BST-2 is a potential activator of invasion and migration in tamoxifen-resistant breast cancer cells.

abstract：:Normal human serum transferrin is present in several isoforms, due to differences in glycosylation. Transferrin has two potential glycosylation sites, both normally occupied by oligosaccharide chains. Two of the transferrin isoforms, called carbohydrate deficient transferrin, are specifically increased in patients wit...

journal_title：Biochemical and biophysical research communications

authors： Landberg E,Påhlsson P,Lundblad A,Arnetorp A,Jeppsson JO

更新日期：1995-05-16 00:00:00

abstract：:Phage displayed peptide library was used to select tumor necrosis factor alpha (TNFalpha) binding peptides. After three sequential rounds of biopanning, some linear TNFalpha-binding peptides were identified from a 12-mer peptide library. A consensus sequence (L/M)HEL(Y/F)(L/M)X(W/Y/F), where X might be variable residu...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zheng L,Zhao A,Gao B,Liu NL,Wang F,Dong J,Xin ZT,Shao NS,Wang HX,Xue YN

更新日期：2003-10-31 00:00:00

abstract：:The cell adhesion molecule integrin alphaMbeta2 associates with the urokinase-type plasminogen activator receptor (uPAR) on monocytes and neutrophils. uPAR also associates with members of the beta1 and beta3 integrins, and it modulates the ligand-binding function of these integrins. In this study, we showed that co-ex...

journal_title：Biochemical and biophysical research communications

authors： Tang ML,Kong LS,Law SK,Tan SM

更新日期：2006-09-29 00:00:00

abstract：:In an attempt to enhance the immunological efficacy of genetic immunization, we investigated a new biological means for delivering antigen gene directly to the cytoplasm via membrane fusion. In this context, we investigated fusogenic liposome (FL) encapsulating DNA as a possible genetic immunization vehicle. RT-PCR an...

journal_title：Biochemical and biophysical research communications

authors： Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Shimokawa M,Sugita T,Niwa T,Oda A,Akashi M,Tsutsumi Y,Mayumi T,Nakagawa S

更新日期：2004-12-10 00:00:00

abstract：:Mechanical loading of cultured mesangial cells has been shown to induce both increased production of matrix proteins and cell proliferation. This in vitro phenomenon has been implicated in the progression of glomerular sclerosis observed in a variety of glomerular diseases. However, it is not yet known how cells sense...

journal_title：Biochemical and biophysical research communications

authors： Hamasaki K,Mimura T,Furuya H,Morino N,Yamazaki T,Komuro I,Yazaki Y,Nojima Y

更新日期：1995-07-17 00:00:00

abstract：:The main transport mechanism of reabsorption of sodium bicarbonate and fluid in the renal proximal tubules involves Na(+)/H(+) exchanger 3 (NHE3), which is acutely and chronically downregulated by parathyroid hormone (PTH). Although PTH is known to exert an inhibitory effect on NHE3 expression and transcription, the m...

journal_title：Biochemical and biophysical research communications

authors： Neri EA,Bezerra CN,Queiroz-Leite GD,Polidoro JZ,Rebouças NA

更新日期：2015-06-12 00:00:00

abstract：:Autophagy is the bulk degradation of cytosolic materials in lysosomes/vacuoles of eukaryotic cells. In the yeast Saccharomyces cerevisiae, 17 Atg proteins are known to be involved in autophagosome formation. Genome wide analyses have shown that Atg17 interacts with numerous proteins. Further studies on these interacti...

journal_title：Biochemical and biophysical research communications

authors： Kabeya Y,Kawamata T,Suzuki K,Ohsumi Y

更新日期：2007-05-04 00:00:00

abstract：:The protease, cancer procoagulant, was isolated from three murine metastatic tumors and was purified to apparent homogeneity (SDS-PAGE) from Lewis lung cells by the sequence of (NH4)2SO4 precipitation, DE-53 anion-exchange chromatography, and Sephacryl 200 chromatography. The murine tumor enzyme has a molecular weight...

journal_title：Biochemical and biophysical research communications

authors： Moore WR

更新日期：1992-04-30 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is a cytokine, which inhibits angiogenesis and decreases endothelial cell proliferation and migration, suggesting that LIF may modulate vascular tone. In this study, we examined the effects of LIF on the tone of rat arteries. The isometric tension of ring preparations from rat superior...

journal_title：Biochemical and biophysical research communications

authors： Kimura K,Tsuda K,Moriwaki C,Kawabe T,Hamada M,Obana M,Baba A,Hano T,Nishio I

更新日期：2002-06-07 00:00:00

abstract：:A dose-dependent increase in cholesterol absorption was induced by glucose addition (0-75 mM) to the apical medium of TC7 cells, a well-characterized clone of Caco-2. The uptake into the cells and the secretion rate to the basolateral space were both enhanced by glucose and galactose. This up-regulation was suppressed...

