Human ribosomal protein L7 carries two nucleic acid-binding domains with distinct specificities.

abstract：:Microarray technology provides a powerful approach to understand complex biological systems. The most common application of microarray technology is to document gene expression profiles of all genes within a genome in response to specific conditions such as disease, drug application, or genotype. One result of this te...

journal_title：Biochemical and biophysical research communications

authors： Díaz E

更新日期：2009-07-24 00:00:00

abstract：:Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular di...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Kitaichi N,Wu D,Hase K,Satoh M,Iwata D,Namba K,Kanda A,Noda K,Itai A,Iwabuchi K,Ishida S

更新日期：2020-05-07 00:00:00

abstract：:In the present study, we demonstrated that Ang II provokes a transitory enhancement of focal adhesion kinase (FAK) and paxillin phosphorylation in human umbilical endothelial cells (HUVEC). Moreover, Ang II induces a time- and dose-dependent augmentation in cell migration, but does not affect HUVEC proliferation. The ...

journal_title：Biochemical and biophysical research communications

authors： Montiel M,de la Blanca EP,Jiménez E

更新日期：2005-02-25 00:00:00

abstract：:The intrinsic GTPase activity of cellular protein p21ras is strongly increased by cytosolic GTPase activating protein (GAP). The activity of this enzyme has been shown to be inhibited by arachidonic acid. We report here that this inhibition is antagonized by the presence of 1-stearoyl, 2-arachidonoyl glycerol. This ef...

journal_title：Biochemical and biophysical research communications

authors： Homayoun P,Stacey DW

更新日期：1993-08-16 00:00:00

abstract：:The production of hydroxyl radicals by tetrachlorohydroquinone (TCHQ, a major metabolite of the widely used biocide pentachlorophenol) in the presence of H(2)O(2) was studied by salicylate hydroxylation method. HPLC with electrochemical detection was used to measure the levels of 2,3- and 2,5-dihydroxybenzoic acid (DH...

journal_title：Biochemical and biophysical research communications

authors： Zhu BZ,Kitrossky N,Chevion M

更新日期：2000-04-21 00:00:00

abstract：:Osteoclast activity is enhanced in acidic environments following systemic or local inflammation. However, the regulatory mechanism of receptor activator of NF-κB ligand (RANKL) expression in osteoblasts under acidic conditions is not fully understood. In the present paper, we detected the mRNA expression of the G-prot...

journal_title：Biochemical and biophysical research communications

authors： Okito A,Nakahama K,Akiyama M,Ono T,Morita I

更新日期：2015-03-06 00:00:00

abstract：:A novel cDNA clone was identified through yeast two-hybrid experiments. Following cross-examination between the cDNA clones, EST clones, and the cosmid clone, we could digitally assemble a new zinc finger transcription factor gene. This predicted gene has a cDNA size of about 1960 bp and is translated into a 487-amino...

journal_title：Biochemical and biophysical research communications

authors： Lin W,Lai CH,Tang CJ,Huang CJ,Tang TK

更新日期：1999-11-02 00:00:00

abstract：:Cells of the sponge Microciona prolifera dissociated in Ca,Mg-free sea water reaggregate upon addition of Ca, an observation classically attributed to the requirement for Ca of a species-specific aggregation factor. We now report that, unexpectedly, extracellular Ca is not required during aggregation; brief Ca pulses ...

journal_title：Biochemical and biophysical research communications

authors： Dunham P,Weissmann G

更新日期：1986-02-13 00:00:00

abstract：:Release of soluble growth hormone binding protein (GHBP) corresponding to the extracellular domain of the GH receptor (GHR) occurs via distinct mechanisms depending on species. In human, proteolysis of full length GHR results in liberation of GHBP into the extracellular medium. A putative protease responsive for GHR c...

journal_title：Biochemical and biophysical research communications

authors： Conte F,Salles JP,Raynal P,Fernandez L,Molinas C,Tauber M,Bieth E

更新日期：2002-01-18 00:00:00

abstract：:Ribosomal proteins must be imported into the nucleus after being synthesized in the cytoplasm. Since the rpS2 amino acid sequence does not contain a typical nuclear localization signal, we used deletion mutant analysis and rpS2-beta-galactosidase chimeric proteins to identify the nuclear targeting domains in rpS2. Nuc...

