Abstract:
:A rat transplantable pituitary tumor, MtT/F84, grows much faster in E2 treated rats than in normal females, but is much retarded in thyroidectomized rats. Triiodothyronine (T3) administration in a drinking water increased the tumor growth by the dose dependent manner. The tumor contained both estrogen receptor (ER) and T3 receptor. ER levels both in the nuclei and cytosols elevated 2 to 3 times by the T3 administration compared to those of control. E2 administration promotes the growth of MtT/F84 through elevation of nuclear ER level. T3 may directly elevate cellular ER level and thus it may enhance estrogenic actions including the tumor growth.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Fujimoto N,Roy B,Watanabe H,Ito Adoi
10.1016/s0006-291x(88)80677-6subject
Has Abstractpub_date
1988-04-15 00:00:00pages
44-8issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(88)80677-6journal_volume
152pub_type
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