当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

Abstract：

:Carcinogenesis is a long process that results in the accumulation of genetic alterations primarily in genes involved in the regulation of signalling pathways relevant for the regulation of cell growth and the cell cycle. Alteration of additional genes regulating cell adhesion and migration, angiogenesis, apoptosis, and drug resistance confers to the cancer cells a more malignant phenotype. Genes that participate in the regulation of some critical metabolic pathways are also altered during this process. Choline kinase (ChoK) has been reported to belong to the latter family of cancer-related genes. Recently, we have reported that increased activity of ChoK is observed in human breast carcinomas. Here, we provide further evidence that ChoK dysregulation is a frequent event found in a variety of human tumors such as lung, colorectal, and prostate tumors. Furthermore, a large panel of human tumor-derived cell lines also show increased ChoK activity when compared to appropriate non-tumorigenic or primary cells. These findings strongly support the role of ChoK alterations in the carcinogenic process in human tumors, suggesting that ChoK could be used as a tumor marker.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ramírez de Molina A,Rodríguez-González A,Gutiérrez R,Martínez-Piñeiro L,Sánchez J,Bonilla F,Rosell R,Lacal J

doi

10.1016/s0006-291x(02)00920-8

subject

Has Abstract

pub_date

2002-08-23 00:00:00

pages

580-3

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X02009208

journal_volume

296

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Expression of CYP19 (aromatase) mRNA in the human temporal lobe.

    abstract：:The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking. Therefore, we investigated CYP19 mRNA expr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8337

    authors： Stoffel-Wagner B,Watzka M,Steckelbroeck S,Schwaab R,Schramm J,Bidlingmaier F,Klingmüller D

    更新日期：1998-03-27 00:00:00

  • Silencer-mediated repression and non-mediated activation of BDNF and c-fos gene promoters in primary glial or neuronal cells.

    abstract：:Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcript...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0974

    authors： Tabuchi A,Nakatani C,Nakaoka R,Naruse Y,Kojima T,Mori N,Tsuda M

    更新日期：1999-08-02 00:00:00

  • Monoclonal antibody that blocks phosphoinositide-dependent activation of mouse tumor DNA polymerase alpha.

    abstract：:A monoclonal antibody (MaB) against mouse sarcoma DNA polymerase alpha was isolated from the culture medium of an IgG-secreting hybridoma. The MaB demonstrated reactivity against two murine DNA polymerase alpha preparations and a calf thymus DNA polymerase alpha. Murine sarcoma polymerase was activated in vitro by pho...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80334-5

    authors： Sylvia VL,Norman JO,Curtin GM,Busbee DL

    更新日期：1986-11-26 00:00:00

  • Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer.

    abstract：:We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they possessed diverse suga...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1712

    authors： Aono A,Hazama M,Notoya K,Taketomi S,Yamasaki H,Tsukuda R,Sasaki S,Fujisawa Y

    更新日期：1995-05-25 00:00:00

  • 5-Fluorocytosine combined with Fcy-hEGF fusion protein targets EGFR-expressing cancer cells.

    abstract：:Human epithelial cancers account for approximately 50% of all cancer deaths. This type of cancer is characterized by excessive activation and expression of the epidermal growth factor receptor (EGFR). The EGFR pathway is critical for cancer cell proliferation, survival, metastasis and angiogenesis. The EGF-EGFR signal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.10.050

    authors： Lan KH,Shih YS,Chang CA,Yen SH,Lan KL

    更新日期：2012-11-16 00:00:00

  • Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress.

    abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.07.088

    authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

    更新日期：2008-10-03 00:00:00

  • PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.

    abstract：:The regulated secretory pathway is a specialized form of protein secretion found in endocrine and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that utilizes this pathway to be trafficked to dense core secretory granules (DCSGs). Within this organelle, POMC is processed to multiple bioactive ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.11.085

    authors： Dirk BS,End C,Pawlak EN,Van Nynatten LR,Jacob RA,Heit B,Dikeakos JD

    更新日期：2018-12-09 00:00:00

  • Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene.

    abstract：:We have isolated and characterized the 5'-flanking region of the mouse RECK gene aiming to understand the mechanism of oncogene-mediated suppression of RECK gene expression. The upstream 52-base region was found to contain a promoter activity which is, to some extent, suppressed by the ras oncogene. This region contai...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1552

    authors： Sasahara RM,Takahashi C,Noda M

    更新日期：1999-11-02 00:00:00

  • In vitro demonstration by the rate assay of the presence of small pore in the outer membrane of Pseudomonas aeruginosa.

