Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.

abstract：:To elucidate genetic determinants of insulin resistance, we investigated insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) genes, in vitro IR function and in vivo insulin sensitivity in a family with Type A syndrome. Two missense IR mutations (Asp59Gly and Leu62Pro) found in the proband, resulted in reduc...

journal_title：Biochemical and biophysical research communications

authors： Rouard M,Macari F,Bouix O,Lautier C,Brun JF,Lefebvre P,Renard E,Bringer J,Jaffiol C,Grigorescu F

更新日期：1997-05-29 00:00:00

abstract：:As part of our studies on polyamine biosynthesis in yeast, the metabolism of methylthioadenosine was studied in a mutant that lacks methylthioadenosine phosphorylase (meu1delta). The nucleoside accumulates in this mutant and is mainly excreted into the culture medium. Intracellular accumulation of the nucleoside is en...

journal_title：Biochemical and biophysical research communications

authors： Chattopadhyay MK,Tabor CW,Tabor H

更新日期：2006-04-28 00:00:00

abstract：:Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to ma...

journal_title：Biochemical and biophysical research communications

authors： Knott TJ,Eddy RL,Robertson ME,Priestley LM,Scott J,Shows TB

更新日期：1984-11-30 00:00:00

abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

journal_title：Biochemical and biophysical research communications

authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

更新日期：2019-04-30 00:00:00

abstract：:F-actin rearrangement is an early event in burn-induced endothelial barrier dysfunction. HSP27, a target of p38 MAPK/MK2 pathway, plays an important role in actin dynamics through phosphorylation. The question of whether HSP27 participates in burn-related endothelial barrier dysfunction has not been identified yet. He...

journal_title：Biochemical and biophysical research communications

authors： Sun HB,Ren X,Liu J,Guo XW,Jiang XP,Zhang DX,Huang YS,Zhang JP

更新日期：2015-07-31 00:00:00

abstract：:A novel 6-substituted acyclouridine derivative, 1-[(2-hydroxy-ethoxy) methyl]-6-phenylthiothymine (HEPT), has proved to be a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. HEPT inhibits HIV-1 replication in various T4 cell cultures as well as peripheral blood lymphocytes and ma...

journal_title：Biochemical and biophysical research communications

authors： Baba M,Tanaka H,De Clercq E,Pauwels R,Balzarini J,Schols D,Nakashima H,Perno CF,Walker RT,Miyasaka T

更新日期：1989-12-29 00:00:00

abstract：:We previously reported that tissue damage during brain infarction was mainly caused by inactivation of proteins by acrolein. This time, it was tested why brain infarction increases in parallel with aging. A mouse model of photochemically induced thrombosis (PIT) was studied using 2, 6, and 12 month-old female C57BL/6 ...

journal_title：Biochemical and biophysical research communications

authors： Uemura T,Watanabe K,Ishibashi M,Saiki R,Kuni K,Nishimura K,Toida T,Kashiwagi K,Igarashi K

更新日期：2016-04-29 00:00:00

abstract：:The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes. Microfold cell inducer (MCi) cells in GALTs are the recently identified mesenchymal cel...

journal_title：Biochemical and biophysical research communications

authors： Nagashima K,Sawa S,Nitta T,Prados A,Koliaraki V,Kollias G,Nakashima T,Takayanagi H

更新日期：2017-11-04 00:00:00

abstract：:Eph receptor tyrosine kinases (RTKs) and their ephrin ligands play multiple roles in the developing nervous system, including cell segregation, axon guidance and synaptic plasticity. Here we report the expression and function of EphA7 in Xenopus hindbrain development. EphA7 is specifically expressed in the hindbrain t...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Sun J,Li C,Mao B

更新日期：2016-10-28 00:00:00

abstract：:To date only about 15 abundantly expressed osmoresponsive genes/proteins have been described in rice cultivars. Using in vivo radiolabeling followed by two-dimensional electrophoresis and autoradiography, a record number of at least 35 salinity stress-induced polypeptides (14-90 kDa) and 17 salt stress-repressed polyp...

journal_title：Biochemical and biophysical research communications

authors： Ramani S,Apte SK

更新日期：1997-04-28 00:00:00

abstract：:We have applied serial analysis of gene expression for studying the molecular mechanism of the rat liver regeneration in the model of 70% partial hepatectomy. We generated three SAGE libraries from a normal control liver (NL library: 52,343 tags), from a sham control operated liver (Sham library: 51,028 tags), and fro...

