A novel vasopressin receptor in rat early proximal tubule.

abstract：:The rat pancreatic acinar cell line AR 4-2J is endowed with numerous PACAP type I receptors (PACAPR1). The cDNA of this receptor was PCR amplified at low stringency using two degenerate primers based on conserved sequences in the TM2 and TM6 segments of secretin, parathormone and calcitonin receptors. One additional a...

journal_title：Biochemical and biophysical research communications

authors： Svoboda M,Tastenoy M,Ciccarelli E,Stiévenart M,Christophe J

更新日期：1993-09-15 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

更新日期：2003-01-24 00:00:00

abstract：:Thioredoxin (TRX) is a ubiquitous dithiol-oxidoreduction enzyme broadly expressed in cells from prokaryote to eukaryote organisms. Human thioredoxin (human TRX) gene, previously cloned in our laboratory, codes for a 12-kDa protein found in the culture supernatant of several hemopoietic human cell lines. This protein i...

journal_title：Biochemical and biophysical research communications

authors： Wollman EE,Kahan A,Fradelizi D

更新日期：1997-01-23 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:To further extend the previous analysis of cis-acting elements and cognate trans-acting factors that contribute to GM-CSF transcriptional regulations, we have examined a promoter region between -1742 and -2010. DNase I footprinting assays showed four protected sequences named A, B, C and D. DNA transfections in the T-...

journal_title：Biochemical and biophysical research communications

authors： Musso M,Ghiorzo P,Fiorentini P,Giuffrida R,Ciotti P,Garré C,Ravazzolo R,Bianchi-Scarrà G

更新日期：1996-06-05 00:00:00

abstract：:Triple-negative breast cancer (TNBC) that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is a breast cancer subtype with very aggressive metastasis and poor prognosis. Unique cartilage matrix-associated protein (UCMA) is a vitamin K-dependent...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee YJ,Park SI,Kim JE

更新日期：2020-10-01 00:00:00

abstract：:Pulmonary hypertension associated with human immunodeficiency virus (HIV) infection also involves injury to the lung endothelium. However, the pathogenesis of HIV-induced pulmonary hypertension is not known; we hypothesized that HIV or secreted viral proteins could play a role in vascular injury and the increased freq...

journal_title：Biochemical and biophysical research communications

authors： Kanmogne GD,Primeaux C,Grammas P

更新日期：2005-08-12 00:00:00

abstract：:cDNA clones from Nicotiana plumbaginifolia have been isolated by hybridization to a yeast H+-ATPase gene. The largest one encodes a polypeptide (PMA2) of 956 amino acid residues which exhibits a homology of 73% with a limited protein sequence obtained from purified oat plasma membrane H+-ATPase (Schaller and Sussman, ...

journal_title：Biochemical and biophysical research communications

authors： Boutry M,Michelet B,Goffeau A

更新日期：1989-07-31 00:00:00

abstract：:Homeobox gene expression in osteoblast-like cells was investigated using the polymerase chain reaction (PCR). A total of 13 homeobox genes was detected in U-2 OS (human osteosarcoma) and MC3T3-E1 (mouse osteoblast) cells by sequencing cloned PCR products. Using specific primers, a different pattern of Hox gene express...

journal_title：Biochemical and biophysical research communications

authors： Kloen P,Visker MH,Olijve W,van Zoelen EJ,Boersma CJ

更新日期：1997-04-17 00:00:00

abstract：:SHPS-1 (SHP substrate-1) is a glycosylated receptor-like protein with three immunoglobulin-like domains in its extracellular region and four YXX(L/V/I) motifs, potential tyrosine phosphorylation and SRC homology 2 (SH2) domain binding sites, in its cytoplasmic region. Various mitogens and cell adhesion induce tyrosine...

journal_title：Biochemical and biophysical research communications

authors： Yamao T,Matozaki T,Amano K,Matsuda Y,Takahashi N,Ochi F,Fujioka Y,Kasuga M

更新日期：1997-02-03 00:00:00

abstract：:Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well ...

journal_title：Biochemical and biophysical research communications

authors： Mogilenko DA,Shavva VS,Dizhe EB,Orlov SV,Perevozchikov AP

更新日期：2010-11-19 00:00:00

abstract：:In this report we demonstrate formation of a triplex structure by an antiparallel RNA oligonucleotide corresponding to the 21 bp polypurine-pyrimidine stretch from -141 to -162 of the rat alpha 1(I) procollagen promoter with a Kd of 0.1-0.2 microM. The formation of triplexes by the triplex forming oligoribonucleotide ...

