Abstract:
:Treatment of the rat C6 glioma cell line with interleukin-1 beta (IL-1 beta) resulted in an accumulation of cytosolic phospholipase A2 (cPLA2) in mRNA level. The increase of cPLA2 in mRNA level was observed at 6 hours after treatment of IL-1 beta and reached to the maximal level at 12 hours. The accumulation also remained sustained for up to 72 hours. Dose response curve of IL-1 beta showed that as little as 40 units/ml concentration induced the accumulation of mRNA and 100 units/ml concentration showed the maximal effect. In contrast, cyclooxygenase 2 gene was not affected with treatment of IL-1 beta.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Ozaki M,Morii H,Qvist R,Watanabe Ydoi
10.1006/bbrc.1994.2622subject
Has Abstractpub_date
1994-11-30 00:00:00pages
12-7issue
1eissn
0006-291Xissn
1090-2104pii
S0006291X84726222journal_volume
205pub_type
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