当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.

Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.

Abstract：

:We have previously shown that Hes1 is expressed both in putative epithelial stem cells just above Paneth cells and in the crypt base columnar cells between Paneth cells, while Hes1 is completely absent in Paneth cells. This study was undertaken to clarify the role of Hes1 in Paneth cell differentiation, using Hes1-knockout (KO) newborn (P0) mice. Electron microscopy revealed premature appearance of distinct cells containing cytoplasmic granules in the intervillous region in Hes1-KO P0 mice, whereas those cells were absent in wild-type (WT) P0 mice. In Hes1-KO P0 mice, the gene expressions of cryptdins, exclusively present in Paneth cells, were all enhanced compared with WT P0 mice. Immunohistochemistry demonstrated increased number of both lysozyme-positive and cryptdin-4-positive cells in the small intestinal epithelium of Hes1-KO P0 mice as compared to WT P0 mice. Thus, Hes1 appears to have an inhibitory role in Paneth cell differentiation in the small intestine.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki K,Fukui H,Kayahara T,Sawada M,Seno H,Hiai H,Kageyama R,Okano H,Chiba T

doi

10.1016/j.bbrc.2004.12.174

subject

Has Abstract

pub_date

2005-03-04 00:00:00

pages

348-52

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02986-9

journal_volume

328

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Synergism of vitamins A and C on fibrinolysis.

    abstract：:A hitherto unknown synergism exerted by retinol (vitamin A) and L-ascorbic acid (vitamin C) was discovered using endothelial cells. Retinol stimulated the extracellular and intracellular activities of plasminogen activator up to approximately 8- and 4-fold from the control values, respectively. L-Ascorbic acid enhance...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90399-7

    authors： Inada Y,Hagiwara H,Kojima S,Shimonaka M,Saito Y

    更新日期：1985-07-16 00:00:00

  • Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme.

    abstract：:Xanthine oxidase (XO) was found to convert nitric oxide (NO* ) released from spermine-NONOate to nitroxyl (HNO), the one-electron reduction product of NO*, in the presence of its substrate hypoxanthine under anaerobic conditions. Under these conditions, XO lost its activity. Upon aerobic incubation of XO with its subs...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.081

    authors： Saleem M,Ohshima H

    更新日期：2004-03-05 00:00:00

  • β-elemene inhibits tumor-promoting effect of M2 macrophages in lung cancer.

    abstract：:Macrophages in tumor are mostly M2-polarized and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). β-elemene has therapeutic effects against several cancers, however, it remains unknown whether β-elemene could inhibit cancer by targeting TAMs. Herein, we examin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.071

    authors： Yu X,Xu M,Li N,Li Z,Li H,Shao S,Zou K,Zou L

    更新日期：2017-08-19 00:00:00

  • A novel and potent ribonuclease from fruiting bodies of the mushroom Pleurotus pulmonarius.

    abstract：:A ribonuclease (RNase), with an N-terminal sequence different from those of ribonucleases from the mushrooms Irpex lacteus, Lentinus edodes, Pleurotus ostreatus, Pleurotus tuber-regium, and Volvariella volvacea, was purified from fruiting bodies of the edible mushroom Pleurotus pulmonarius. The N-terminal sequence of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00301-7

    authors： Ye XY,Ng TB

    更新日期：2002-05-03 00:00:00

  • Markedly decreased binding of vincristine to tubulin in vinca alkaloid-resistant Chinese hamster cells is associated with selective overexpression of alpha and beta tubulin isoforms.

    abstract：:Vinca alkaloids are among a number of cytotoxic agents which target tumor cell microtubules. Studies described herein document the basis for one form of acquired resistance to these plant alkaloids involving an alteration of tubulin in a variant (DC-3F/VCRd-5L) of DC-3F Chinese hamster cells. Our results revealed a ma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2246

    authors： Sirotnak FM,Danenberg KD,Chen J,Fritz F,Danenberg PV

    更新日期：2000-03-05 00:00:00

  • Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.