journal_title：Biochemical and biophysical research communications

authors： Cimica V,Batusic D,Haralanova-Ilieva B,Chen Y,Hollemann T,Pieler T,Ramadori G

更新日期：2007-08-31 00:00:00

abstract：:It has been reported that changes in deoxynucleotide pool levels following exposure to UV might lead to an overestimation of the UV-induced depression in DNA synthesis as analyzed by incorporation of 3H-thymidine (1). We attempted to determine the importance of such pool effects in two ways. First, we examined the gra...

journal_title：Biochemical and biophysical research communications

authors： Griffiths TD,Ling SY

更新日期：1984-09-17 00:00:00

abstract：:We have studied the internalization and subsequent nuclear localization of [125I]-rTNF-alpha in a human osteoblast-like cell line, HOS TE85. TNF-alpha is rapidly internalized and optimum cellular levels are achieved in approximately 20 minutes at 37 degrees C. A portion of the internalized cytokine is translocated to ...

journal_title：Biochemical and biophysical research communications

authors： Panagakos FS,Kumar S

更新日期：1994-06-30 00:00:00

abstract：:The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive seq...

journal_title：Biochemical and biophysical research communications

authors： Barra D,Martini F,Angelaccio S,Bossa F,Gavilanes F,Peterson D,Bullis B,Schirch L

更新日期：1983-11-15 00:00:00

abstract：:p73 is one of the p53 family members which are transcription factors involved in the regulation of cell proliferation, apoptosis, and differentiation. In this study, we cloned the p73 cDNA from zebrafish ovary RNA. The consensus open reading frame (1923bp) encodes a polypeptide of 640 amino acids which shares 70-95% i...

journal_title：Biochemical and biophysical research communications

authors： Pan H,Dung HN,Hsu HM,Hsiao KM,Chen LY

更新日期：2003-07-25 00:00:00

abstract：:The CitA citrate transporter in Salmonella typhimurium is encoded by the citA gene and consists of 434 amino acid residues that probably include 12 membrane-spanning segments [Shimamoto. T., et al. (1991) J. Biochem. 110, 22-28]. CitA mutants with altered substrate specificities were isolated by in vitro mutagenesis u...

journal_title：Biochemical and biophysical research communications

authors： Shimamoto T,Negishi K,Tsuda M,Tsuchiya T

更新日期：1996-09-13 00:00:00

abstract：:We have found that the alkyl-lysophospholipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) was able to induce apoptosis in human promyelocytic HL-60 leukemic cells, as evidenced by the internucleosomal degradation of the cellular DNA into the characteristic 180-200 bp DNA fragments. This effect was o...

journal_title：Biochemical and biophysical research communications

authors： Mollinedo F,Martínez-Dalmau R,Modolell M

更新日期：1993-04-30 00:00:00

abstract：:Adenovirus vector is one of the most widely used vectors in gene therapy applications for the treatment of diverse human diseases including cancer. In this study, we showed that infection with E1E3-deleted recombinant human adenovirus serotype 5 reduced human telomerase reverse transcriptase (hTERT) mRNA levels in hep...

journal_title：Biochemical and biophysical research communications

authors： Lee CH,Kim HW,Kim T,Lee SW

更新日期：2015-03-20 00:00:00

abstract：:The quiescent and proliferating status of the cell appears characterized by two different tRNA populations. The tRNA species changed both as relative percentage of total tRNA and in absolute concentration. The changes seem causally related to the proliferation status of the cell as tRNAs from proliferating hepatocytes...

journal_title：Biochemical and biophysical research communications

authors： Kanduc D

更新日期：1996-04-25 00:00:00

abstract：:The causative agent of Lyme disease, Borrelia burgdorferi, requires shifts in gene expression to undergo its natural enzootic cycle between tick and vertebrate hosts. mRNA decay mechanisms play significant roles in governing gene expression in other bacteria, but are not yet characterized in B. burgdorferi. RNase III ...

journal_title：Biochemical and biophysical research communications

authors： Snow S,Bacon E,Bergeron J,Katzman D,Wilhelm A,Lewis O,Syangtan D,Calkins A,Archambault L,Anacker ML,Schlax PJ