journal_title：Biochemical and biophysical research communications

authors： Ririe SS,Guntaka RV

更新日期：1998-08-10 00:00:00

abstract：:In mammals, behavioral and physiological processes display 24-h rhythms that are regulated by a circadian system. In the present study, we investigated the possibility that the expression of clock genes in peripheral leukocytes can be used to assess the circadian clock system. We found that Per1 and Per2 exhibit circa...

journal_title：Biochemical and biophysical research communications

authors： Fukuya H,Emoto N,Nonaka H,Yagita K,Okamura H,Yokoyama M

更新日期：2007-03-23 00:00:00

abstract：:Our previous report has shown that honokiol (HNK), a constituent of Magnolia officinalis, induces a novel form of non-apoptotic programmed cell death in human leukemia NB4 and K562 cells. In this study, we further explored the relationship between the cell death pathway and cytoplasmic vacuolization and studied the un...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Zhu X,Yang Z,Zhao X

更新日期：2013-01-18 00:00:00

abstract：:Exosomes, the natural vehicles of various biological molecules, have been examined in several research fields including drug delivery. Although understanding of the biological functions of exosomes has increased, how exosomes are transported between cells remains unclear. We hypothesized that cell tropism is important...

journal_title：Biochemical and biophysical research communications

authors： Toda Y,Takata K,Nakagawa Y,Kawakami H,Fujioka S,Kobayashi K,Hattori Y,Kitamura Y,Akaji K,Ashihara E

更新日期：2015-01-16 00:00:00

abstract：:The mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) gene and its 5'-flanking region was cloned from a 129 mouse ES bacteriophage P1 genomic library. The gene contains 7 exons and 6 introns and is 11.3 kb in length. The transcription initiation site was mapped at 35 bases upstream from the ATG star...

journal_title：Biochemical and biophysical research communications

authors： Matsuo M,Ensor CM,Tai HH

更新日期：1997-06-27 00:00:00

abstract：:The chaperonin from the acidothermophilic archaeon, Sulfolobus sp. Strain 7, is composed of two kinds of subunits designated as Scp alpha and Scp beta. In this study, we characterized the recombinant Scp alpha and Scp beta, which were separately expressed in Escherichia coli. Both of them were able to assemble to homo...

journal_title：Biochemical and biophysical research communications

authors： Yoshida T,Yohda M,Suzuki M,Yazaki K,Miura K,Endo I

更新日期：1998-01-26 00:00:00

abstract：:A neuropeptide was isolated from the corpora cardiaca of the corn earworm moth Heliothis zea, and purified by sequential gradient elution in three reversed phase-high performance liquid chromatographic steps. The primary structure, pGlu-Leu-Thr-Phe-Ser-Ser-Gly-Trp-Gly-Asn-NH2 was determined by automated gas-phase Edma...

journal_title：Biochemical and biophysical research communications

authors： Jaffe H,Raina AK,Riley CT,Fraser BA,Bird TG,Tseng CM,Zhang YS,Hayes DK

更新日期：1988-08-30 00:00:00

abstract：:Sensitization to Cupressaceae pollen has become one of the most important causes of pollinosis in Western countries during winter and early spring. However, the characterization of the extracts, the allergens involved and the cross-reactivity with other pollen sources still remain poorly studied; in the case of Cupres...

journal_title：Biochemical and biophysical research communications

authors： Pico de Coaña Y,Parody N,Fuertes MÁ,Carnés J,Roncarolo D,Ariano R,Sastre J,Mistrello G,Alonso C

更新日期：2010-10-22 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine involved in apoptotic cell death, cellular proliferation, differentiation, inflammation, and tumorigenesis. In tumors it is secreted by tumor associated macrophages and can have both pro- and anti-tumorigenic effects. To identify genes regulated by TNFal...

journal_title：Biochemical and biophysical research communications

authors： Guardiola-Serrano F,Haendeler J,Lukosz M,Sturm K,Melchner Hv,Altschmied J

更新日期：2008-11-28 00:00:00

abstract：:Porphyromonas gingivalis acquires heme through an outer-membrane heme transporter HmuR and heme-binding hemophore-like lipoprotein HmuY. Here, we compare binding of iron(III) mesoporphyrin IX (mesoheme) and iron(III) deuteroporphyrin IX (deuteroheme) to HmuY with that of iron(III) protoporphyrin IX (protoheme) and pro...

journal_title：Biochemical and biophysical research communications

authors： Wojaczyński J,Wójtowicz H,Bielecki M,Olczak M,Smalley JW,Latos-Grażyński L,Olczak T

