SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells.

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The...

journal_title：Biochemical and biophysical research communications

authors： Folkers K,Langsjoen P,Nara Y,Muratsu K,Komorowski J,Richardson PC,Smith TH

更新日期：1988-06-16 00:00:00

abstract：:Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is c...

journal_title：Biochemical and biophysical research communications

authors： Kim KJ,Yun JH,Heo JI,Lee EH,Min HS,Choi TH,Cho CH

更新日期：2014-11-14 00:00:00

abstract：:Recombinant human OP-1 stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) significantly and in a dose-dependent manner in rat bone marrow cell culture. Newly formed MNCs either induced by hOP-1 alone or with 1,25(OH)2D3 were also positive for vitronectin recepto...

journal_title：Biochemical and biophysical research communications

authors： Hentunen TA,Lakkakorpi PT,Tuukkanen J,Lehenkari PP,Sampath TK,Väänänen HK

更新日期：1995-04-17 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet in cooked meat. To examine if PhIP and its reactive metabolite N-hydroxy-PhIP inhibit apoptosis in human mammary epithelial MCF-10A cells, confluent cultures deprived of serum and growth factors were incubate...

journal_title：Biochemical and biophysical research communications

authors： Venugopal M,Agarwal R,Callaway A,Schut HA,Snyderwine EG

更新日期：1999-12-09 00:00:00

abstract：:Quercetin is one of the most prominent dietary antioxidants. During its antioxidant activity, quercetin becomes oxidized into its o-quinone/quinone methide QQ. QQ is toxic since it instantaneously reacts with thiols of, e.g., proteins. In cells, QQ will initially form an adduct with glutathione (GSH), giving GSQ. We h...

journal_title：Biochemical and biophysical research communications

authors： Boots AW,Balk JM,Bast A,Haenen GR

更新日期：2005-12-16 00:00:00

abstract：:Neuroblastoma LAN-5 cells exposed to retinoic acid cease to multiply and extend neurite outgrowths acquiring a neuronal phenotype. We now report that protein kinase C-theta; (PKC-theta;) isozyme is involved in this differentiation process due to the following findings: (i) PKC-theta; is expressed by LAN-5 cells as a n...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Passalacqua M,Pedrazzi M,Pontremoli S,Melloni E

更新日期：2000-12-20 00:00:00

abstract：:The Rex-family repressors sense redox levels by alternative binding to NADH or NAD(+). RSP is the homologue of Rex in Thermoanaerobacter ethanolicus JW200(T) and regulates ethanol fermentation in this obligate anaerobe. The dimeric repressor binds to DNA by an open conformation. The crystal structure of RSP/α-NAD(+) c...

journal_title：Biochemical and biophysical research communications

authors： Zheng Y,Ko TP,Yang Y,Shao W,Guo RT

更新日期：2015-01-16 00:00:00

abstract：:The small heat shock proteins are the ubiquitous proteins found in a wide range of organisms and function as molecular chaperones by binding to the folding intermediates of their substrates. Although the crystal structure of HSP16.5, a small heat shock protein from Methanococcus jannaschii, revealed that it is a hollo...

journal_title：Biochemical and biophysical research communications

authors： Kim DR,Lee I,Ha SC,Kim KK

更新日期：2003-08-08 00:00:00

abstract：:In order to evaluate the receptor subtypes of arginine vasopressin (AVP) in early proximal tubule (S1), outer medullary thick ascending limb of Henle's loop (MTAL) and collecting tubule (OMCT), the effect of AVP on intracellular free calcium ([Ca++]i) was determined using the fluorescence indicator Fura-2. Physiologic...

journal_title：Biochemical and biophysical research communications

authors： Jung KY,Endou H

更新日期：1991-10-15 00:00:00

abstract：INTRODUCTION:Reconstruction of respiratory epithelium is critical for the fabrication of bioengineered airway implants. Epithelial differentiation is typically achieved using bovine pituitary extract (BPE). Due to the xenogenic nature and undefined composition of BPE, an alternative for human clinical applications, dev...

