当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Localization and effect of ectopic expression of CPT1c in CNS feeding centers.

Localization and effect of ectopic expression of CPT1c in CNS feeding centers.

Abstract：

:Hypothalamic neurons monitor peripheral energy status and produce signals to adjust food intake and energy expenditure to maintain homeostasis. However, the molecular mechanisms by which these signals are generated remain unclear. Fluctuations in the level of hypothalamic malonyl-CoA are known to serve as an intermediary in regulating energy homeostasis and it has been proposed that the brain-specific carnitine palmitoyltransferase-1c (CPT1c) serves as a target of malonyl-CoA in the central nervous system (CNS). Here, we report that CPT1c is widely expressed in neurons throughout the CNS including the hypothalamus, hippocampus, cortex, and amygdala. CPT1c is enriched in neural feeding centers of the hypothalamus with mitochondrial localization as an outer integral membrane protein. Ectopic over-expression of CPT1c by stereotactic hypothalamic injection of a CPT1c adenoviral vector is sufficient to protect mice from body weight gain when fed a high-fat diet. These findings show that CPT1c is appropriately localized in regions and cell types to regulate energy homeostasis and that its over-expression in the hypothalamus is sufficient to protect mice from adverse weight gain caused by high-fat intake.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Dai Y,Wolfgang MJ,Cha SH,Lane MD

doi

10.1016/j.bbrc.2007.05.161

subject

Has Abstract

pub_date

2007-08-03 00:00:00

pages

469-74

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01080-7

journal_volume

359

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • AMP-activated protein kinase is essential for survival in chronic hypoxia.

    abstract：:This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.056

    authors： Borger DR,Gavrilescu LC,Bucur MC,Ivan M,Decaprio JA

    更新日期：2008-05-30 00:00:00

  • ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor.

    abstract：:p105 plays dual roles in NF-kappaB signaling: in its precursor form it inhibits NF-kappaB activation, but limited processing by the ubiquitin system generates the p50 active subunit of the transcription factor. Here we show that ABIN-1, an A20-binding protein that is also known to attenuate NF-kappaB activation, inhib...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.074

    authors： Cohen S,Ciechanover A,Kravtsova-Ivantsiv Y,Lapid D,Lahav-Baratz S

    更新日期：2009-11-13 00:00:00

  • Identification of activators of methionine sulfoxide reductases A and B.

    abstract：:The methionine sulfoxide reductase (Msr) family of enzymes has been shown to protect cells against oxidative damage. The two major Msr enzymes, MsrA and MsrB, can repair oxidative damage to proteins due to reactive oxygen species, by reducing the methionine sulfoxide in proteins back to methionine. A role of MsrA in a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.12.077

    authors： Cudic P,Joshi N,Sagher D,Williams BT,Stawikowski MJ,Weissbach H

    更新日期：2016-01-22 00:00:00

  • GPR35 is a functional receptor in rat dorsal root ganglion neurons.

    abstract：:GPR35, previously an orphan G-protein coupled receptor, is a receptor for kynurenic acid. Here we examine the distribution of GPR35 in the rat dorsal root ganglion (DRG) and the effects of its selective activation. GPR35 was expressed predominantly by small- to medium-diameter neurons of the DRG. Many of these same ne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.197

    authors： Ohshiro H,Tonai-Kachi H,Ichikawa K

    更新日期：2008-01-11 00:00:00

  • Synthesis of a nonreducible cyclic analog of somatostatin having only growth hormone release inhibiting activity.

    abstract：:A nonreducible cyclic analog of somatostatin (SRIF) was prepared by a combination of solid phase and solution peptide synthesis. The compound, gamma-Abu-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Asp-OH, was tested for its effect on the release of growth hormone, glucagon and insulin in rats. It significantly suppressed ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(76)90208-4

    authors： Garsky VM,Clark DE,Grant NH

    更新日期：1976-12-20 00:00:00

  • Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells.

    abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90926-4

    authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

    更新日期：1984-10-15 00:00:00

  • Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

    abstract：:Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/β-catenin pathway is crucial in maintaining the stemness of CSCs. (-)-Epigallocatechin-3-gallate (EGCG), the major bioactive component in green tea, has been shown to possess anti-cancer activity. To date, the interventional effect of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.038

    authors： Zhu J,Jiang Y,Yang X,Wang S,Xie C,Li X,Li Y,Chen Y,Wang X,Meng Y,Zhu M,Wu R,Huang C,Ma X,Geng S,Wu J,Zhong C

    更新日期：2017-01-01 00:00:00

  • Effects of endothelin-1 on K(+) currents from rat ventricular myocytes.

    abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5083

    authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

    更新日期：2001-06-22 00:00:00

  • Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine.

    abstract：:Many cell types are known to synthesize nitric oxide (NO.) from L-arginine. There appear to be at least two forms of NO. synthase: an inducible, tetrahydrobiopterin- and flavin-dependent activity exemplified by the macrophage enzyme and a constitutive, Ca+(+)-dependent activity exemplified by the endothelial cell enzy...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91245-n

    authors： Gross SS,Stuehr DJ,Aisaka K,Jaffe EA,Levi R,Griffith OW

    更新日期：1990-07-16 00:00:00

  • Phosphoinositide phosphorylation precedes growth in rat mammary tumors.

    abstract：:DMBA-induced rat mammary tumors were used to study the possible association of phosphoinositide phosphorylation to tumor growth. These membranous enzymatic activities were measured during various stages of tumor growth induced by pharmacological manipulation of plasma prolactin level. An increase in phosphorylation of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80501-0

    authors： Sharoni Y,Teuerstein I,Levy J

    更新日期：1986-01-29 00:00:00

  • A novel insertion of a rearranged L1 element in exon 44 of the dystrophin gene: further evidence for possible bias in retroposon integration.

    abstract：:L1 elements are mammalian retrotransposons contributing to genome evolution and causing rare mutations in human. We describe a de novo insertion of an L1 element into the dystrophin gene resulting in skipping of exon 44 and causing Duchenne muscular dystrophy in a boy. The L1 element was rearranged due to the twin-pri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.071

    authors： Musova Z,Hedvicakova P,Mohrmann M,Tesarova M,Krepelova A,Zeman J,Sedlacek Z

    更新日期：2006-08-18 00:00:00

  • Polyamines are sufficient to drive the transport of the precursor of ornithine carbamoyltransferase into rat liver mitochondria: possible effect on mitochondrial membranes.

    abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80210-4

    authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

    更新日期：1989-01-16 00:00:00

  • Photofrin as a radiosensitizer in an in vitro cell survival assay.

    abstract：:Chemical modifiers (radiosensitizers) are used in order to increase the efficacy of radiotherapy. The use of Photodynamic Therapy for tumor treatment, especially with Photofrin II, is also known. At present, no chemical modifier has been found to act as a selective radiosensitizer. Experiments using several series of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.09.170

    authors： Kulka U,Schaffer M,Siefert A,Schaffer PM,Olsner A,Kasseb K,Hofstetter A,Dühmke E,Jori G

    更新日期：2003-11-07 00:00:00

  • Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.

    abstract：:For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91438-x

    authors： De Clercq E,Cools M

    更新日期：1985-05-31 00:00:00

  • Mast cell chemotactic activity of RANTES.

    abstract：:RANTES is a cytokine produced by activated T-lymphocytes that has been shown to exert chemotactic activity for memory-type CD4 T-lymphocytes and eosinophils. In this study, RANTES caused directional migration of human mast cells. When compared to other potential chemoattractants of the same cells, RANTES was found to ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1505

    authors： Mattoli S,Ackerman V,Vittori E,Marini M

    更新日期：1995-04-06 00:00:00

  • Promoter analysis and chromosomal mapping of human EBAG9 gene.

    abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2920

    authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

    更新日期：2000-07-05 00:00:00

  • INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.

    abstract：:Docetaxel efficiency in the therapy of prostate cancer (PCa) patients is limited due to the development of chemoresistance. Recent studies have implied a role of INPP4B in tumor chemoresistance, while the effects of INPP4B on docetaxel resistance in PCa have not been elucidated. In the present study, the docetaxel-res...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.073

    authors： Chen H,Li H,Chen Q

    更新日期：2016-08-26 00:00:00

  • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

    abstract：:Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.07.147

    authors： Muñoz JP,Collao A,Chiong M,Maldonado C,Adasme T,Carrasco L,Ocaranza P,Bravo R,Gonzalez L,Díaz-Araya G,Hidalgo C,Lavandero S

    更新日期：2009-10-09 00:00:00

  • Characterization of the mouse Myoc/Tigr gene.

    abstract：:Mutations in the myocilin (MYOC), also known as Trabecular meshwork-Inducible Glucocorticoid Response (TIGR) gene can lead to juvenile open-angle glaucoma in human and may be responsible for at least 3% of primary open-angle glaucoma. To develop a mouse model of primary open angle glaucoma, and to get deeper insight i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8541

    authors： Tomarev SI,Tamm ER,Chang B

    更新日期：1998-04-28 00:00:00

  • The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation.