更新日期：2011-07-29 00:00:00

abstract：:TRAIP/RNF206 plays diverse roles in cell cycle progression, DNA damage response, and DNA repair pathways. Physiological importance of TRAIP is highlighted by the identification of pathogenic mutations of TRAIP gene in patients diagnosed with primordial dwarfism. Although the diverse functions of TRAIP in the nucleus h...

journal_title：Biochemical and biophysical research communications

authors： Park IS,Han Yg,Chung HJ,Jung YW,Kim Y,Kim H

更新日期：2016-02-19 00:00:00

abstract：:The effect of vitamin A on the expression of apoAI and CIII genes in intact rats was studied. In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA). A similar administration to normal rats caused an increase in the apoAI mRNA level...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki A,Kikuchi T,Kurata K,Masushige S,Hasegawa T,Kato S

更新日期：1994-12-30 00:00:00

abstract：:Betaine Aldehyde Dehydrogenase (betaine aldehyde: NAD(P)+ oxidoreductase, (E.C. 1.2.1.8; BADH) catalyze the irreversible oxidation of betaine aldehyde (BA) to glycine betaine (GB) and is essential for polyamine catabolism, γ-aminobutyric acid synthesis, and carnitine biosynthesis. GB is an important osmolyte that regu...

journal_title：Biochemical and biophysical research communications

authors： Rosas-Rodríguez JA,Soñanez-Organis JG,Godoy-Lugo JA,Espinoza-Salazar JA,López-Jacobo CJ,Stephens-Camacho NA,González-Ochoa G

更新日期：2017-08-26 00:00:00

abstract：:Parkin mutations are responsible for the pathogenesis of autosomal-recessive juvenile parkinsonism (AR-JP). On initial screening of Japanese patients with AR-JP, we had found that approximately half of the parkin mutations are deletions occurring between exons 2 and 5, forming a deletion hot spot. In this study, we in...

journal_title：Biochemical and biophysical research communications

authors： Asakawa S,Hattori N,Shimizu A,Shimizu Y,Minoshima S,Mizuno Y,Shimizu N

更新日期：2009-11-06 00:00:00

abstract：:Tetrahymena p85 is localized to the presumptive division plane before division furrow formation; its molecular weight in SDS-polyacrylamide gel electrophoresis differs in wild-type and temperature-sensitive cell-division-arrest mutant cdaA1 cells. At the restrictive temperature, p85 localization and division furrow fo...

journal_title：Biochemical and biophysical research communications

authors： Gonda K,Nishibori K,Ohba H,Watanabe A,Numata O

更新日期：1999-10-14 00:00:00

abstract：:We have identified and characterized the novel human transmembrane protein 9 (TMEM9). TMEM9 encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites, and three conserved cys-rich domains in the N-terminus, but no hitherto known fu...

journal_title：Biochemical and biophysical research communications

authors： Kveine M,Tenstad E,Døsen G,Funderud S,Rian E

更新日期：2002-10-04 00:00:00

abstract：:Autophagy is a tightly regulated self-digestion system. As in other cell types, autophagy plays an essential role in the homeostasis of pancreatic beta cells. However, the mechanisms involved in the deterioration of beta cell function caused by autophagic failure have not yet been fully elucidated. To gain insight int...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto E,Uchida T,Abe H,Taka H,Fujimura T,Komiya K,Hara A,Ogihara T,Fujitani Y,Ueno T,Takeda S,Watada H

更新日期：2014-10-10 00:00:00

abstract：:The appearance of Fas receptor at the surface of pancreatic beta-cells affected by progressive insulitis strongly suggests that Fas-mediated beta-cell apoptosis plays an important role in the pathogenesis of type 1 diabetes. In support of this concept, the present study has shown that islet cells from NOD mice and the...

journal_title：Biochemical and biophysical research communications

authors： Augstein P,Dunger A,Salzsieder C,Heinke P,Kubernath R,Bahr J,Fischer U,Rettig R,Salzsieder E

更新日期：2002-01-11 00:00:00

abstract：:Genome editing technology using programmable nucleases has rapidly evolved in recent years. The primary mechanism to achieve precise integration of a transgene is mainly based on homology-directed repair (HDR). However, an HDR-based genome-editing approach is less efficient than non-homologous end-joining (NHEJ). Rece...

journal_title：Biochemical and biophysical research communications

authors： Shin JH,Jung S,Ramakrishna S,Kim HH,Lee J

更新日期：2018-07-07 00:00:00