    abstract：:Determination of the rates of saccharide diffusions by the proteoliposomes showed that the outer membrane of Pseudomonas aeruginosa only possesses small diffusion pores and that protein F might have not been involved in the pore formation. Proteoliposomes containing stachyose or Dextan T-10 showed the same relative di...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80865-9

    authors： Yoshihara E,Gotoh N,Nakae T

    更新日期：1988-10-14 00:00:00

  • Human adipose-derived stem cells and simvastatin-functionalized biomimetic calcium phosphate to construct a novel tissue-engineered bone.

    abstract：:To repair bone defects, we evaluate the in-vitro and in-vivo osteogenic activities of a novel tissue-engineered bone (TEB) by elaborately combining biomimetic calcium phosphate (BioCaP) granules with internally-incorporated simvastatin (SIM) and human adipose-derived stem cells (hASCs). First, we constructed BioCaP wi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.11.150

    authors： Zhang X,Jiang W,Liu Y,Zhang P,Wang L,Li W,Wu G,Ge Y,Zhou Y

    更新日期：2018-01-01 00:00:00

  • Ionophore-induced Cl- transport in human erythrocyte suspensions: a multinuclear magnetic resonance study.

    abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90678-e

    authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

    更新日期：1992-04-30 00:00:00

  • Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry.

    abstract：:The complete covalent structure of the gamma 2 subunit of bovine brain G proteins was determined by peptide mapping using matrix-assisted laser desorption ionization and electrospray ionization mass spectrometry and by partial sequencing using tandem mass spectrometry. Fragments were identified in proteolytic digests ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1979

    authors： Wilcox MD,Schey KL,Busman M,Hildebrandt JD

    更新日期：1995-07-17 00:00:00

  • The structure of SecB/OmpA as visualized by electron microscopy: The mature region of the precursor protein binds asymmetrically to SecB.

    abstract：:SecB, a molecular chaperone in Escherichia coli, binds a subset of precursor proteins that are exported across the plasma membrane via the Sec pathway. Previous studies showed that SecB bound directly to the mature region rather than to the signal sequence of the precursor protein. To determine the binding pattern of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.062

    authors： Tang Y,Pan X,Tai PC,Sui SF

    更新日期：2010-03-19 00:00:00

  • The co-chaperone CHIP is induced in various stresses and confers protection to cells.

    abstract：:The C-terminus of Hsp70 interacting protein (CHIP) is being considered to be a cellular quality control E3 ubiquitin ligase because of its ability to degrade misfolded proteins in association with heat shock chaperones. The neuroprotective role of CHIP also has been implicated in several familial neurodegenerative dis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.04.018

    authors： Dikshit P,Jana NR

    更新日期：2007-06-08 00:00:00

  • Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro.

    abstract：:The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.04.107

    authors： Bruzzone S,Battaglia F,Mannino E,Parodi A,Fruscione F,Basile G,Salis A,Sturla L,Negrini S,Kalli F,Stringara S,Filaci G,Zocchi E,Fenoglio D

    更新日期：2012-05-25 00:00:00

  • Involvement of TOR signaling motif in the regulation of plant autophagy.

    abstract：:In our previous studies, we have demonstrated that a stretch of amino-acid sequences identified from Arabidopsis ribosomal S6 kinase 1 (AtS6K1) provided a plant version of the TOS (TOR-signaling) motif, mediating the interaction with the Raptor protein in the TOR (Target of Rapamycin) kinase complex. Here we report th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.027

    authors： Son O,Kim S,Kim D,Hur YS,Kim J,Cheon CI

    更新日期：2018-06-27 00:00:00

  • MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha.

    abstract：:The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.06.061

    authors： Hua W,Sa KD,Zhang X,Jia LT,Zhao J,Yang AG,Zhang R,Fan J,Bian K

    更新日期：2015-08-07 00:00:00

  • Molecular cloning and characterization of rat lin-10.

    abstract：:In Caenorhabditis elegans, the vulval induction is mediated by tyrosine kinase receptor/Ras signal transduction pathway composed of the lin-3, let-23, and let-60 products. In addition to these gene products, the lin-2, lin-7, and lin-10 products are also implicated in this pathway. Lin-2 encodes a MAGUK and lin-7 enco...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8142

    authors： Ide N,Hirao K,Hata Y,Takeuchi M,Irie M,Yao I,Deguchi M,Toyoda A,Nishioka H,Mizoguchi A,Takai Y

    更新日期：1998-02-13 00:00:00

  • Cholesterol depletion induces ANTXR2-dependent activation of MMP-2 via ERK1/2 phosphorylation in neuroglioma U251 cell.

