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Insulin-dependent phosphatidylinositol 3'-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells.

Abstract：

:In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activated insulin receptor as revealed by immunoblotting. Whereas insulin receptor substrate-1 was weakly detected, insulin increased 5.5 +/- 1.5-fold (mean +/- SD) PtdIns 3'-kinase activity in receptor immunoprecipitates. We conclude that insulin-stimulated PtdIns 3'-kinase activity is measurable in circulating mononuclear cells which may constitute an easily available cellular model for the detection of post-receptor defects in insulin-resistant states.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Renard E,Grigorescu F,Lavabre C,Kahn CR

doi

10.1006/bbrc.1995.1494

subject

Has Abstract

pub_date

1995-04-06 00:00:00

pages

234-41

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71494-5

journal_volume

209

pub_type

杂志文章

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