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Synthesis of a nonreducible cyclic analog of somatostatin having only growth hormone release inhibiting activity.

Abstract：

:A nonreducible cyclic analog of somatostatin (SRIF) was prepared by a combination of solid phase and solution peptide synthesis. The compound, gamma-Abu-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Asp-OH, was tested for its effect on the release of growth hormone, glucagon and insulin in rats. It significantly suppressed pentobarbital-stimulated growth hormone release but showed no effect on arginine-stimulated glucagon or insulin release. The linear form, NH2-gamma-Abu-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Asp-OH, was also prepared and tested in vivo. It was shown to have only slight activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Garsky VM,Clark DE,Grant NH

doi

10.1016/0006-291x(76)90208-4

subject

Has Abstract

pub_date

1976-12-20 00:00:00

pages

911-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

0006-291X(76)90208-4

journal_volume

73

pub_type

杂志文章

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