Endogenous nitric oxide modulates endothelin-1 induced contraction of bovine oviduct.

abstract：:We isolated genomic DNA containing the entire sequence of ZF5, which was originally identified by its ability to repress the mouse c-myc promoter and which was characterized as one of the POZ (Poxvirus and zinc finger) proteins. The POZ motif is a protein-protein interaction interface found at the N-terminal region of...

journal_title：Biochemical and biophysical research communications

authors： Yokoro K,Yanagidani A,Obata T,Yamamoto S,Numoto M

更新日期：1998-05-29 00:00:00

abstract：:Using isolated liver mitochondria we show that low concentrations of TBT (0.5 microM) cause the release of mitochondrial cytochrome c, in the presence of Ca(2+). This is reflected in a rapid loss of membrane potential (DeltaPsi(m)), and a large-amplitude swelling characteristic of mitochondrial permeability transition...

journal_title：Biochemical and biophysical research communications

authors： Gogvadze V,Stridh H,Orrenius S,Cotgreave I

更新日期：2002-04-12 00:00:00

abstract：:Possible mediators of descending inhibition in the rat proximal colon were studied. Localized distension with a small balloon caused relaxation of the circular muscle on the anal side of the distended region. This relaxation was still observed after the colonic segment had been desensitized to ATP, neurotensin and vas...

journal_title：Biochemical and biophysical research communications

authors： Hata F,Ishii T,Kanada A,Yamano N,Kataoka T,Takeuchi T,Yagasaki O

更新日期：1990-11-15 00:00:00

abstract：:The forced expression of the catalytic subunit of human telomerase, hTERT, produces telomerase activity, allows telomere maintenance, and extends the cellular life span of IMR90 human lung fibroblasts. The mutation D869A abolishes both the catalytic activity of hTERT and its ability to extend cellular life span, demon...

journal_title：Biochemical and biophysical research communications

authors： Ouellette MM,Aisner DL,Savre-Train I,Wright WE,Shay JW

更新日期：1999-01-27 00:00:00

abstract：:In vivo gluconeogenesis from (3-13 C)alanine was evident in terminal instar Manduca sexta larvae from the selective fractional 13C enrichment in trehalose, a disaccharide of glucose and the major blood sugar of insects. De novo glucose synthesis was observed in insects fed a low carbohydrate diet for 1 or more days. G...

journal_title：Biochemical and biophysical research communications

authors： Thompson SN

更新日期：1997-08-28 00:00:00

abstract：:Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baica...

journal_title：Biochemical and biophysical research communications

authors： Xiao T,Cui Y,Ji H,Yan L,Pei D,Qu S

更新日期：2021-01-01 00:00:00

abstract：:In addition to the well established cyclooxygenase pathway, cultured aortic smooth muscle cells convert arachidonic acid to several polar metabolites identified by high performance liquid chromatography and gaz chromatography-mass spectrometry. 15-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid and 5-Hyd...

journal_title：Biochemical and biophysical research communications

authors： Larrue J,Rigaud M,Razaka G,Daret D,Demond-Henri J,Bricaud H

更新日期：1983-04-15 00:00:00

abstract：:The outward K+ current induced by step depolarization of freshly dispersed myocytes of guinea-pig taenia coli decreased about 80% upon treatment with 3 mM tetraethylammonium chloride (TEA). Isoproterenol (ISO, 2-5 microM) restored it to a large extent. This restoration did not occur in the presence of propranolol (2 m...

journal_title：Biochemical and biophysical research communications

authors： Fan SF,Wang S,Kao CY

更新日期：1994-05-30 00:00:00

abstract：:Nuclear magnetic resonance (NMR) data directly indicated a Ca2+-dependent interaction between calmodulin (CaM) and CoDN3, a small effector of the plant pathogenic fungus Colletotrichum orbiculare, which is the causal agent of cucumber anthracnose. The overall conformation of CoDN3 is intrinsically disordered, and the ...

journal_title：Biochemical and biophysical research communications

authors： Isozumi N,Inoue Y,Imamura T,Mori M,Takano Y,Ohki S

更新日期：2019-06-30 00:00:00

abstract：:Prostaglandin (PG)E(2) is a critical lipid mediator connecting chronic inflammation to cancer. The anti-carcinogenic epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) suppresses cellular PGE(2) biosynthesis, but the underlying molecular mechanisms are unclear. Here, we investigated the interference ...

