Blauw J,Sudarshi S

更新日期：1996-02-15 00:00:00

abstract：:Styrene is an important chemical extensively used in the petrochemical and polymer industries. In Pseudomonas fluorescens ST, styrene metabolism is controlled by a two-component regulatory system, very uncommon in the degradation of aromatic compounds. The two-component regulatory proteins StyS and StyR regulate the e...

journal_title：Biochemical and biophysical research communications

authors： Leoni L,Ascenzi P,Bocedi A,Rampioni G,Castellini L,Zennaro E

更新日期：2003-04-11 00:00:00

abstract：:Capsaicin has been reported to regulate blood glucose levels and to ameliorate insulin resistance in obese mice. This study demonstrates that capsaicin increases glucose uptake directly by activating AMP-activated protein kinase (AMPK) in C2C12 muscle cells, which manifested as an attenuation of glucose uptake when co...

journal_title：Biochemical and biophysical research communications

authors： Kim SH,Hwang JT,Park HS,Kwon DY,Kim MS

更新日期：2013-09-13 00:00:00

abstract：:Ly6k, a putative mouse glycosylphosphatidyl-inositol (GPI)-anchored membrane protein is specifically associated with a unique germ-cell marker, TEX101. Although a human orthologue LY6K has been proposed as a novel cancer/testis antigen, its molecular nature is largely obscure, because its characteristics have been gle...

journal_title：Biochemical and biophysical research communications

authors： Maruyama M,Yoshitake H,Tsukamoto H,Takamori K,Araki Y

更新日期：2010-11-05 00:00:00

abstract：:Ubiquitin (Ub) carboxyl-terminal hydrolase L1 (UCH-L1) has dual functions, such as hydrolase activity on the chemical bonds formed by the C-terminal Gly of Ub and dimerization-dependent ubiquitin ligase activity. Accumulating evidence suggests that dual activities of UCH-L1 were intimately associated with Parkinson's ...

journal_title：Biochemical and biophysical research communications

authors： Park DW,Nam MK,Rhim H

更新日期：2011-11-11 00:00:00

abstract：:Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD(+)-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability,...

journal_title：Biochemical and biophysical research communications

authors： Lin J,Sun B,Jiang C,Hong H,Zheng Y

更新日期：2013-11-29 00:00:00

abstract：:Helodermin belongs to the VIP family of polypeptides. Recent in vivo data suggest that helodermin-like peptides might be involved in the regulation of calcium metabolism. We show that helodermin specifically binds to a secretin-type receptor in osteoblast-like cells from fetal rat calvaria and increases the basal and ...

journal_title：Biochemical and biophysical research communications

authors： Pfeilschifter J,Naumann A,Oechsner M,Ziegler R

更新日期：1990-07-31 00:00:00

abstract：:The corticotropin releasing factor (CRF) plays a central role in regulating the activities of hypothalamic-pituitary-adrenal (HPA) axis in the presence of a variety of stressful stimuli via binding to its type 1 receptors (CRFR1). Despite that many peptidic or non-peptidic antagonists of CRFR1 have been developed to s...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Zhuo R,Peng P,Liu X,Yan H,Zhang S,Zheng J,Wei X,Ma X

更新日期：2015-07-31 00:00:00

abstract：:Growing evidences show that functionally relevant polymorphisms in various promoters alter both transcriptional activity and affinities of existing protein-DNA interactions, and thus influence disease progression in humans. We previously reported the -94G>T CFTR promoter variant in a female CF patient in whom any know...

journal_title：Biochemical and biophysical research communications

authors： Taulan M,Lopez E,Guittard C,René C,Baux D,Altieri JP,DesGeorges M,Claustres M,Romey MC

更新日期：2007-09-28 00:00:00

abstract：:Casper/c-FLIP is a caspase-8-related molecule critically involved in regulation of death receptor-induced apoptosis. It has been shown that Casper can either promote or antagonize apoptosis and can activate the transcription factor NF-kappaB. The exact functions of Casper are controversial. To further understand how C...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Zhang J,Chen D,Shu HB

更新日期：2003-10-03 00:00:00

abstract：:We recently reported enhanced tumor growth and stimulation of vascular endothelial growth factor (VEGF) expression in rat mammary carcinoma cells transfected with a human tissue inhibitor of metalloproteinases-1 (hTIMP-1) cDNA (1). In the present study, we examined if the composition of the stroma was altered in the t...