更新日期：2020-08-20 00:00:00

abstract：:In a number of cell lines responsive to basic fibroblast growth factor (bFGF), two major tyrosine phosphorylated proteins, of molecular weights around 120kDa and 90kDa, are precipitated along with the tyrosine phosphatase SHP2 from the lysates of stimulated cells. The docker protein Gab-1 represents at least part of t...

journal_title：Biochemical and biophysical research communications

authors： Ong SH,Lim YP,Low BC,Guy GR

更新日期：1997-09-08 00:00:00

abstract：:A monoclonal antibody against Neurospora soluble adenylate cyclase was obtained. The antibody inhibits cyclase activities from several lower eucaryotic organisms but not activities associated to testicular cytosol or turkey erythrocyte membranes. ...

journal_title：Biochemical and biophysical research communications

authors： Molina y Vedia L,Torruella M,Attar R,Podesta E,Reig JA,Flawiá MM,Torres HN

更新日期：1983-06-29 00:00:00

abstract：:Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) modulates phospho-signaling by catalyzing rotation of the bond between a phosphorylated serine or threonine before proline in proteins. As depletion of PIN1 increased inflammatory protein expression in cultured endothelial cells treated with bacterial endot...

journal_title：Biochemical and biophysical research communications

authors： Liu T,Schneider RA,Lee NY,Hoyt DG

更新日期：2014-09-26 00:00:00

abstract：:Superoxide production by neutrophils induced by 1-oleoyl-2-acetyl-sn-glycerol at concentrations below 100 microM was enhanced by extracellular calcium ions, while that of phorbol myristate acetate was unaffected. Verapamil, a calcium-channel blocker, more effectively inhibited the superoxide production induced by 1-ol...

journal_title：Biochemical and biophysical research communications

authors： Ozaki Y,Kume S,Ohashi T,Niwa Y

更新日期：1986-01-29 00:00:00

abstract：:When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing acti...

journal_title：Biochemical and biophysical research communications

authors： Hiro D,Ito A,Matsuta K,Mori Y

更新日期：1986-10-30 00:00:00

abstract：:Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. T...

journal_title：Biochemical and biophysical research communications

authors： Mori H,Hamada Y,Kawaguchi M,Honda T,Kondo J,Ihara Y

更新日期：1989-03-31 00:00:00

abstract：:A synthetic heptapeptide H-Ser-Phe-Phe-Leu-Arg-Asn-Pro-NH2, which corresponds to the ligand peptide latent in rodent thrombin receptors, was able to activate the thrombin receptor with no thrombin. In order to evaluate the structural requisites of two consecutive phenylalanines, three sets of analogs with substitution...

journal_title：Biochemical and biophysical research communications

authors： Shimohigashi Y,Nose T,Okazaki M,Satoh Y,Ohno M,Costa T,Shimizu N,Ogino Y

更新日期：1994-08-30 00:00:00

abstract：:GMP-140 (CD62; PADGEM) is a member of the selectin family expressed highly at the surface of platelets and endothelial cells by agonists such as thrombin or phorbol esters. Previous studies indicate that the lectin domain of GMP-140 recognizes sialosyl-Le(x) (SLex) and to a lesser extent Le(x) (Polley MJ, et al., Proc...

journal_title：Biochemical and biophysical research communications

authors： Handa K,Nudelman ED,Stroud MR,Shiozawa T,Hakomori S

更新日期：1991-12-31 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of cardiovascular diseases and are modified in response to a variety of stimuli such as bioactive peptides, cytokines and/or grown factors. In this study, we demonstrated that angiotensin II (Ang II) induces a time- and dose-dependent increase...

journal_title：Biochemical and biophysical research communications

authors： Jiménez E,Pérez de la Blanca E,Urso L,González I,Salas J,Montiel M

更新日期：2009-03-20 00:00:00

abstract：:The change of transferrin receptors in regenerating rat liver cells after partial hepatectomy was demonstrated. The binding of 125I-labeled transferrin to the cells began to increase after 24 h of partial hepatectomy and reached about double that of the non-operated normal rat liver cells. A Scatchard analysis of bind...

journal_title：Biochemical and biophysical research communications

authors： Tei I,Makino Y,Kadofuku T,Kanamaru I,Konno K

更新日期：1984-06-15 00:00:00