journal_title：Biochemical and biophysical research communications

authors： Play B,Salvini S,Haikal Z,Charbonnier M,Harbis A,Roussel M,Lairon D,Jourdheuil-Rahmani D

更新日期：2003-10-17 00:00:00

abstract：:Apoptosis is a well defined physiological process characterised by many specific features including DNA fragmentation and protease activation. Cell membrane-associated changes such as the altered exposure of phosphatidylserine and glycosylation patterns have also been described. We investigate here the change in expos...

journal_title：Biochemical and biophysical research communications

authors： Russell L,Waring P,Beaver JP

更新日期：1998-09-18 00:00:00

abstract：:In this study, we examined the effect of CLA isomers in preventing age-associated muscle loss and the mechanisms underlying this effect, using 12-months-old C57BL/6 mice fed 10% corn oil (CO) or a diet supplemented with 0.5% c9t11-CLA, t10c12-CLA, or c9t11-CLA+t10c12-CLA (CLA-mix) for 6months. Both t10c12-CLA and CLA-...

journal_title：Biochemical and biophysical research communications

authors： Rahman M,Halade GV,El Jamali A,Fernandes G

更新日期：2009-06-12 00:00:00

abstract：:Glycerol-3-phosphate acyltransferase, mitochondrial (GPAM) is a rate-limiting enzyme catalyzing triglyceride synthesis. Recently, we demonstrated that the anti-viral drug ribavirin (RBV) reduces GPAM expression by downregulating CCAAT/enhancer-binding protein α (C/EBPα). However, the precise mechanisms of GPAM suppres...

journal_title：Biochemical and biophysical research communications

authors： Onomura D,Satoh S,Ueda Y,Dansako H,Kato N

更新日期：2020-11-26 00:00:00

abstract：:Biochemical properties of Type II restriction enzyme BanI were characterized. Kinetic parameters were evaluated and an enhancement of rate was observed when the recognition site was located in a more central position in the substrate, suggesting that BanI locates its recognition site by a sliding mechanism. As BanI ha...

journal_title：Biochemical and biophysical research communications

authors： Advani S,Roy KB

更新日期：2000-12-09 00:00:00

abstract：:Integrins alpha(M)beta(2) plays important role on leukocytes, such as adhesion, migration, phagocytosis, and apoptosis. It was hypothesized that homomeric associations of integrin subunits provide a driving force for integrins activation, and simultaneously inducing the formation of integrins clusters. However, experi...

journal_title：Biochemical and biophysical research communications

authors： Fu G,Wang C,Wang GY,Chen YZ,He C,Xu ZZ

更新日期：2006-12-29 00:00:00

abstract：:While mutation of alpha-synuclein is a cause of autosomal-dominant Parkinson's disease (PD), it is still elusive as to how alpha-synuclein is involved in the pathogenesis of PD. Here, we show that dopamine-dependent accumulation of alpha-synuclein in cultured cells results in apoptosis. Furthermore, activation of insu...

journal_title：Biochemical and biophysical research communications

authors： Kao SY

更新日期：2009-07-31 00:00:00

abstract：:This study tests the hypothesis that articular chondrocytes shift from a characteristically glycolytic to an oxidative energy metabolism during population expansion in monolayer. Bovine articular chondrocytes were cultured in monolayer under standard incubator conditions for up to 14 days. Cellular proliferation, oxyg...

journal_title：Biochemical and biophysical research communications

authors： Heywood HK,Lee DA

更新日期：2008-08-22 00:00:00

abstract：:Familial ATTR amyloidosis is caused by point mutations in the transthyretin gene. The clinical manifestations are highly varied but polyneuropathy and/or cardiomyopathy are generally the main symptoms. The amyloid fibrils can either be composed of only intact ATTR molecules or intact together with fragmented ATTR spec...

journal_title：Biochemical and biophysical research communications

authors： Ihse E,Stangou AJ,Heaton ND,O'Grady J,Ybo A,Hellman U,Edvinsson A,Westermark P

更新日期：2009-02-20 00:00:00

abstract：:To better understand the mechanism of interactions between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 potentially important for receptor-ligand...

journal_title：Biochemical and biophysical research communications

authors： Mazna P,Berka K,Jelinkova I,Balik A,Svoboda P,Obsilova V,Obsil T,Teisinger J

更新日期：2005-07-08 00:00:00

abstract：:Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a sign...

journal_title：Biochemical and biophysical research communications

authors： Bazan JF

更新日期：1989-10-31 00:00:00

abstract：:As part of an effort to identify genes potentially involved in the Down Syndrome pathogenesis, in this paper we report the identification and characterization of a new human gene (named SH3BGRL), which shows a high homology to the SH3BGR gene, previously mapped to the Down Syndrome region of chromosome 21. The SH3BGRL...