    abstract：:Rab7, a member of the Rab family small G proteins, is involved in the late stage of the endocytic pathway. We previously identified a Rab7 target protein, Rabring7, which contains a RING finger domain at its C termini, but the precise role of Rabring7 remains unknown. In this study, we demonstrate using an in vitro ub...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.04.052

    authors： Sakane A,Hatakeyama S,Sasaki T

    更新日期：2007-06-15 00:00:00

  • On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.

    abstract：:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. Howev...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.11.117

    authors： Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

    更新日期：2021-01-01 00:00:00

  • Computational analysis of the extracellular domain of the Ca²⁺-sensing receptor: an alternate model for the Ca²⁺ sensing region.

    abstract：:The extracellular Ca(2+) sensing receptor (CaSR) belongs to Class C G-protein-coupled receptors (GPCRs) which include receptors for amino acids, γ-aminobutyric acid and glutamate neurotransmitters. CaSR has been described as having an extended sequence containing a Ca(2+) binding pocket within an extracellular amino (...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.049

    authors： Morrill GA,Kostellow AB,Gupta RK

    更新日期：2015-03-27 00:00:00

  • Sir2 is involved in the transcriptional modulation of NHP6A in Saccharomyces cerevisiae.

    abstract：:The Sir proteins, namely Sir2, 3 and 4, have roles related to heterochromatin, but genome-wide studies have revealed their presence at many euchromatic loci, although the functional meaning of this is still not clear. Nhp6a is an abundant HMG-like protein in yeast, which has a role in transcription by modulating chrom...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.03.165

    authors： Ciuffetta A,Salerno D,Camilloni G,Venditti S

    更新日期：2015-05-22 00:00:00

  • Inhibition of cell death-inducing p53 target 1 through miR-210-3p overexpression attenuates reactive oxygen species and apoptosis in rat adipose-derived stem cells challenged with Angiotensin II.

    abstract：:Hypoxic preconditioning is a well-known strategy to improve the survival and therapeutic potential of stem cells against various challenges including hemodynamic and neurohormonal modulations. However, the mechanism involved in hypoxia-induced benefits on stem cells is still ambiguous. In pathological hypertension, th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.07.052

    authors： Lai CH,Barik P,Hsieh DJ,Day CH,Ho TJ,Chen RJ,Kuo WW,Padma VV,Shibu MA,Huang CY

    更新日期：2020-11-12 00:00:00

  • Evidence for an inactive plasma membrane-associated precursor of active cytoplasmic ornithine decarboxylase in developing embryos of Musca domestica.

    abstract：:During embryonic development of Musca domestica inactive ornithine decarboxylase protein appears in the embryos at 6 h postoviposition, increases in concentration and reaches a maximum level at 9 h postoviposition. The inactive enzyme is associated with the plasma membrane and appears to be the precursor for active or...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91444-h

    authors： Lilleberg SL,Killilea SD,Vaske DA,Leopold RA,Sparks RB Jr

    更新日期：1991-01-31 00:00:00

  • Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein.

    abstract：:The E. coli ogt O6-alkylguanine-DNA alkyltransferase has two cysteine residues positioned identically with respect to cysteines in the E. coli ada O6-alkylguanine-DNA alkyltransferase. In order to assess their function, these residues were each substituted by a glycine to generate altered forms of the ogt protein. Mut...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81510-4

    authors： Harris LC,Potter PM,Margison GP

    更新日期：1992-08-31 00:00:00

  • Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma.

    abstract：:The retinoid-related orphan receptor gamma (RORgamma) has been shown to function as a positive regulator of transcription in many cell lines. Transcriptional activation by nuclear receptors involves recruitment of co-activators that interact with receptors through their LXXLL motifs (NR box). In this study, we analyze...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.131

    authors： Kurebayashi S,Nakajima T,Kim SC,Chang CY,McDonnell DP,Renaud JP,Jetten AM

    更新日期：2004-03-19 00:00:00

  • Effect of ELOVL3 expression on bovine skeletal muscle-derived satellite cell differentiation.

