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Dual effect of insulin on in vitro leptin secretion by adipose tissue.

Abstract：

:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (from 1 to 25 mM), the stimulatory phase required the presence of physiological or supraphysiological glucose concentrations. In fact, leptin secretion was virtually eliminated in the presence of glucose uptake inhibitors. This dual effect of insulin was not due to modifications of the ob mRNA levels, suggesting that it depends entirely on posttranslational mechanisms. In conclusion, insulin appears to induce an early inhibition of leptin secretion by the adipose cell, followed later by a stimulatory effect secondary to the metabolic changes triggered by the insulin-induced increase in glucose uptake.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

doi

10.1006/bbrc.2000.3506

subject

Has Abstract

pub_date

2000-09-24 00:00:00

pages

477-82

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93506-X

journal_volume

276

pub_type

杂志文章

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