当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.

On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.

Abstract：

:Cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, is a target of thalidomide and thalidomide-derived immunomodulatory drugs (IMiDs). The binding of these IMiDs to CRBN alters the substrate specificity of the ligase, thereby mediating multiple effects that are exploited in cancer therapy. However, to date, it is not clear which other possible targets might be involved in the efficacy of IMiDs. One especially prominent effect of a number of thalidomide analogs is their ability to inhibit angiogenesis, which is typically enhanced in fluorinated analogs. So far, the involvement of CRBN in antiangiogenic effects is under debate. Here, starting from a systematic set of thalidomide analogs and employing a quantitative in vitro CRBN-binding assay, we study the correlation of fluorination, CRBN binding and antiangiogenic effects. We clearly identify fluorination to correlate both with CRBN binding affinity and with antiangiogenic effects, but do not find a correlation between the latter two phenomena, indicating that the main target for the antiangiogenic effects of thalidomide analogs still remains to be identified.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Heim C,Maiwald S,Steinebach C,Collins MK,Strope J,Chau CH,Figg WD,Gütschow M,Hartmann MD

doi

10.1016/j.bbrc.2020.11.117

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

67-72

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)32161-6

journal_volume

534

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • A study of the mitochondrial F1-ATPase tryptophan phosphorescence at 273 K.

    abstract：:The bovine heart mitochondrial F1-ATPase complex exhibits an intrinsic tryptophan phosphorescence that can be used to monitor structural changes of the epsilon-subunit. The phosphorescence decay rate of F1 containing the tightly bound nucleotides increases upon addition of adenine nucleoside triphosphate in the presen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1197

    authors： Baracca A,Barogi S,Gabellieri E,Lenaz G,Solaini G

    更新日期：1995-02-06 00:00:00

  • Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes.

    abstract：:VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation. However, the role of the beta-domain, which may recognize the target proteins for protein degradation, remains ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1347

    authors： Okuda H,Hirai S,Takaki Y,Kamada M,Baba M,Sakai N,Kishida T,Kaneko S,Yao M,Ohno S,Shuin T

    更新日期：1999-09-24 00:00:00

  • Catabolism of pentachlorophenol by a Flavobacterium sp.

    abstract：:The pathway employed for pentachlorophenol (PCP) degradation by an aerobic, chlorophenol-utilizing Flavobacterium sp. was initiated by conversion of PCP to tetrachloro-p-hydroquinone (TCH). 18O labelling experiments demonstrated that the first dechlorination, where a hydroxyl replaced the chlorine at PCP ring position...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80247-9

    authors： Steiert JG,Crawford RL

    更新日期：1986-12-15 00:00:00

  • Cell surface n-acetylneuraminic acid alpha2,3-galactoside-dependent intercellular adhesion of human colon cancer cells.

    abstract：:Sialoglycans on the cell surface of human colon cancer (HCC) cells have been implicated in cellular adhesion and metastasis. To clarify the role of N-acetylneuraminic acid (NeuAc) linked alpha2,3 to galactose (Gal) on the surface of HCC cells, we studied the intercellular adhesion of HCC cell lines expressing increasi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0388

    authors： Dimitroff CJ,Pera P,Dall'Olio F,Matta KL,Chandrasekaran EV,Lau JT,Bernacki RJ

    更新日期：1999-03-24 00:00:00

  • In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF.

    abstract：:DmTTF is a Drosophila melanogaster mitochondrial DNA-binding protein which binds specifically to two homologous non-coding sequences located at the 3' ends of blocks of genes encoded on opposite strands. In order to test whether this protein acts as transcription termination factor, we assayed the capacity of DmTTF to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.173

    authors： Roberti M,Fernandez-Silva P,Polosa PL,Fernandez-Vizarra E,Bruni F,Deceglie S,Montoya J,Gadaleta MN,Cantatore P

    更新日期：2005-05-27 00:00:00

  • Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells.

    abstract：:MUC1 is abundantly expressed at the surface of epithelial cells in many tissues and their carcinomas. In humans, genetic polymorphism and differential splicing produce isoforms that may contribute to MUC1 participation in protection of the cell surface, modulation of cell-cell interactions, signaling, and metastasis. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00352-2

    authors： Julian J,Carson DD

    更新日期：2002-05-17 00:00:00

  • Effect of triiodothyronine on muscle cell differentiation and blood glucose level in hyperglycemic KK mice.

