Esco2 is a novel corepressor that associates with various chromatin modifying enzymes.

abstract：:Transcriptional mechanisms controlling human UCP3 gene expression in skeletal muscle remain poorly understood. Experiments based on plasmid electrotransfer into tibialis anterior muscle of C57/BL6 male mice were set up in order to functionally analyze the hUCP3 gene promoter. These transfection experiments showed that...

journal_title：Biochemical and biophysical research communications

authors： Riquet FB,Rodriguez M,Guigal N,Dromaint S,Naime I,Boutin JA,Galizzi JP

更新日期：2003-11-21 00:00:00

abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

journal_title：Biochemical and biophysical research communications

authors： Mulder E,Vrij AA,Brinkmann AO

更新日期：1983-08-12 00:00:00

abstract：:Neonatal hypoxia can induce the persisting brain dysfunctions and subsequently result in the behavioral abnormalities in adulthood. Improving mitochondrial functions were suggested as the effective strategy for brain functional recovery. In this study, we tested the effects of physical exercise, a well-established way...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Ye R,Liang R,Xing F

更新日期：2020-03-05 00:00:00

abstract：:Angiogenin is a potent angiogenic factor secreted by cultured tumor cells and is found in various normal organs and tissues. The ovary is one of the adult organs in which angiogenesis normally occurs during the female reproductive cycle. In this study, we examined whether angiogenin protein is localized and if angioge...

journal_title：Biochemical and biophysical research communications

authors： Lee HS,Lee IS,Kang TC,Jeong GB,Chang SI

更新日期：1999-04-02 00:00:00

abstract：:The thioredoxin system is a key cellular antioxidant system and is highly expressed in cancer cells, especially in more aggressive and therapeutic resistant tumors. We analysed the expression of the thioredoxin system in the MDA-MB-231 breast cancer cell line under conditions mimicking the tumor oxygen microenvironmen...

journal_title：Biochemical and biophysical research communications

authors： Karlenius TC,Shah F,Di Trapani G,Clarke FM,Tonissen KF

更新日期：2012-03-09 00:00:00

abstract：:Although mammary epithelial cells are known to synthesize and accumulate triacylglycerol (TAG) in order to produce milk lipid in the cytosol, lipid and energy metabolism is still not fully understood. In this study, we assessed the effects of long-chain fatty acid (LCFA) on the accumulation of cytosolic TAG and uncoup...

journal_title：Biochemical and biophysical research communications

authors： Yonezawa T,Sanosaka M,Haga S,Kobayashi Y,Katoh K,Obara Y

更新日期：2008-10-17 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:Effects of growth hormone on morphology and cytoskeletal protein expression were examined in 3T3-F442A preadipocytes in serum-free medium. Between 2 and 5 days of culture 2 nM methionyl human growth hormone converted 3T3-F442A cells from a flat fibroblastic morphology to a rounded form with numerous membrane convoluti...

journal_title：Biochemical and biophysical research communications

authors： Guller S,Corin RE,Wu KY,Sonenberg M

更新日期：1989-09-15 00:00:00

abstract：:Severe cold exposure and pressure overload are both known to prompt oxidative stress and pathological alterations in the heart although the interplay between the two remains elusive. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and en...

journal_title：Biochemical and biophysical research communications

authors： Lu S,Xu D

更新日期：2013-12-06 00:00:00

abstract：:Serine proteinase inhibitors are widely distributed in nature and inhibit the activity of enzymes like trypsin and chymotrypsin. These proteins interfere with the physiological processes such as germination, maturation and form the first line of defense against the attack of seed predator. The most thoroughly examined...

journal_title：Biochemical and biophysical research communications

authors： Sattar R,Ali SA,Kamal M,Khan AA,Abbasi A

更新日期：2004-02-13 00:00:00

abstract：:UCP-2 is a member of the emerging family of UCP homologues. Upon high-fat feeding, UCP-2 mRNA levels are increased in epididymal fat pads of A/J mice, suggesting that the flux of fatty acids entering adipose tissue may regulate UCP-2 gene expression. Since fatty acids act as positive transcriptional regulators of lipi...

journal_title：Biochemical and biophysical research communications

authors： Aubert J,Champigny O,Saint-Marc P,Negrel R,Collins S,Ricquier D,Ailhaud G

更新日期：1997-09-18 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:A novel nuclear magnetic resonance (NMR) spectroscopy probe was designed and constructed for the study of transient metabolic changes in cellular systems during exposure to ionizing radiation. The probe incorporated a bioreactor, a radiation source, and a radiofrequency detection circuit tunable between 100 and 300 MH...

journal_title：Biochemical and biophysical research communications

authors： Magness JE,McFarland EW

更新日期：1997-04-07 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a major cause of heart failure in younger individuals. Its prognosis is poor with 40-50% of patients dying within 2 years after diagnosis. Although the etiology of DCM is poorly understood, there is increasing evidence that DCM may represent an autoimmune disease in a significant subset...

journal_title：Biochemical and biophysical research communications

authors： Nickenig G,Wolff M,Stäblein A,Pfister H,Böhm M

更新日期：1999-12-20 00:00:00

abstract：:Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal anti-inflammatory drugs. A functional polymorphism of the CYP2C9 gene has been described. The variant alleles include CYP2C9*2 having a point mutation in exon 3 ca...

journal_title：Biochemical and biophysical research communications

authors： Yasar U,Eliasson E,Dahl ML,Johansson I,Ingelman-Sundberg M,Sjöqvist F

更新日期：1999-01-27 00:00:00

abstract：:MDP, a synthetic muramyl dipeptide, is capable of increasing the primary in vitro antibody response, to sheep erythrocytes, of purified B cells restored with a monokine and helper T cell factors, including Interleukin 2 and the late-acting T cell replacing factor (TRF). First, the possibility that the adjuvanticity of...

