The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes.

abstract：:MicroRNAs (miRNAs) can negatively regulate gene expression and also induce or inhibit viral replication. In the present study, we found 10 miRNAs were differentially expressed in a stable HBV-producing cell line (HepG2.2.15) compared with its control cell line (HepG2) by miRNA array analysis. miR-501 was significantly...

journal_title：Biochemical and biophysical research communications

authors： Jin J,Tang S,Xia L,Du R,Xie H,Song J,Fan R,Bi Q,Chen Z,Yang G,Liu J,Shi Y,Fan D

更新日期：2013-01-25 00:00:00

abstract：:MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino...

journal_title：Biochemical and biophysical research communications

authors： Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

更新日期：2003-06-13 00:00:00

abstract：:miR-183 cluster, composed of miR-183/-96/-182 genes, is highly expressed in the adult retina, particularly in photoreceptors. It involves in development, maturation and normal function of neuroretina. Ectopic overexpression of miR-183/-96/-182 genes was performed to assess reprogramming of hRPE cells. They were amplif...

journal_title：Biochemical and biophysical research communications

authors： Davari M,Soheili ZS,Samiei S,Sharifi Z,Pirmardan ER

更新日期：2017-01-29 00:00:00

abstract：:Acute stress has been shown to enhance learning and memory ability, predominantly through the action of corticosteroid stress hormones. However, the valuable targets for promoting learning and memory induced by acute stress and the underlying molecular mechanisms remain unclear. Acid-sensing ion channels (ASICs) play ...

journal_title：Biochemical and biophysical research communications

authors： Ye S,Yang R,Xiong Q,Yang Y,Zhou L,Gong Y,Li C,Ding Z,Ye G,Xiong Z

更新日期：2018-04-15 00:00:00

abstract：:The modification of chromatin structure is increasingly recognized to be an important facet of transcriptional regulation. Here, we report that Brahma-related gene 1 (BRG1), a chromatin remodeling enzyme, plays a crucial role in IFN-γ-induced TRIM22 expression. Our results showed that IFN-γ failed to induce TRIM22 exp...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Gao B,Xu W,Xiong S

更新日期：2011-07-08 00:00:00

abstract：:Epidermal growth factor receptor (EGF-R) is a widely expressed ligand-dependent tyrosine kinase. The tyrosine residue at 845 in EGF-R corresponds to Y416 of v/c-src kinase, which is highly conserved and functionally important in many tyrosine kinases. To clarify the functional role of Y845, we constructed a mutant hum...

journal_title：Biochemical and biophysical research communications

authors： Gotoh N,Tojo A,Hino M,Yazaki Y,Shibuya M

更新日期：1992-07-31 00:00:00

abstract：:The two zinc fingers of the DNA binding domain of the human retinoic acid receptor-beta were labelled with 113Cd. Two- and three-dimensional heteronuclear nuclear magnetic resonance (NMR) experiments show that the first eight conserved cysteine residues coordinate the two zinc ions tetrahedrally. The ninth conserved c...

journal_title：Biochemical and biophysical research communications

authors： Knegtel RM,Boelens R,Ganadu ML,George AV,van der Saag PT,Kaptein R

更新日期：1993-04-30 00:00:00

abstract：:Yeast cells adapted to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) exhibit a plasma membrane less susceptible to 2,4-D-induced disruption and are more tolerant than unadapted cells to lethal concentrations of the herbicide. These cells, adapted to grow in the presence of increasing concentrations of 2,4-D, we...

journal_title：Biochemical and biophysical research communications

authors： Viegas CA,Cabral MG,Teixeira MC,Neumann G,Heipieper HJ,Sá-Correia I

更新日期：2005-04-29 00:00:00

abstract：:Hypothalamic neurons monitor peripheral energy status and produce signals to adjust food intake and energy expenditure to maintain homeostasis. However, the molecular mechanisms by which these signals are generated remain unclear. Fluctuations in the level of hypothalamic malonyl-CoA are known to serve as an intermedi...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Wolfgang MJ,Cha SH,Lane MD

更新日期：2007-08-03 00:00:00

abstract：:The intrinsic fluorescence properties of human alpha apohemoglobin at protein concentrations from 1 to 5 microM in 0.1 M potassium phosphate buffer, pH 7 or 8 at 5 degrees C were monitored in the absence and presence of a fixed concentration (5 microM) of a fluorescence quenching heme-containing native or Des (146-His...