journal_title：Biochemical and biophysical research communications

authors： Koeberle A,Bauer J,Verhoff M,Hoffmann M,Northoff H,Werz O

更新日期：2009-10-16 00:00:00

abstract：:Inhibitors of serine/threonine protein phosphatases can inhibit apoptosis. We investigated which protein phosphatases are critical for this protection using calyculin A, okadaic acid, and tautomycin. All three phosphatase inhibitors prevented anisomycin-induced apoptosis in leukemia cell models. In vitro, calyculin A ...

journal_title：Biochemical and biophysical research communications

authors： Chatfield K,Eastman A

更新日期：2004-10-29 00:00:00

abstract：:Each chromosome occupies its own-specific space called a 'territory' within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CTs, however, remains unknown. On the other hand, dioxin is known to be ...

journal_title：Biochemical and biophysical research communications

authors： Oikawa K,Yoshida K,Takanashi M,Tanabe H,Kiyuna T,Ogura M,Saito A,Umezawa A,Kuroda M

更新日期：2008-09-19 00:00:00

abstract：:We have characterized the genomic structure of the mouse Zfp148 gene encoding Beta-Enolase Repressor Factor-1 (BERF-1), a Kruppel-like zinc finger protein involved in the transcriptional regulation of several genes, which is also termed ZBP-89, BFCOL1. The cloned Zfp148 gene spans 110 kb of genomic DNA encompassing th...

journal_title：Biochemical and biophysical research communications

authors： Feo S,Antona V,Cammarata G,Cavaleri F,Passantino R,Rubino P,Giallongo A

更新日期：2001-04-27 00:00:00

abstract：:Aberrantly expressed microRNAs (miRNAs) are frequently associated with the aggressive malignant behavior of human cancers, including clear cell renal cell carcinoma (ccRCC). Based on the preliminary deep sequencing data, we hypothesized that miR-187 may play an important role in ccRCC development. In this study, we fo...

journal_title：Biochemical and biophysical research communications

authors： Zhao J,Lei T,Xu C,Li H,Ma W,Yang Y,Fan S,Liu Y

更新日期：2013-08-23 00:00:00

abstract：:Ectopic over-expression of nucleophosmin/B23 caused a marked up-regulation in the amounts of Yin Yang 1 (YY1) and proliferating cellular nuclear antigen (PCNA) proteins. Transfection with nucleophosmin/B23-targeting siRNA induced a decrease in the intracellular amounts of nucleophosmin/B23, YY1, and PCNA. PCNA express...

journal_title：Biochemical and biophysical research communications

authors： Weng JJ,Yung BY

更新日期：2005-09-30 00:00:00

abstract：:Cultured endothelial cells release a potent vasoconstrictor peptide, endothelin. Cumulative addition of synthetic endothelin to isolated rabbit aortic rings elicited a concentration-dependent increase in contractile tension which was endothelium-independent. In cultured rabbit vascular smooth muscle cells loaded with ...

journal_title：Biochemical and biophysical research communications

authors： Marsden PA,Danthuluri NR,Brenner BM,Ballermann BJ,Brock TA

更新日期：1989-01-16 00:00:00

abstract：:Oxidative stress is involved in a multitude of pathological conditions. In the present study, cell cycle arrest was demonstrated in monolayer cultures of Chinese hamster ovary cells subjected to low-level oxidative stress induced by the addition of hydrogen peroxide. Fluorescence-activated cell sorting analysis charac...

journal_title：Biochemical and biophysical research communications

authors： Clopton DA,Saltman P

更新日期：1995-05-05 00:00:00

abstract：:A failure of bone marrow mesenchymal stem cells (BM-MSCs) to adhere to hematopoietic cells is an essential cause of the progression of chronic myelogenous leukemia and is also a cause of failure of bone marrow (BM) transplantation, but the exact mechanisms of this have not been fully elucidated. Recent studies have in...

journal_title：Biochemical and biophysical research communications

authors： Jiang YH,Liu J,Lin J,Li SQ,Xu YM,Min QH,Zhong QH,Sun F,Li J,You XH,Liao KL,Qin TY,Zhao C,Huang B,Wang XZ

更新日期：2020-01-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of cardiovascular diseases and are modified in response to a variety of stimuli such as bioactive peptides, cytokines and/or grown factors. In this study, we demonstrated that angiotensin II (Ang II) induces a time- and dose-dependent increase...

journal_title：Biochemical and biophysical research communications

authors： Jiménez E,Pérez de la Blanca E,Urso L,González I,Salas J,Montiel M

更新日期：2009-03-20 00:00:00

abstract：:The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M ...

journal_title：Biochemical and biophysical research communications

authors： Obana K,Naruse M,Inagami T,Brown AB,Naruse K,Kurimoto F,Sakurai H,Demura H,Shizume K