journal_title：Biochemical and biophysical research communications

authors： Hintze JM,Tchoukalova YD,Sista R,Shah MK,Zhang N,Lott DG

更新日期：2018-09-18 00:00:00

abstract：:We have recently reported that synthetic peptide amides corresponding to regions of human FSH beta-subunit, hFSH-beta-(33-53) and hFSH-beta-(81-95), bind to receptor and stimulate estradiol biosynthesis by cultured rat Sertoli cells. Because of experimental difficulties caused by the presence of free sulfhydryl groups...

journal_title：Biochemical and biophysical research communications

authors： Grasso P,Crabb JW,Reichert LE Jr

更新日期：1993-01-15 00:00:00

abstract：UNLABELLED:Pervious biochemical and hemodynamic studies have highlighted the important role of εPKC in cardioprotection during ischemic preconditioning. However, little is known about the electrophysiological consequences of εPKC modulation in ischemic hearts. Membrane permeable peptide εPKC selective activator and inh...

journal_title：Biochemical and biophysical research communications

authors： Restivo M,Kozhevnikov DO,Qu YS,Yue Y,Mochly-Rosen D,El-Sherif N,Boutjdir M

更新日期：2012-09-21 00:00:00

abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

journal_title：Biochemical and biophysical research communications

authors： Kwiatkowska K,Sobota A

更新日期：1999-06-07 00:00:00

abstract：:Human epidermal melanocytes and keratinocytes express mRNA for all enzymes involved in de novo synthesis/recycling of the cofactor (6R) L-erythro 5,6,7,8 tetrahydrobiopterin (6BH4) in normal healthy individuals. An enhanced epidermal de novo synthesis was identified in association with decreased epidermal phenylalanin...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Zschiesche M,Moore J,Panske A,Hibberts NA,Herrmann FH,Metelmann HR,Sawatzki J

更新日期：1998-02-13 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the dise...

journal_title：Biochemical and biophysical research communications

authors： Gopalan A,Bhagavat R,Chandra N,Subbarao SH,Raja A,Bethunaickan R

更新日期：2018-02-12 00:00:00

abstract：:The amount of oxidative stress in severely traumatized patients is usually based on various individual parameters such as total antioxidants and lipid peroxidation. Serial measurements of plasma oxidation-reduction potential (ORP) in severely traumatized patients as a simple mean of assessing overall oxidative stress ...

journal_title：Biochemical and biophysical research communications

authors： Rael LT,Bar-Or R,Aumann RM,Slone DS,Mains CW,Bar-Or D

更新日期：2007-09-21 00:00:00

abstract：:Erythropoietin has been thought to be secreted to plasma soon after the production because of the difficulty of Western blot analysis and immunohistochemistry. We established the new methods of Western blot analysis and immunohistochemistry. Using the new methods, we investigated the effects of aldosterone and fludroc...

journal_title：Biochemical and biophysical research communications

authors： Yasuoka Y,Izumi Y,Nagai T,Fukuyama T,Nakayama Y,Inoue H,Horikawa K,Kimura M,Nanami M,Yanagita K,Oshima T,Yamazaki T,Uematsu T,Yamamura R,Kobayashi N,Shimada Y,Nagaba Y,Nakanishi T,Yamashita T,Mukoyama M,Sato Y,K

更新日期：2018-09-18 00:00:00

abstract：:The exon/intron organization and the structure of the 5' flanking region of the human thyrotropin receptor gene (hTSH-R) were determined. The hTSH-R gene spans more than 60 kb and is split into ten exons. The extracellular domain is encoded by the first nine exons and part of the last exon, whereas the transmembrane a...

journal_title：Biochemical and biophysical research communications

authors： Gross B,Misrahi M,Sar S,Milgrom E

更新日期：1991-06-14 00:00:00

abstract：:We found new photochemical intermediate of third rhodopsin-like pigment (tR) or slow cycling rhodopsin-like pigment (sR) in Halobacterium halobium, which was produced by simultaneous illumination with red and blue light. This illumination is employed for measurements of negative phototaxis. The formation of this inter...

journal_title：Biochemical and biophysical research communications

authors： Tomioka H,Kamo N,Takahashi T,Kobatake Y

更新日期：1984-09-28 00:00:00

abstract：:The platelet glycoprotein (GP) Ib/IX/V is a hetero-oligomeric receptor complex for von Willebrand factor (vWF) and mediates platelet adhesion and aggregation under high shear stress conditions. It is composed of alpha and beta chain of GP Ib, GP IX, AND and GP V. To establish transgenic mice carrying human GP Ib alpha...

