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Identification of an interleukin-6 responsive element and characterization of the proximal promoter region of the rat hemopexin gene.

Abstract：

:The rat hemopexin (Hx) gene was isolated and studies of its transcriptional regulation initiated. For analysis by a transient expression assay, the sequence between -2400 and +21 and sequential 5' truncates were linked to the chloramphenicol acetyltransferase (CAT) gene. HepG2 cells transfected with these CAT constructs were treated with conditioned medium of lipopolysaccharide stimulated human monocytes, interleukin-1 (IL-1) or interleukin-6 (IL-6). The activities of putative regulatory regions joined to the SV40 promoter indicated that the flanking region of the rat Hx gene from -209 to -104 contains three functional regions designated proximal regulatory regions; PRR-I (-209 to -173), -II (-178 to -158) and -III (-154 to -104). We found that PRR-II contains a different class of IL-6 responsive element (RE) from that reported for the human Hx gene, and that PRR-I and PRR-III participate in the basal expression of rat Hx in HepG2 cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagae Y,Muller-Eberhard U

doi

10.1016/s0006-291x(05)81002-2

subject

Has Abstract

pub_date

1992-05-29 00:00:00

pages

420-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81002-2

journal_volume

185

pub_type

杂志文章

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