    abstract：:ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.07.118

    authors： Liu D,Xu JH,Tong HL,Li SF,Yan YQ

    更新日期：2017-12-02 00:00:00

  • Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.

    abstract：:C(2)-ceramide, a cell-permeable analog of ceramide, caused cell death in cultured rat cortical neuronal cells. C(2)-ceramide-induced neuronal loss was accompanied by upregulation of caspase-3 activity, measured by cleavage of its fluorogenic substrate Ac-DEVD-AMC. Similar results were obtained when cortical neuronal c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02593-7

    authors： Movsesyan VA,Yakovlev AG,Dabaghyan EA,Stoica BA,Faden AI

    更新日期：2002-11-29 00:00:00

  • Limitations imposed by heteroduplex formation on quantitative RT-PCR.

    abstract：:RT-PCR, a rapidly emerging technique for the detection of RNA, is being used by many investigators to quantify small amounts of RNA. Accurate quantification of RNA content has been facilitated by the use of competitive amplicons as internal controls. We demonstrate that losses in sensitivity and accuracy are associate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1319

    authors： Henley WN,Schuebel KE,Nielsen DA

    更新日期：1996-09-04 00:00:00

  • Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.

    abstract：:The calcium homeostasis of the endoplasmic reticulum (ER) is connected to a multitude of cell functions involved in intracellular signal transduction, control of proliferation, programmed cell death, or the synthesis of mature proteins. Calcium is accumulated in the ER by various biochemically distinct sarco/endoplasm...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2004.08.030

    authors： Papp B,Brouland JP,Gélébart P,Kovàcs T,Chomienne C

    更新日期：2004-10-01 00:00:00

  • Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma.

    abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.06.021

    authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

    更新日期：2013-07-12 00:00:00

  • Identification and functional characterization of three type III polyketide synthases from Aquilaria sinensis calli.

    abstract：:Type III polyketide synthases (PKSs) play an important role in biosynthesis of various plant secondary metabolites and plant adaptation to environmental stresses. Aquilaria sinensis (A. sinensis) is the main plant species for production of agarwood, little is known about its PKS family. In this study, AsCHS1 and two n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.159

    authors： Wang X,Zhang Z,Dong X,Feng Y,Liu X,Gao B,Wang J,Zhang L,Wang J,Shi S,Tu P

    更新日期：2017-05-13 00:00:00

  • Circadian expression of clock and screening of clock-controlled genes in peripheral lymphocytes of rat.

    abstract：:In this paper, the circadian pattern of Clock and genes mediated by the Clock was investigated in peripheral lymphocytes of rats. Circadian rhythms of Clock are found under the regimes of constant darkness (DD) and 12-h light-12-h dark (LD12:12h), with the peak phase at CT7 and ZT21, respectively. Ten differential cDN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.228

    authors： Du YZ,Fan SJ,Meng QH,Wang GQ,Tong J

    更新日期：2005-11-04 00:00:00

  • The appearance of phospholipase activity in the human macrophage-like cell line U937 during dimethyl sulfoxide induced differentiation.

    abstract：:The human histiocyte cell line, U937, with monocyte characteristics, can be induced to differentiate into macrophage-like cells when exposed to growth medium containing 1.5% DMSO. Following three days of exposure, DMSO-treated but not control U937 cells can be stimulated to release endogenous arachidonic acid from the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91089-1

    authors： Myers RF,Siegel MI

    更新日期：1984-01-13 00:00:00

  • Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle.

    abstract：:There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high de...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.07.140

    authors： Shin JY,Shin JI,Kim JS,Yang YS,Hwang Y,Yang JS,Shin D,Seo JH,Jin YS,Park YC,Hwang JS,Kweon DH

    更新日期：2009-10-16 00:00:00

  • Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides.

    abstract：:In order to investigate the utility of intranasal administration of peptides for systemic medication, the nasal absorption of the model peptide, leucine enkephalin (Tyr-Gly-Gly-Phe-Leu), was studied in the rat. At a concentration of 60 micrograms/ml in Ringer's buffer the pentapeptide was found to undergo, extensive h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91224-0

    authors： Hussain A,Faraj J,Aramaki Y,Truelove JE

    更新日期：1985-12-31 00:00:00

  • The role of arterial smooth muscle in vasorelaxation.