    abstract：:KK mice are genetically diabetic animals, showing glucose intolerance and insulin resistance. We examined the effects of 3,3',5-triiodo-L-thyronine (T3) on the blood glucose level and on mRNA levels of muscle cell differentiation markers in hyperglycemic KK mice. T3 treatment (T1, 1 mg; T3, 3 mg; T10, 10 mg/kg/day) of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6882

    authors： Shimokawa T,Kato M,Shioduka K,Irie J,Ezaki O

    更新日期：1997-06-27 00:00:00

  • Spectra of chloroperoxidase compounds II and III.

    abstract：:Chloroperoxidase was present as Compound II during the peroxidatic oxidation of ascorbic acid. Compound III (oxy-form) was formed when excess hydrogen peroxide was added to Compound II. By decreasing the temperature it was possible to measure the spectra of Compounds II and III in the Soret and visible regions. Each s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91635-3

    authors： Nakajima R,Yamazaki I,Griffin BW

    更新日期：1985-04-16 00:00:00

  • Identification of a long form of cystatin from human saliva by rapid microbore HPLC mapping.

    abstract：:Microbore HPLC methodology permits rapid and sensitive mapping of human saliva proteins. Saliva is sampled and processed in less than one hour, greatly reducing the likelihood of artifactual protein degradation. As little as 50 microliters of saliva yields proteins in sufficient quantities and purity to obtain amino t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91571-3

    authors： Hawke DH,Yuan PM,Wilson KJ,Hunkapiller MW

    更新日期：1987-06-30 00:00:00

  • Longistatin, a novel plasminogen activator from vector ticks, is resistant to plasminogen activator inhibitor-1.

    abstract：:Thrombo-occlusive diseases are major causes of morbidity and mortality, and tissue-type plasminogen activator (t-PA) is recommended for the treatment of the maladies. However, both t-PA and u-PA are rapidly inactivated by plasminogen activator inhibitor-1 (PAI-1). Here, we show that longistatin, a novel plasminogen ac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.09.009

    authors： Anisuzzaman,Khyrul Islam M,Abdul Alim M,Miyoshi T,Hatta T,Yamaji K,Matsumoto Y,Fujisaki K,Tsuji N

    更新日期：2011-10-07 00:00:00

  • Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor.

    abstract：:T-type Ca(2+) channels have been implicated in tremorogenesis and motor coordination. The α1 subunit of the Ca(V)3.1 T-type Ca(2+) channel is highly expressed in motor pathways in the brain, but knockout of the Ca(V)3.1 gene (α(1G)(-/-)) per se causes no motor defects in mice. Thus, the role of Ca(V)3.1 channels in mo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.082

    authors： Chang KY,Park YG,Park HY,Homanics GE,Kim J,Kim D

    更新日期：2011-06-24 00:00:00

  • Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene.

    abstract：:Mutations in human BIGH3 (TGFB1), a gene identified after treatment of an adenocarcinoma cell line with TGF-beta, have been observed in patients with granular Groenouw type I, Reis-Bücklers, Thiel-Behnke, Avellino, and Lattice type I and IIIa, six autosomal dominant corneal dystrophies linked to chromosome 5q. In orde...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3116

    authors： Schorderet DF,Menasche M,Morand S,Bonnel S,Büchillier V,Marchant D,Auderset K,Bonny C,Abitbol M,Munier FL

    更新日期：2000-08-02 00:00:00

  • Mitochondrial malate dehydrogenase and its precursor have different conformations.

    abstract：:Antiserum prepared against the denatured form of mammalian malate dehydrogenase was found to immunoprecipitate the denatured but not the native form of the mature enzyme. In contrast, the antiserum immunoprecipitated the enzyme's precursor, synthesized in a rabbit reticulocyte lysate, either before or after denaturati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80370-9

    authors： Chien SM,Freeman KB

    更新日期：1986-11-26 00:00:00

  • Pak regulates calpain-dependent degradation of E3b1.

