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Illegitimate recombination in a bovine papillomavirus shuttle vector: a high level of site specificity.

Abstract：

:Recombination in a bovine papillomavirus shuttle vector carrying direct repeats of Moloney murine leukemia virus LTR sequence was examined. Differently from similar vectors carrying direct repeats of SV40 polyA addition signal or neomycin resistance gene, the vector exhibited no homologous recombination between the repeats. Instead, illegitimate recombination took place. There were two major types of recombination products from the restriction cleavage pattern. The plasmids in independent cellular clones belonging to the same recombination type shared the identical crossover point. Thus, in this plasmid, illegitimate recombination occurred at preferential sites involving exactly the same sequences.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kitamura Y,Naito A,Yoshikura H

doi

10.1016/0006-291x(91)91362-g

subject

Has Abstract

pub_date

1991-08-30 00:00:00

pages

251-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91362-G

journal_volume

179

pub_type

杂志文章

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