journal_title：Biochemical and biophysical research communications

authors： Souvannavong V,Adam A

更新日期：1984-11-30 00:00:00

abstract：:The origins and developmental regulation of cerebellar oligodendrocytes are largely unknown, although some hypotheses of embryonic origins have been suggested. Neural stem cells exist in the white matter of postnatal cerebellum, but it is unclear whether these neural stem cells generate oligodendrocytes at postnatal s...

journal_title：Biochemical and biophysical research communications

authors： Naruse M,Shibasaki K,Ishizaki Y

更新日期：2015-08-07 00:00:00

abstract：:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant...

journal_title：Biochemical and biophysical research communications

authors： Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

更新日期：1984-10-15 00:00:00

abstract：:Epithelial cells form a globular organ-like multi-cellular structure called cyst when cultured in extracellular matrix. The cyst generates extension followed by cell chains and tubules in response to hepatocyte growth factor (HGF). The Rho family small GTPases play essential roles for tubulogenesis. FilGAP, a Rac spec...

journal_title：Biochemical and biophysical research communications

authors： Zuinen T,Tsutsumi K,Ohta Y

更新日期：2019-06-30 00:00:00

abstract：:During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylger...

journal_title：Biochemical and biophysical research communications

authors： Bruscalupi G,Castellano F,Sacco S,Trentalance A

更新日期：1994-05-16 00:00:00

abstract：:Expression of brain-derived neurotrophic factor (BDNF) mRNA is increased in the dorsal root ganglion (DRG) in response to peripheral inflammation. Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF. Recently, it was reported that the BDNF gene has eight non-coding exons that are...

journal_title：Biochemical and biophysical research communications

authors： Matsuoka Y,Yokoyama M,Kobayashi H,Omori M,Itano Y,Morita K,Mori H,Nakanishi T

更新日期：2007-10-26 00:00:00

abstract：:Pathogen-triggered generation of reactive oxidants, termed the oxidative burst, contributes to disease resistance in both plant and animal kingdoms. Since phospholipase D plays a key role in the neutrophil oxidative burst signaling cascade and is highly abundant in plants, we investigated its participation in the plan...

journal_title：Biochemical and biophysical research communications

authors： Schroeder Taylor AT,Low PS

更新日期：1997-08-08 00:00:00

abstract：:We have previously provided evidence for a mechanism by which acyl DHAP is converted enzymatically to O-alkyl DHAP. This mechanism involves, in part, the formation of an endiol of acyl DHAP, loss of the fatty acid by splitting of the DHAP carbon-1 to oxygen bond and the gain of a long chain fatty alcohol. It has been ...

journal_title：Biochemical and biophysical research communications

authors： Friedberg SJ,Weintraub ST,Peterson D,Satsangi N

更新日期：1987-06-30 00:00:00

abstract：:Four analogues of parathyroid hormone-related protein (PTHrP), PTHrP(7-34)NH2, (10-34)NH2, (15-34)NH2 and (20-34)NH2, were synthesized and their antagonistic activity against PTHrP(1-34) was examined in vitro and in vivo. In vitro studies revealed that all four analogues antagonized PTHrP-stimulated cyclic AMP product...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki K,Yamaguchi K,Miyake Y,Hayashi C,Honda S,Urakami K,Miki K,Kimura S,Watanabe T,Abe K

更新日期：1989-02-15 00:00:00

abstract：:The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secreta...

journal_title：Biochemical and biophysical research communications

authors： Meyer-Alber A,Fetz I,Waschulewski IH,Höcker M,Fölsch UR,Schmidt WE

更新日期：1994-06-30 00:00:00

abstract：:Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells adapt to hyposmotic stress including that of regulatory volume decrease. In ischemia and reperfus...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Elizondo J,Chiong M,Rojas-Rivera D,Olea-Azar C,Kwon HM,Lavandero S

更新日期：2006-12-01 00:00:00

abstract：:While mutation of alpha-synuclein is a cause of autosomal-dominant Parkinson's disease (PD), it is still elusive as to how alpha-synuclein is involved in the pathogenesis of PD. Here, we show that dopamine-dependent accumulation of alpha-synuclein in cultured cells results in apoptosis. Furthermore, activation of insu...

journal_title：Biochemical and biophysical research communications

authors： Kao SY

更新日期：2009-07-31 00:00:00

abstract：:Dysfunction of Girdin plays a crucial role in the development of a variety of tumors. Phosphorylated regulation of Girdin has been studied extensively. However, how Girdin is dephosphorylated remains unclear. In this study, we report a mechanism of Girdin dephosphorylation and the importance of this mechanism in the m...

journal_title：Biochemical and biophysical research communications

authors： Li J,Enomoto A,Weng L,Sun L,Takahashi M

更新日期：2019-05-21 00:00:00

abstract：:A soluble factor, extracted from neutrophils and P388D1 cells, stimulated a transient rise in cytosolic free Ca2+ and a small increase in the permeability to Mn2+ in fura2-loaded neutrophils. These effects were not prevented by blockade of formylated peptide receptors by t-boc-met-leu-phe. The rise in cytosolic free C...

journal_title：Biochemical and biophysical research communications

authors： Davies EV,Hallett MB

更新日期：1995-01-05 00:00:00

abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

journal_title：Biochemical and biophysical research communications

authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

更新日期：2012-09-07 00:00:00