    abstract：:E3b1, a binding partner of Eps8, plays a critical role in receptor tyrosine kinase (RTK)-mediated Rac activation by facilitating the interaction of Eps8 with Sos-1 and the consequent activation of the Rac-specific guanine nucleotide exchange factor activity of Sos-1. Here we present evidence that E3b1 levels are regul...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.042

    authors： Chi S,Chang S,Park D

    更新日期：2004-06-25 00:00:00

  • Unexpected blockade of adipocyte differentiation by K-7174: implication for endoplasmic reticulum stress.

    abstract：:Preadipocytes constitutively express GATA-2 and GATA-3 that are required to halt the cells at the undifferentiated stage. However, we unexpectedly found that K-7174, a GATA-specific inhibitor, did not induce but rather inhibited differentiation of 3T3-L1 preadipocytes. It was associated with lack of lipid accumulation...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.167

    authors： Shimada T,Hiramatsu N,Okamura M,Hayakawa K,Kasai A,Yao J,Kitamura M

    更新日期：2007-11-16 00:00:00

  • Human bronchial epithelial cells express and secrete MMP-12.

    abstract：:Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins, which may be responsible for enlargement of alveoli in chronic obstructive pulmonary disease (COPD) and remodeling of pulmonary tissue associated with chronic asthma. Here, we provide novel evidence that MMP-12 is expressed and secreted by normal ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.080

    authors： Lavigne MC,Thakker P,Gunn J,Wong A,Miyashiro JS,Wasserman AM,Wei SQ,Pelker JW,Kobayashi M,Eppihimer MJ

    更新日期：2004-11-12 00:00:00

  • Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division.

    abstract：:Emp, originally detected in erythroblastic islands, is expressed in numerous cell types and tissues suggesting a functionality not limited to hematopoiesis. To study the function of Emp in non-hematopoietic cells, an epitope-tagged recombinant human Emp was expressed in HEK cells. Preliminary studies revealed that Emp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.02.060

    authors： Bala S,Kumar A,Soni S,Sinha S,Hanspal M

    更新日期：2006-04-21 00:00:00

  • Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus.

    abstract：:The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act as capture receptors...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.10.106

    authors： Martinez MG,Bialecki MA,Belouzard S,Cordo SM,Candurra NA,Whittaker GR

    更新日期：2013-11-22 00:00:00

  • Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols.

    abstract：:Endothelin tightly bound to rabbit aortic strips and caused a prolonged vasoconstriction both in the presence and absence of extracellular Ca2+, although only partial constriction (20-30%) developed in the latter case, indicating that its action may not be limited to the opening of a calcium channel. The endothelin-in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80193-7

    authors： Sugiura M,Inagami T,Hare GM,Johns JA

    更新日期：1989-01-16 00:00:00

  • Cellular and molecular biology of prostacyclin synthase.

    abstract：:Prostacyclin synthase (PGIS) cDNA comprises 1500 nucleotides coding for a 500 amino acid protein. It is a heme protein with spectral characteristics of cytochrome p450 (CYP). It does not possess the typical CYP mono-oxygenase activity but catalyzes the rearrangement of prostaglandin H2 to form PGI2. Analysis of its st...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2005.08.021

    authors： Wu KK,Liou JY

    更新日期：2005-12-09 00:00:00

  • Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

    abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is known to reduce hepatic low-density lipoprotein receptor (LDLR) levels and increase plasma LDL cholesterol. It is not clear, however, whether secreted PCSK9 degrades extrahepatic LDLRs. We present evidence that recombinant PCSK9, either...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.04.004

    authors： Schmidt RJ,Beyer TP,Bensch WR,Qian YW,Lin A,Kowala M,Alborn WE,Konrad RJ,Cao G

    更新日期：2008-06-13 00:00:00

  • CD99 mediates neutrophil transmigration through the bEnd.3 monolayer via the induction of oxygen-glucose deprivation.