journal_title：Biochemical and biophysical research communications

authors： Chiu F,Vasudevan G,Morris A,McDonald MJ

更新日期：1998-01-14 00:00:00

abstract：BACKGROUND/AIMS:Pancreatic islet transplantation is an effective treatment for Type 1 diabetic patients to eliminate insulin injections; however, a shortage of donor organs hinders the widespread use. Although long-term islet storage, such as cryopreservation, is considered one of the key solutions, transplantation of ...

journal_title：Biochemical and biophysical research communications

authors： Komatsu H,Barriga A,Medrano L,Omori K,Kandeel F,Mullen Y

更新日期：2017-05-06 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:We have developed a solid matrix immunoassay to determine the binding of interleukin-2 (IL-2) to specific gangliosides. The assay establishes that recombinant human IL-2 binds to ganglioside GD(1b) but not to any other gangliosides (GM(1), GM(2), GM(3), GD(1a), GD(2), GD(3), and GT(1b)). The binding varies with the ra...

journal_title：Biochemical and biophysical research communications

authors： Ravindranath MH,Gonzales A,Soh D,Nishimoto K,Tam WY,Bilchik A,Morton DL,O'Day S

更新日期：2001-05-04 00:00:00

abstract：:We have selected calcium ionophore (A23187)-resistant cells (AR-7) in a human promyelocytic leukemia cell line, HL-60. AR-7 showed approximately 8.5-fold resistance to A23187 compared with the wild type cells after continuous exposure for 3 days. AR-7 had cross resistance to ionomycin (4.6-fold) and thapsigargin (340-...

journal_title：Biochemical and biophysical research communications

authors： Kubota M,Kataoka A,Okuda A,Bessho R,Lin YW,Wakazono Y,Usami I,Akiyama Y,Furusho K

更新日期：1995-08-15 00:00:00

abstract：:It is widely considered that it is not appropriate to treat beta-pairs in isolation, since other secondary structural models (such as helices, coils), protein topology and protein tertiary structures would limit beta-strand pairing. However, to understand the underlying mechanisms of beta-sheet formation, studies ough...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Ruan J,Duan G,Gao S,Zhang T

更新日期：2009-08-28 00:00:00

abstract：:Native LDL would be a mitogenic and chemotactic stimulus of VSMC proliferation and differentiation in the atherosclerotic lesion where endothelial disruption occurred. In previous studies, our group investigated the molecular mechanisms by which LDL induces IL-8 production and by which PPARalpha activation abolishes L...

journal_title：Biochemical and biophysical research communications

authors： Heo KS,Kim DU,Ryoo S,Nam M,Baek ST,Kim L,Park SK,Myung CS,Hoe KL

更新日期：2007-08-10 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that regulate target gene expression through translation repression or messenger RNA degradation. MiR-15a and 16-1 form a cluster at the chromosomal region 13q14, which is frequently deleted or down-regulated in chronic lymphocytic leukemia. Arsenic trioxide (As(2)O(3), ATO)...

journal_title：Biochemical and biophysical research communications

authors： Gao SM,Chen C,Wu J,Tan Y,Yu K,Xing CY,Ye A,Yin L,Jiang L

更新日期：2010-12-10 00:00:00

abstract：:By performing immunofluorescence staining assays in confluent COS-7 cells, hepatitis B virus core, small surface and large surface proteins were found to localize largely in the nucleus, diffusely in the cytoplasm, and accumulatively in a perinuclear area, respectively. When two proteins were co-expressed, the core pr...

journal_title：Biochemical and biophysical research communications

authors： Yeh CT,Ou JH,Chu CM,Liaw YF

更新日期：1994-09-15 00:00:00

abstract：:EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investiga...

journal_title：Biochemical and biophysical research communications

authors： Bernsteiner H,Bründl M,Stary-Weinzinger A

更新日期：2017-02-26 00:00:00

abstract：:The I domains of CD11 are responsible for the binding of ligands and have a unique structure with 6-7 alpha helices and 6 beta sheets with interconnecting loops. To determine loops recognizing fibrinogen in CD11c I domain, five oligopeptides corresponding to CD11c loops were used to prevent fibrinogen binding to isola...