journal_title：Biochemical and biophysical research communications

authors： Antoine M,Reimers K,Wirz W,Gressner AM,Müller R,Kiefer P

更新日期：2005-09-16 00:00:00

abstract：:Protein markers induced by hormones are the necessary probes to study hormone regulation of gene expression. We have previously shown that ACTH was able to induce one of these markers in the cytosol of the rat adrenal: protein E (Dazord et al, Biochem. J., 176, 233-239, 1978). In this paper by using adrenal mRNA from ...

journal_title：Biochemical and biophysical research communications

authors： Langlois-Gallet D,Dazord A

更新日期：1984-03-30 00:00:00

abstract：:Recently, increasing evidences demonstrate that circular RNAs (circRNAs) exert very important functions in the progression of human cancers. However, the functions and molecular mechanism of circ_0067934 in hepatocellular carcinoma (HCC) are largely unknown. In the present study, we found that the expression of circ_0...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Lu G,Luo Z,Gui F,Wu J,Zhang D,Ni Y

更新日期：2018-03-04 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies and column chromatography on QAE-Sephadex in three different groups: control, type II diabetic, and obese individuals. It was found that PMN phosphofructokinase in the t...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1996-08-23 00:00:00

abstract：:RNA extracts from the isthmus of laying hen oviduct contain truncated 5S RNA molecules that were found to be shorter at their 5' terminus as compared to native 5S RNA I and II. Moreover one of the truncated species differs from 5S RNA I by the absence of the 3' end nucleotide. The truncated forms increase of about 70%...

journal_title：Biochemical and biophysical research communications

authors： Keith G,Nys Y,Fix C,Heyman T

更新日期：1986-08-14 00:00:00

abstract：:Germline stem cells (GSCs) are attractive biological models because of their strict control on pluripotency gene expression, and their potential for huge epigenetic changes in a short period of time. Few data exists on the cooperative impact of GSC-specific genes on differentiated cells. In this study, we over-express...

journal_title：Biochemical and biophysical research communications

authors： Farshchian M,Matin MM,Bahrami M,Geerts D,Dastpak M,Shahriyari M,Tajeran M,Mirahmadi M,Bahrami AR

更新日期：2016-11-25 00:00:00

abstract：:Systemic sclerosis (SSc) or scleroderma is a generalized disorder of connective tissue. The etiology is poorly understood; however, both genetic and environmental factors have been implicated. To investigate the disease-susceptible gene for SSc, we examined the association of the disease with a gene (COL1A2) for type ...

journal_title：Biochemical and biophysical research communications

authors： Hata R,Akai J,Kimura A,Ishikawa O,Kuwana M,Shinkai H

更新日期：2000-05-27 00:00:00

abstract：:Accumulating evidence has linked deregulation of microRNA-495 (miR-495) to tumorigenesis; however, its function in tumor progression is controversial. This work was undertaken to explore the expression and biological roles of miR-495 in bladder cancer. The expression of miR-495 was examined in 67 pairs of bladder canc...

journal_title：Biochemical and biophysical research communications

authors： Tan M,Mu X,Liu Z,Tao L,Wang J,Ge J,Qiu J

更新日期：2017-02-05 00:00:00

abstract：:We examined the effects of recombinant human C-reactive protein (rhCRP) on atherosclerosis-related factors in cultured human coronary artery endothelial and smooth muscle cells (HCAECs and HCASMCs). After removing endotoxin from commercial rhCRP preparations using the appropriate column, the purified (P)-rhCRP retaine...

journal_title：Biochemical and biophysical research communications

authors： Nagoshi Y,Kuwasako K,Cao YN,Kitamura K,Eto T

更新日期：2004-02-20 00:00:00

abstract：:Chronic infection with hepatitis B virus (HBV) is associated with the majority of cases of hepatocellular carcinoma (HCC) in China. Despite this, there is no effective method for the early detection of HBV-induced liver cancer. Aberrant fucosylation is known to occur during the development of HCC. We, therefore, devel...

journal_title：Biochemical and biophysical research communications

authors： Liao J,Zhang R,Qian H,Cao L,Zhang Y,Xu W,Li J,Wu M,Yin Z

更新日期：2012-04-06 00:00:00

abstract：:We had previously reported a prostaglandin E synthase (bmPGES) in the silkworm Bombyx mori that catalyzes the isomerization of PGH2 to PGE2. The present study aimed to provide a genome-editing characterization of bmPGES in B. mori. Results showed bmPGES gene disruption to result in a reduced content of PGE2. The chang...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto K,Tsubota T,Uno T,Tsujita Y,Yokota S,Sezutsu H,Mita K

