Interleukin-1 beta induces cytosolic phospholipase A2 gene in rats C6 glioma cell line.

Abstract:

:Treatment of the rat C6 glioma cell line with interleukin-1 beta (IL-1 beta) resulted in an accumulation of cytosolic phospholipase A2 (cPLA2) in mRNA level. The increase of cPLA2 in mRNA level was observed at 6 hours after treatment of IL-1 beta and reached to the maximal level at 12 hours. The accumulation also remained sustained for up to 72 hours. Dose response curve of IL-1 beta showed that as little as 40 units/ml concentration induced the accumulation of mRNA and 100 units/ml concentration showed the maximal effect. In contrast, cyclooxygenase 2 gene was not affected with treatment of IL-1 beta.

authors

Ozaki M,Morii H,Qvist R,Watanabe Y

doi

10.1006/bbrc.1994.2622

subject

Has Abstract

pub_date

1994-11-30 00:00:00

pages

12-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X84726222

journal_volume

205

pub_type

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