journal_title：Biochemical and biophysical research communications

authors： Yoshiji H,Buck TB,Harris SR,Ritter LM,Lindsay CK,Thorgeirsson UP

更新日期：1998-06-29 00:00:00

abstract：:Porins are trimeric proteins in the outer membranes of Gram-negative bacteria. Several of them, among them matrix porin of Escherichia coli, form symmetrically voltage-gated ion channels in planar bilayers. Trimers exhibit negative resistance at potentials larger than +/- 90mV. Here we show that, after two pores withi...

journal_title：Biochemical and biophysical research communications

authors： Buehler LK,Rosenbusch JP

更新日期：1993-01-29 00:00:00

abstract：:We found that rat bone marrow-derived macrophages responded to opsonized zymosan by releasing superoxide anion. However, these cells were defective in the response to the potent oxidative burst activator phorbol myristate acetate (PMA). This result was observed whatever the concentration of agonist used and with diffe...

journal_title：Biochemical and biophysical research communications

authors： Andre P,Capo C,Mege JL,Benoliel AM,Bongrand P

更新日期：1988-03-15 00:00:00

abstract：:We have previously reported that endothelin-1 (ET-1) stimulates interleukin-6 (IL-6), a potent bone resorptive agent, through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the involvement of Rho-kinase in the ET-1-stimulated I...

journal_title：Biochemical and biophysical research communications

authors： Tokuda H,Hanai Y,Matsushima-Nishiwaki R,Yamauchi J,Doi T,Harada A,Takai S,Kozawa O

更新日期：2007-11-03 00:00:00

abstract：:Growth and differentiation factors (GDF)-5, -6, and -7 are members of the bone morphogenetic protein (BMP) family. Previous studies suggest their importance in bone development and in tendon/ligament morphogenesis. The cells of the dental attachment apparatus, cementum, periodontal ligament, and alveolar bone proper a...

journal_title：Biochemical and biophysical research communications

authors： Morotome Y,Goseki-Sone M,Ishikawa I,Oida S

更新日期：1998-03-06 00:00:00

abstract：:A general method to obtain the variable region DNA sequence of the immunoglobulin heavy chain using anchored polymerase chain reaction is described. Based on this DNA sequence, clone-specific oligonucleotides were designed to anneal to the complementarity determining regions. These were used to identify the original B...

journal_title：Biochemical and biophysical research communications

authors： Ratech H

更新日期：1992-02-14 00:00:00

abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

journal_title：Biochemical and biophysical research communications

authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

更新日期：2005-10-28 00:00:00

abstract：:Acinetobacter lwoffii K24 known as an aniline degrading bacterium has also been found to utilize p-hydroxybenzoate as a sole carbon source. In this study, 2-DE using Q-Sepharose column separation was attempted for fast screening of protocatechuate 3,4-dioxygenase for catabolism of p-hydroxybenzoate in A. lwoffii K24. ...

journal_title：Biochemical and biophysical research communications

authors： Kahng HY,Cho K,Song SY,Kim SJ,Leem SH,Kim SI

更新日期：2002-07-26 00:00:00

abstract：:We have previously shown that Hes1 is expressed both in putative epithelial stem cells just above Paneth cells and in the crypt base columnar cells between Paneth cells, while Hes1 is completely absent in Paneth cells. This study was undertaken to clarify the role of Hes1 in Paneth cell differentiation, using Hes1-kno...

journal_title：Biochemical and biophysical research communications

authors： Suzuki K,Fukui H,Kayahara T,Sawada M,Seno H,Hiai H,Kageyama R,Okano H,Chiba T

更新日期：2005-03-04 00:00:00

abstract：:Epinephrine is known to be rapidly oxidized during sepsis. Ischemia and acidosis, which often accompany sepsis, are associated with the release of weakly bound cupric ions from plasma proteins. We investigated whether copper promotes oxidation of epinephrine at both physiological and acidic pH and whether D-Asp-D-Ala-...

journal_title：Biochemical and biophysical research communications

authors： Roberts A,Bar-Or D,Winkler JV,Rael LT

更新日期：2003-05-16 00:00:00