    abstract：:REV-ERBα is a nuclear heme receptor, transcriptional repressor and critical component of the molecular clock that drives daily rhythms of metabolism. Evidence reveals that REV-ERBα also plays an important regulatory role in clock-dependent lung physiology and inflammatory responses. We hypothesize that cigarette smoke...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.09.157

    authors： Sundar IK,Rashid K,Sellix MT,Rahman I

    更新日期：2017-12-02 00:00:00

  • Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice.

    abstract：:The Cardiac sodium channel gene SCN5A plays a critical role in cardiac electrophysiology and its mutations, either gain- or loss-of-functions, are associated with lethal arrhythmias. In this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype in a transgenic mouse model (TG-WT L10). C...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.170

    authors： Zhang T,Yong SL,Tian XL,Wang QK

    更新日期：2007-04-06 00:00:00

  • Using a ubiquitin ligase as an unfolded protein sensor.

    abstract：:A significant fraction of all proteins are misfolded and must be degraded. The ubiquitin-proteasome pathway provides an essential protein quality control function necessary for normal cellular homeostasis. Substrate specificity is mediated by proteins called ubiquitin ligases. In the endoplasmic reticulum (ER) a speci...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.12.109

    authors： Mallinger A,Wen HM,Dankle GM,Glenn KA

    更新日期：2012-02-03 00:00:00

  • Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation.

    abstract：:The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro kinase assay demonstrated that it is a substrate for MAP kinase. Phosphorylation of endogenous HABP1 was also observed following treatment of J774 cells with PMA. HABP1 was coimmunoprecipitated with activated ERK, confirmi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6491

    authors： Majumdar M,Meenakshi J,Goswami SK,Datta K

    更新日期：2002-03-08 00:00:00

  • MiR-181a contributes gefitinib resistance in non-small cell lung cancer cells by targeting GAS7.

    abstract：:Tyrosine kinase inhibitors (TKIs) exert potent therapeutic efficacy in non-small cell lung cancers (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations. However, a major impediment for the effective treatment is the development of drug resistance. Some evidence supports a role for miRNAs in m...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.096

    authors： Ping W,Gao Y,Fan X,Li W,Deng Y,Fu X

    更新日期：2018-01-22 00:00:00

  • SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint.

    abstract：:We have shown previously that SNM1A colocalizes with 53BP1 at sites of double-strand breaks (DSBs) induced by IR, and that these proteins interact with or without DNA damage. However, the role of SNM1A in the DNA damage response has not been elucidated. Here, we show that SNM1A is required for an efficient G1 checkpoi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.130

    authors： Akhter S,Legerski RJ

    更新日期：2008-12-05 00:00:00

  • Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF.

    abstract：:Expression of brain-derived neurotrophic factor (BDNF) mRNA is increased in the dorsal root ganglion (DRG) in response to peripheral inflammation. Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF. Recently, it was reported that the BDNF gene has eight non-coding exons that are...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.022

    authors： Matsuoka Y,Yokoyama M,Kobayashi H,Omori M,Itano Y,Morita K,Mori H,Nakanishi T

    更新日期：2007-10-26 00:00:00

  • Location and methylation pattern of a nuclear matrix associated region in the human pro alpha 2(I) collagen gene.

    abstract：:Using both a 25 mM Lithium di-iodosalicylic acid (LIS) and a 2M NaCl extraction procedure to extract nuclear matrices from white cells we have identified a 0.9 kb nuclear matrix associated region (MAR) in the human pro alpha 2(I) collagen gene. The MAR is located towards the 3' coding end of the gene, it is completely...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80277-8

    authors： Ellis GC,Grobler-Rabie AF,Hough FS,Bester AJ

    更新日期：1988-12-15 00:00:00

  • Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite.

    abstract：:Oxidative stress induced by arsenite [As(III)] affects protein folding and results in increased levels of misfolded proteins or protein aggregates. Accumulation of misfolded protein aggregates may act as a cue signal for the oligomerization of the autophagic adaptor protein p62, which facilitates recognition of misfol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.03.146

    authors： Lee H,Kim MN,Ryu KY

    更新日期：2017-05-06 00:00:00

  • Identification of a lysophosphatidylserine receptor on mast cells.

    abstract：:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orpha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.01.069

    authors： Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

    更新日期：2006-03-24 00:00:00

  • Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.

    abstract：:Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S pha...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.056

    authors： Kim BJ,Kang KM,Jung SY,Choi HK,Seo JH,Chae JH,Cho EJ,Youn HD,Qin J,Kim ST

    更新日期：2008-07-25 00:00:00