journal_title：Biochemical and biophysical research communications

authors： Kitaguchi T,Murata M,Kuramochi T,Kobayashi K,Ito M,Ueyama Y,Nomura T,Hikichi K,Miyakawa Y,Handa M,Hiraoka Y,Aiso S,Ikeda Y

更新日期：1996-03-18 00:00:00

abstract：:Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phos...

journal_title：Biochemical and biophysical research communications

authors： Ducommun B,Draetta G,Young P,Beach D

更新日期：1990-02-28 00:00:00

abstract：:BA1544 from Bacillus anthracis was previously annotated as a transcription factor for the gene cluster ba1554 - ba1558, but has not been experimentally characterized. B. anthracis is an obligate pathogen causing fatal inhalational anthrax, and BA1544 is absolutely conserved in Bacillus species, including Bacillus cere...

journal_title：Biochemical and biophysical research communications

authors： Kim MI,Hong M

更新日期：2016-03-25 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterised by chronic inflammation of synovial tissue with aggressive proliferation of synovial cells causing destruction of cartilage and bone. Immunopathological mechanisms, infectious causes and genetic factors have been discussed, but the etiology of the disease has not been underst...

journal_title：Biochemical and biophysical research communications

authors： Mangasser-Stephan K,Dooley S,Welter C,Mutschler W,Hanselmann RG

更新日期：1997-05-08 00:00:00

abstract：:We investigated the effects of oxidative stress on mRNA levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and amphiregulin (AR) in rat gastric epithelial RGM1 cells. In response to stimulation with hydrogen peroxide (100-400 microM), gene expression of HB-EGF and AR increased in a dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki Y,Shinomura Y,Tsutsui S,Yasunaga Y,Zushi S,Higashiyama S,Taniguchi N,Matsuzawa Y

更新日期：1996-09-13 00:00:00

abstract：:Retroviral growth requires as an obligatory step the integration of a DNA copy of the viral RNA into the genomic DNA of the host. Recombinant human immunodeficiency virus type I (HIV-1) integrase (IN) expressed in Escherichia coli efficiently catalyzes the overall in vitro integration reaction, namely, the processing ...

journal_title：Biochemical and biophysical research communications

authors： Carteau S,Mouscadet JF,Goulaouic H,Subra F,Auclair C

更新日期：1993-05-14 00:00:00

abstract：:The α2-adrenoceptor inducer dexmedetomidine protects against acute lung injury (ALI), but the mechanism of this effect is largely unknown. The present study investigated the effect of dexmedetomidine on apoptosis induced by lipopolysaccharide (LPS) and the relationship between this effect and gap junction intercellula...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Tan X,Xue L

更新日期：2018-01-01 00:00:00

abstract：:Co-transcriptional RNA proofreading by RNA polymerase (RNAP) is essential for accurate mRNA synthesis and reactivation of stalled transcription complexes, which can otherwise compromise genome integrity. RNAP from the stress-resistant bacterium Deinococcus radiodurans exhibits high levels of RNA cleavage in comparison...

journal_title：Biochemical and biophysical research communications

authors： Esyunina D,Kulbachinskiy A

更新日期：2019-01-29 00:00:00

abstract：:Chromatin-associated high mobility group (HMG) proteins of the HMGB family are versatile architectural factors assisting various DNA-dependent processes such as transcription and recombination. Here, transgenic tobacco lines were generated that ectopically express the maize HMGB1 protein, as detected by immunoblot ana...

journal_title：Biochemical and biophysical research communications

authors： Lichota J,Ritt C,Grasser KD

更新日期：2004-05-21 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-BB elicits a migratory response including reorganization of the actin cytoskeleton in different cell types. Here we have investigated the effects of PDGF-BB stimulation on beta(1) integrin containing focal adhesions in human diploid fibroblasts adhered to collagen type I. Stimulat...

journal_title：Biochemical and biophysical research communications

authors： Ahlén K,Ring P,Tomasini-Johansson B,Holmqvist K,Magnusson KE,Rubin K

更新日期：2004-01-30 00:00:00