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Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration.

Abstract：

:Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine involved in apoptotic cell death, cellular proliferation, differentiation, inflammation, and tumorigenesis. In tumors it is secreted by tumor associated macrophages and can have both pro- and anti-tumorigenic effects. To identify genes regulated by TNFalpha, we performed a gene trap screen in the mammary carcinoma cell line MCF-7 and recovered 64 unique, TNFalpha-induced gene trap integration sites. Among these were the genes coding for the zinc finger protein ZC3H10 and for the transcription factor grainyhead-like 3 (GRHL3). In line with the dual effects of TNFalpha on tumorigenesis, we found that ZC3H10 inhibits anchorage independent growth in soft agar suggesting a tumor suppressor function, whereas GRHL3 strongly stimulated the migration of endothelial cells which is consistent with an angiogenic, pro-tumorigenic function.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Guardiola-Serrano F,Haendeler J,Lukosz M,Sturm K,Melchner Hv,Altschmied J

doi

10.1016/j.bbrc.2008.09.070

subject

Has Abstract

pub_date

2008-11-28 00:00:00

pages

748-52

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01827-5

journal_volume

376

pub_type

杂志文章

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