更新日期：1985-11-15 00:00:00

abstract：:Glycated insulin was evaluated in plasma and biological tissues of diabetic animal models by immunocytochemistry (ICC) and a novel radioimmunoassay. Glycated insulin circulated at 0.10 +/- 0.04 ng/ml and 2.20 +/- 0.14 ng/ml in lean and diabetic obese (ob/ob) mice, corresponding to 12.5 and 9.8% total plasma insulin, r...

journal_title：Biochemical and biophysical research communications

authors： McKillop AM,Mooney MH,Harriott P,Flatt PR,O'Harte FP

更新日期：2001-08-24 00:00:00

abstract：:The effects of insulin on the steady-state level of human insulin receptor (hIR) mRNA were examined in the HepG2 human liver cell line using Northern blot analysis of either total cellular or poly(A)+ RNA. In control cells, up to six (4.5, 5.2, 7.4, 8.5, 9.4 and 10.8 kb) hybridizable species of hIR mRNA were identifie...

journal_title：Biochemical and biophysical research communications

authors： Rohilla AM,Anderson C,Wood WM,Berhanu P

更新日期：1991-03-15 00:00:00

abstract：:Calmodulin (CaM) was reported to interact with PreIQ and IQ of CaV1.2 channels, but to date, no explicit binding sites of CaM were illustrated. Therefore, in the present study, we firstly used MOE (Molecular Operating Environment) for protein-protein docking and we found that the most likely residues of CaM that play ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Yan S,Chen S,Zhang J,Shen Y,Su J,He G,Feng R,Shao D,Hao L

更新日期：2020-05-21 00:00:00

abstract：:A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical. ...

journal_title：Biochemical and biophysical research communications

authors： Reichelt KL,Elgjo K,Edminson PD

更新日期：1987-08-14 00:00:00

abstract：:Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of drug stimuli. Here, we demonstrated that arsenic trioxide inhibited the proliferation of gallbladder carcinoma in vivo and in vitro as well as the transcription of cell cycle-related protein Cyclin D1. And,...

journal_title：Biochemical and biophysical research communications

authors： Ai Z,Lu W,Ton S,Liu H,Sou T,Shen Z,Qin X

更新日期：2007-08-31 00:00:00

abstract：:The control of HIV-1 gene expression depends upon interaction of Tat with the trans-activation responsive (TAR) element present at the 5' end of all HIV-1 transcripts. The TAR sequence forms a stable hair-pin structure that binds Tat and several cellular factors in vitro. In the absence of Tat, TAR acts as a transcrip...

journal_title：Biochemical and biophysical research communications

authors： Kaczmarski W,Khan SA

更新日期：1993-10-29 00:00:00

abstract：:Endogenous cysteine proteases were given much attention lately, as their role in a variety of pathophysiological disorders became evident. Amongst them cathepsins, which are thought to be implicated in mediation of osteoporosis, cancer progression, atherosclerosis, and many other conditions, are of considerable intere...

journal_title：Biochemical and biophysical research communications

authors： Bratkovic T,Lunder M,Popovic T,Kreft S,Turk B,Strukelj B,Urleb U

更新日期：2005-07-08 00:00:00

abstract：:A bovine brain calmodulin-dependent protein kinase undergoes autophosphorylation with a maximal incorporation of 10 mol phosphate per mol enzyme. The autophosphorylated enzyme is fully active, independent of Ca2+ and calmodulin. Although the autophosphorylation reaction depends on Ca2+ and calmodulin, it can be render...

journal_title：Biochemical and biophysical research communications

authors： Zhang GY,Wang JH,Sharma RK

更新日期：1993-03-15 00:00:00

abstract：:The serotonin(1A) (5-HT(1A)) receptor is an important member of the superfamily of seven transmembrane domain G-protein-coupled receptors. We report here that solubilization of the hippocampal 5-HT(1A) receptor by the zwitterionic detergent CHAPS is accompanied by loss of membrane cholesterol which results in a reduct...

journal_title：Biochemical and biophysical research communications

authors： Chattopadhyay A,Jafurulla M,Kalipatnapu S,Pucadyil TJ,Harikumar KG

更新日期：2005-02-25 00:00:00

abstract：:Neocarzinostatin is a radiomimetic antibiotic with a potent cytotoxic effect which elicits a hypersensitive response in human cells homozygous or heterozygous for the gene for ataxia-telangiectasia. The extent and the time course of potentially lethal damage repair and sublethal damage repair following neocarzinostati...

journal_title：Biochemical and biophysical research communications

authors： Shiloh Y,Tabor E,Becker Y

更新日期：1983-01-27 00:00:00