journal_title：Biochemical and biophysical research communications

authors： Choi J,Nham SU

更新日期：2002-04-05 00:00:00

abstract：:Recent studies have demonstrated homology between bone-derived growth factor and beta 2 microglobulin. We have shown that beta 2 microglobulin has proliferative actions on human bone-derived cells in vitro and that these cells also show immunogenicity for beta 2 microglobulin. beta 2 microglobulin stimulated the incor...

journal_title：Biochemical and biophysical research communications

authors： Evans DB,Thavarajah M,Kanis JA

更新日期：1991-03-29 00:00:00

abstract：:Mycobacterium smegmatis is a good model for studying the physiology and pathogenesis of Mycobacterium tuberculosis due to its genetic similarity. As methionine biosynthesis exists only in microorganisms, the enzymes involved in methionine biosynthesis can be a potential target for novel antibiotics. Homoserine O-acety...

journal_title：Biochemical and biophysical research communications

authors： Sagong HY,Hong J,Kim KJ

更新日期：2019-09-24 00:00:00

abstract：:The recognition and removal of interstrand cross-links is perhaps the least understood of all repair pathways in eukaryotic cells. We have shown previously that uncoupling of cross-links occurs in mammalian cell extracts and have identified a number of factors that mediate this process. However, we have not observed c...

journal_title：Biochemical and biophysical research communications

authors： Lu X,Zhang N,Vasquez K,Barton M,Legerski R

更新日期：2005-10-14 00:00:00

abstract：:To help clarify bases for the molecular weight and surface charge heterogeneities of forms of somatic angiotensin converting enzyme (ACE), we examined for differences in N-glycosylation. ACE preparations purified from human, guinea pig, rat and rabbit tissues were found to be heterogeneous in terms of numbers of N-gly...

journal_title：Biochemical and biophysical research communications

authors： Ripka JE,Ryan JW,Valido FA,Chung AY,Peterson CM,Urry RL

更新日期：1993-10-29 00:00:00

abstract：:High level of palmitate is associated with metabolic disorders. We recently showed that enhanced level of S-palmitoylated cytosolic thioredoxin (Trx1) in mouse liver was new characteristic feature of insulin resistance. However, our understanding of the effect of S-palmitoylation on Trx1 is limited, and the tissue spe...

journal_title：Biochemical and biophysical research communications

authors： Xu Z,Zhong L

更新日期：2015-05-15 00:00:00

abstract：:AMP, an allosteric inhibitor at neutral pH, activates snakes muscle fructose 1,6-bisphosphatase at pH 9.2. The activation is virtually unique for the snake muscle enzyme: activation was not observed for the enzymes from either human and rabbit liver or porcine kidney. The activation is Mg(2+)-dependent but was not obs...

journal_title：Biochemical and biophysical research communications

authors： Zhao FK,Xu SQ,Xu GJ

更新日期：1998-03-27 00:00:00

abstract：:More than 80% of tumors that occur in the brain are malignant gliomas. The prognosis of glioma patients is still poor, which makes glioma an urgent subject of cancer research. Previous evidence and our present data show that PCBP2 is over-expressed in human glioma tissues and predicts poor outcome. However, the mechan...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Hao B,Liu Y,Dai D,Han G,Li Y,Wu X,Zhou X,Yue Z,Wang L,Cao Y,Liu J

更新日期：2014-03-28 00:00:00

abstract：:Identifying Mycobacterium tuberculosis membrane proteins involved in binding to and invasion of host cells is important in designing subunit-based anti-tuberculosis vaccines. The Rv2969c gene sequence was identified by PCR in M. tuberculosis complex strains, being transcribed in M. tuberculosis H37Rv, M. tuberculosis ...

journal_title：Biochemical and biophysical research communications

authors： Patarroyo MA,Plaza DF,Ocampo M,Curtidor H,Forero M,Rodriguez LE,Patarroyo ME

更新日期：2008-08-08 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:Covalently bound fatty acids were found in strictly purified and delipidated gastric mucus glycoprotein of normal and cystic fibrosis individuals. The susceptibility of this linkage to methanolic KOH and hydroxylamine treatment indicated the ester bond between fatty acids and glycoprotein. On the average, 2.9 nmol fat...

journal_title：Biochemical and biophysical research communications

authors： Slomiany A,Slomiany BL,Witas H,Aono M,Newman LJ

更新日期：1983-05-31 00:00:00