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Structural basis of SH2 domain mutations in X-linked agammaglobulinemia.

Abstract：

:The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide binding site. The model was used to predict the recognition sequence of the target protein, which probably is YEXI/L. Mutations in the Btk sequence can cause the human disease X-linked agammaglobulinemia and reasons for the disease in Btk SH2 mutations were inferred from the model.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Vihinen M,Nilsson L,Smith CI

doi

10.1006/bbrc.1994.2802

subject

Has Abstract

pub_date

1994-12-15 00:00:00

pages

1270-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)72802-6

journal_volume

205

pub_type

杂志文章

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