    abstract：:The concept of endothelium-derived relaxing factor (EDRF) implies that nitric oxide (NO) produced by NO synthase (NOS) in the endothelium in response to vasorelaxants such as acetylcholine (ACh) acts on the underlying vascular smooth muscle cells (VSMC) inducing vascular relaxation. The EDRF concept was derived from e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.019

    authors： Buchwalow IB,Cacanyiova S,Neumann J,Samoilova VE,Boecker W,Kristek F

    更新日期：2008-12-12 00:00:00

  • A superactive peptidomimetic analog of a farnesylated dodecapeptide yeast pheromone.

    abstract：:The S. cerevisiae a-factor, YIIKGVFWDPAC(s-farnesyl)-OCH3, is one of two peptide mating pheromones which mediate cell-cell communication in S. cerevisiae. We previously reported that replacing Gly5 with D-Ala led to a 4-6 fold increase in activity while the L-Ala5 homolog was 4 to 16-fold less active than the wildtype...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1028

    authors： Zhang YL,Dawe AL,Jiang Y,Becker JM,Naider F

    更新日期：1996-07-16 00:00:00

  • Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

    abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is known to reduce hepatic low-density lipoprotein receptor (LDLR) levels and increase plasma LDL cholesterol. It is not clear, however, whether secreted PCSK9 degrades extrahepatic LDLRs. We present evidence that recombinant PCSK9, either...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.04.004

    authors： Schmidt RJ,Beyer TP,Bensch WR,Qian YW,Lin A,Kowala M,Alborn WE,Konrad RJ,Cao G

    更新日期：2008-06-13 00:00:00

  • Regulatory effect of the glial Golli-BG21 protein on the full-length murine small C-terminal domain phosphatase (SCP1, or Golli-interacting protein).

    abstract：:The gene in the oligodendrocyte lineage (golli) encodes a number of proteins essential for myelination, comprising Golli and classic isoforms that are expressed in a developmentally-regulated manner. The Golli-interacting-protein (GIP) was previously discovered in a search for potential interacting partners of the Gol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.050

    authors： Jaramillo-Tatis S,Vassall KA,Bamm VV,Harauz G

    更新日期：2014-05-16 00:00:00

  • The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier.

    abstract：:The brain-type glucose transporter (bGT) is assumed to be distributed among neurons and glial cells, but to be particularly enriched in brain microvascular endothelium, which makes up the blood-brain barrier (BBB) in vivo. However, in the course of the present studies it was found that the bGT is specifically expresse...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91927-k

    authors： Boado RJ,Pardridge WM

    更新日期：1990-01-15 00:00:00

  • A telomerase-derived peptide regulates reactive oxygen species and hepatitis C virus RNA replication in HCV-infected cells via heat shock protein 90.

    abstract：:GV1001, a synthetic peptide derived from human telomerase, has a range of diverse biological activities, including an antioxidant function. Here, we investigated the role of GV1001 in hepatitis C virus (HCV)-infected Huh7.5 (JFH-1) cells. We showed that GV1001 inhibited the production of ROS with decreased MAP kinase ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.160

    authors： Lee SA,Kim J,Sim J,Kim SG,Kook YH,Park CG,Kim HR,Kim BJ

    更新日期：2016-02-26 00:00:00

  • Different microvascular permeability responses elicited by the CXC chemokines MIP-2 and KC during leukocyte recruitment: role of LSP1.

    abstract：:The CXC chemokines keratinocyte-derived chemokine (KC, CXCL1) and macrophage inflammatory protein-2 (MIP-2, CXCL2) activate G-protein coupled receptor CXCR2 and are believed to have similar inflammatory effects in mice. Their specific signaling mechanisms remain elusive. A wide variety of cellular events, mediators an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.146

    authors： Lei X,Hossain M,Qadri SM,Liu L

    更新日期：2012-07-06 00:00:00