更新日期：2020-01-08 00:00:00

abstract：:Estrogen receptor alpha (ERalpha), a ligand controlled transcription factor, plays an important role in breast cancer growth and endocrine therapy. Tamoxifen (TAM) antagonizes ERalpha activity and has been applied in breast cancer treatment. TAM-bound ERalpha associates with nuclear receptor-corepressors. Mitogen-acti...

journal_title：Biochemical and biophysical research communications

authors： Hong W,Chen L,Li J,Yao Z

更新日期：2010-05-28 00:00:00

abstract：:This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic domain and a C-terminal anticodon-binding domain with...

journal_title：Biochemical and biophysical research communications

authors： Fujisawa A,Toki R,Miyake H,Shoji T,Doi H,Hayashi H,Hanabusa R,Mutsuro-Aoki H,Umehara T,Ando T,Noguchi H,Voet A,Park SY,Tamura K

更新日期：2019-04-02 00:00:00

abstract：:Ceramide kinase (CERK) converts ceramide to ceramide-1-phosphate (C1P), which has recently emerged as a new bioactive molecule capable of regulating diverse cellular functions. The N-terminus of the CERK protein encompasses a sequence motif known as a pleckstrin homology (PH) domain. Although the PH domain was previou...

journal_title：Biochemical and biophysical research communications

authors： Kim TJ,Mitsutake S,Igarashi Y

更新日期：2006-04-07 00:00:00

abstract：:Hepatic glucokinase is induced by insulin and repressed by glucagon. The effects of epidermal growth factor (EGF) on glucokinase expression were investigated in rat hepatocytes. EGF does not affect the decline in glucokinase activity in hepatocytes cultured for 48h in the absence of insulin, but it counteracts the inc...

journal_title：Biochemical and biophysical research communications

authors： Beresford GW,Agius L

更新日期：1994-06-15 00:00:00

abstract：:Little is known about the gene expression in human oocytes and early embryo development because of the rare availability of the materials. The recent advancement of biotechnology has allowed one to analyze the gene expression in single human oocytes and preimplantation embryos. Gene expression of human lactate dehydro...

journal_title：Biochemical and biophysical research communications

authors： Li SS,Liu YH,Tseng CN,Singh S

更新日期：2006-02-03 00:00:00

abstract：:We isolated genomic DNA containing the entire sequence of ZF5, which was originally identified by its ability to repress the mouse c-myc promoter and which was characterized as one of the POZ (Poxvirus and zinc finger) proteins. The POZ motif is a protein-protein interaction interface found at the N-terminal region of...

journal_title：Biochemical and biophysical research communications

authors： Yokoro K,Yanagidani A,Obata T,Yamamoto S,Numoto M

更新日期：1998-05-29 00:00:00

abstract：:To gain further information on the role of mitochondrial transcription factor A (TFAM) in mitochondrial biogenesis, we studied the post-translational modifications of the protein in 6- and 28-month-old rat liver. Mass spectrometry and immunoblot analysis revealed that TFAM was acetylated at a single lysine residue and...

journal_title：Biochemical and biophysical research communications

authors： Dinardo MM,Musicco C,Fracasso F,Milella F,Gadaleta MN,Gadaleta G,Cantatore P

更新日期：2003-01-31 00:00:00

abstract：:In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activat...

journal_title：Biochemical and biophysical research communications

authors： Renard E,Grigorescu F,Lavabre C,Kahn CR

更新日期：1995-04-06 00:00:00

abstract：:The synthetic (1-->6)-alpha-D-glucopyranan with branching and without branching were tested as a new hypoglycaemic drug. (1-->6)-alpha-D-glucopyranan having an alpha-D-glucopyranosyl branch at the C-3 position (1) showed a remarkable hypoglycaemic activity on i.p. injection to mice. The polysaccharide having both alph...

journal_title：Biochemical and biophysical research communications

authors： Hatanaka K,Song SC,Maruyama A,Kobayashi A,Kuzuhara H,Akaike T

更新日期：1992-10-15 00:00:00

abstract：:Cognitive impairment, acute or long-term, is a common complication in patients with severe bacterial infection. However, the underlying mechanisms are not fully verified and effective medicine is not available in clinics. Interferon gamma (IFNγ) is a pivotal cytokine against infection and is believed to be a tune in h...

journal_title：Biochemical and biophysical research communications

authors： Lu Y,Yang Y,Peng Z,Xie L,Zhong X,Liang F,Yuan C,Lu B

更新日期：2020-12-17 00:00:00