    abstract：AIM/BACKGROUND:CD99 participate in neutrophil infiltration after inflammatory events; however, despite the important role of inflammation in ischemic stroke, the role of CD99 in ischemic stroke remains unclear. METHOD:In the present study, we detected the protein expression of CD99, ICAM-1, and CD31 (PECAM-1) in oxyge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.03.159

    authors： Hu T,Sun R,Huang F,Liu X,Duan Z,Ye R,Li Y,Xiao L,Guo Z,Liu Q,Zhu W

    更新日期：2020-06-04 00:00:00

  • Morin suppresses cachexia-induced muscle wasting by binding to ribosomal protein S10 in carcinoma cells.

    abstract：:Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. In this study, we examined the e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.10.184

    authors： Yoshimura T,Saitoh K,Sun L,Wang Y,Taniyama S,Yamaguchi K,Uchida T,Ohkubo T,Higashitani A,Nikawa T,Tachibana K,Hirasaka K

    更新日期：2018-12-02 00:00:00

  • Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes.

    abstract：:Imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to beta-lactam antibiotic group and to chemically unrelated ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00074-3

    authors： Bornet C,Chollet R,Malléa M,Chevalier J,Davin-Regli A,Pagès JM,Bollet C

    更新日期：2003-02-21 00:00:00

  • Prevention of quinone-mediated DNA arylation by antioxidants.

    abstract：:High performance liquid chromatographic (HPLC) analysis showed that the prototype antioxidant ascorbate (vitamin C) inhibits the DNA adducts induced by synthetic estrogen diethylstilbestrol (DES) and the antiestrogen metabolite 4-hydroxytamoxifen (4-OHTam). Treatment of salmon testes DNA with 4-OHTam quinone or 4-OHTa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1290

    authors： Sharma M,Slocum HK

    更新日期：1999-09-07 00:00:00

  • Inhibition of mitochondrial translation effectively sensitizes renal cell carcinoma to chemotherapy.

    abstract：:The functional importance of mitochondrial protein translation has been recently documented in the context of various cancers but not renal cell carcinoma (RCC). In lines with these efforts, our work demonstrates that mitochondrial translation inhibition by tigecycline or depletion of EF-Tu mitochondrial translation f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.115

    authors： Wang B,Ao J,Yu D,Rao T,Ruan Y,Yao X

    更新日期：2017-08-26 00:00:00

  • Catabolism of intact type VI collagen microfibrils: susceptibility to degradation by serine proteinases.

    abstract：:We present the first direct biochemical evidence for the turnover of intact type VI collagen microfibrils. Matrix-degrading enzymes of the serine proteinase class, including rat mast cell chymases I and II, human mast cell tryptase, neutrophil elastase, cathepsin G and trypsin, were able to catabolize intact type VI c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1349

    authors： Kielty CM,Lees M,Shuttleworth CA,Woolley D

    更新日期：1993-03-31 00:00:00

  • The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes.

    abstract：:Protein kinase C (PKC) fulfills a central role in the decision of cell fate in keratinocytes. Both PKC delta and PKC eta induce growth inhibition and differentiation of normal human keratinocytes (NHK). Here we show that PKC delta and PKC eta play opposite roles in UVB-induced apoptosis in NHK. PKC delta enhanced UVB-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00345-0

    authors： Matsumura M,Tanaka N,Kuroki T,Ichihashi M,Ohba M

    更新日期：2003-03-28 00:00:00

  • Use of photoacoustic Fourier-transform infrared spectroscopy to study phosphates in proteins.

    abstract：:Photoacoustic Fourier-transform infrared spectroscopy was used to study phosphoamino acids and phosphoproteins. Using this method, we have found that the spectral properties of phosphate esters depend on the nature of the linkage, pH, and binding of metal ion. At high pH values, dianionic symmetric stretching of phosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2710

    authors： Graves DJ,Luo S

    更新日期：1994-11-30 00:00:00

  • Endogenous production of nitric oxide by vascular endothelial growth factor down-regulates proliferation of choriocarcinoma cells.

    abstract：:The trophoblast-like choriocarcinoma cell line BeWo expresses a receptor for vascular endothelial growth factor (VEGF) and proliferates in response to VEGF. Nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells but the NO mechanistic regulation of VEGF-stimulated trophoblast...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4682

    authors： Cha MS,Lee MJ,Je GH,Kwak JY

    更新日期：2001-04-13 00:00:00