    abstract：:Cholesterol is a critical component of lipid rafts implicated in regulating multiple signal transduction. The anthrax toxin receptor 2 (ANTXR2) is a type I membrane protein acting as the second receptor for the anthrax toxin. In this study, we first investigated the association between cholesterol and ANTXR2. We provi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.001

    authors： Zou J,Xu L,Ju Y,Zhang P,Wang Y,Zhang B

    更新日期：2014-09-12 00:00:00

  • Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

    abstract：:Eukaryotic initiation factor 2Bε (eIF2Bε) plays a critical role in the initiation of mRNA translation and its expression and guanine nucleotide exchange activity are major determinants of the rate of protein synthesis. In this work we provide evidence that the catalytic epsilon subunit of eIF2B is subject to ubiquitin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.053

    authors： Tuckow AP,Kazi AA,Kimball SR,Jefferson LS

    更新日期：2013-06-21 00:00:00

  • Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain.

    abstract：:Tumor necrosis factor (TNF) contributes to insulin resistance by binding to the 55kDa TNF receptor (TNF-R55), resulting in serine phosphorylation of proteins such as insulin receptor (IR) substrate (IRS)-1, followed by reduced tyrosine phosphorylation of IRS-1 through the IR and, thereby, diminished IR signal transduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.140

    authors： Csehi SB,Mathieu S,Seifert U,Lange A,Zweyer M,Wernig A,Adam D

    更新日期：2005-04-01 00:00:00

  • Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD.

    abstract：:We have previously shown that a high cholesterol (HC) diet results in increases in microglia load and levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in the brains of wild type (WT) and apolipoprotein E knockout (ApoE-/-) mice. In the present investigation, we analyzed whether treatment with rosuvastatin,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.035

    authors： Famer D,Wahlund LO,Crisby M

    更新日期：2010-11-12 00:00:00

  • The antimicrobial action of histones in the reproductive tract of cow.

    abstract：:An infection of any part of female reproductive tract can severely interfere with fertility and reproduction. The fluids and epithelium from the lumen of the female reproductive tract (uterus, oviduct and ovarian follicle) are a known source of antimicrobial action in several species. In this study, we compared the an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.12.077

    authors： Dráb T,Kračmerová J,Hanzlíková E,Černá T,Litváková R,Pohlová A,Tichá M,Přikryl P,Liberda J

    更新日期：2014-01-17 00:00:00

  • A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.

    abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.03.030

    authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

    更新日期：2011-04-08 00:00:00

  • Differential regulation of multiple neuroreceptors in a somatic cell hybrid by inhibitors of glycoprotein processing.

    abstract：:Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW). TM t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90403-1

    authors： McLawhon RW,Berry-Kravis E,Dawson G

    更新日期：1986-02-13 00:00:00

  • A hypothetical structural role for proline residues in the flanking segments of protein-protein interaction sites.

    abstract：:An examination of more than 1600 protein-protein interaction sites indicated that proline is the residue most commonly found near interaction sites. A structural role is distinguished for these proline residues in the flanking segments of protein-protein interaction sites. The unique nature of proline helps protect th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2084

    authors： Kini RM,Evans HJ

    更新日期：1995-07-26 00:00:00

  • Ceramide-induced apoptosis is mediated by caspase activation independently from retinoblastoma protein post-translational modification.

    abstract：:Recent evidence suggests that untimely retinoblastoma protein (RB) dephosphorylation and/or proteolytic degradation might provide key events down-stream cysteine protease (caspase) activation in apoptosis induction. We have dealt with this issue by studying apoptosis induced by N-hexanoylsphingosine (C6-Cer) in CHP-10...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8184

    authors： Spinedi A,Amendola A,Di Bartolomeo S,Piacentini M

    更新日期：1998-02-24 00:00:00

  • Characterization of a Mr 25,000 basic fibroblast growth factor form in adult, regenerating, and fetal rat liver.

    abstract：:A heparin-binding Mr 25,000 immunoreactive bFGF-like protein (ir-bFGF) is recognized in adult rat liver extract by affinity-purified polyclonal anti-human placental bFGF antibodies. Hepatic levels of this protein increase 4-fold in regenerating rat liver during the first 48 h after partial hepatectomy. Also, they appe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91794-4

    authors： Presta M,Statuto M,Rusnati M,Dell'Era P,Ragnotti G

    更新日期：1989-11-15 00:00:00

  • Degradation of gamma D- and gamma s-crystallins in human lenses.

    abstract：:The aim of this study was to determine age-related degradation of gammaD-crystallin and the cleavage sites in the connecting peptide regions of the two domains of gammaD- and gammas-crystallins. The water-soluble (WS) proteins from lenses of donors of different ages and a purified gamma-crystallin fraction were analyz...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9728

    authors： Srivastava OP,Srivastava K

    更新日期：1998-12-18 00:00:00

  • Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes.

    abstract：:Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91714-4

    authors： Noji S,Matsuo T,Koyama E,Yamaai T,Nohno T,Matsuo N,Taniguchi S

    更新日期：1990-04-16 00:00:00