journal_title：Biochemical and biophysical research communications

authors： Egeo A,Mazzocco M,Arrigo P,Vidal-Taboada JM,Oliva R,Pirola B,Giglio S,Rasore-Quartino A,Scartezzini P

更新日期：1998-06-18 00:00:00

abstract：:Multidrug resistance in human tumour cells is often associated with increased expression of the 190kDa multidrug resistance protein, MRP1, that belongs to the ATP-binding cassette superfamily of transport proteins. MRP1 is also an efficient transporter of many organic anions. In the present study, we have mapped the e...

journal_title：Biochemical and biophysical research communications

authors： Koike K,Deeley RG,Cole SP

更新日期：2004-03-12 00:00:00

abstract：:The E. coli ogt O6-alkylguanine-DNA alkyltransferase has two cysteine residues positioned identically with respect to cysteines in the E. coli ada O6-alkylguanine-DNA alkyltransferase. In order to assess their function, these residues were each substituted by a glycine to generate altered forms of the ogt protein. Mut...

journal_title：Biochemical and biophysical research communications

authors： Harris LC,Potter PM,Margison GP

更新日期：1992-08-31 00:00:00

abstract：:Calcium is a key signaling molecule and ion involved in a variety of diverse processes in our central nervous system (CNS) which include gene expression, synaptic transmission and plasticity, neuronal excitability and cell maintenance. Proper control of calcium signaling is not only vital for neuronal physiology but a...

journal_title：Biochemical and biophysical research communications

authors： Mark MD,Schwitalla JC,Groemmke M,Herlitze S

更新日期：2017-02-19 00:00:00

abstract：:Here we have investigated the function of TcRho1, a Rho family orthologue from the parasite Trypanosoma cruzi. We have selected parasites overexpressing wild-type TcRho1 and a truncated form of TcRho1 (TcRho1-DeltaCaaX) which is unable to undergo farnesylation and supposed to interfere with recruitment of Rho effector...

journal_title：Biochemical and biophysical research communications

authors： de Melo LD,Nepomuceno-Silva JL,Sant'Anna C,Eisele N,Ferraro RB,Meyer-Fernandes JR,de Souza W,Cunha-e-Silva NL,Lopes UG

更新日期：2004-10-22 00:00:00

abstract：:Human endothelial cell thrombin receptors were functionally expressed in Xenopus laevis oocytes by injection of RNA extracted from human umbilical vein endothelial cells. Oocytes injected with endothelial cell RNA responded to thrombin with a Ca2(+)-dependent depolarizing current whose size depended on the amount of R...

journal_title：Biochemical and biophysical research communications

authors： Pipili-Synetos E,Gershengorn MC,Jaffe EA

更新日期：1990-09-28 00:00:00

abstract：:Fragments of the human glutathione S-transferase pi gene and 15 kb of its 5' flanking region have been fused to the chloramphenicol acetyl transferase (CAT) reporter gene. Transfection into a number of human cell lines (Hela, HepG2, MCF7 and EJ) has demonstrated that the AP1 binding site, located between nucleotides -...

journal_title：Biochemical and biophysical research communications

authors： Xia CL,Cowell IG,Dixon KH,Pemble SE,Ketterer B,Taylor JB

更新日期：1991-04-15 00:00:00

abstract：:Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewid...

journal_title：Biochemical and biophysical research communications

authors： Mao XQ,Kawai M,Yamashita T,Enomoto T,Dake Y,Sasaki S,Kataoka Y,Fukuzumi T,Endo K,Sano H,Aoki T,Kurimoto F,Adra CN,Shirakawa T,Hopkin JM

更新日期：2000-09-24 00:00:00

abstract：:Fifteen luciferase plasmid constructs driven by various promoters including cytomegalovirus (CMV), Rous sarcoma virus (RSV), human serum albumin (SA), alpha-1 antitrypsin (AAT), cytochrome P450 CYP1A2, CYP2C9, CYP2C18, CYP2D6, CYP3A4, mouse CYP2b10, human amyloid precursor protein (APP), chicken beta actin (ACT), nucl...

journal_title：Biochemical and biophysical research communications

authors： Al-Dosari M,Zhang G,Knapp JE,Liu D

更新日期：2006-01-13 00:00:00

abstract：:Biochemical studies revealed that the novel rice plant-specific kinesin K16 has several unique enzymatic characteristics as compared to conventional kinesins. The ADP-free form of K16 is very stable, whereas the ADP-free form of conventional kinesins is labile. In the present study, the crystal structure of the novel ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka K,Umeki N,Mitsui T,Fujimoto Z,Maruta S

更新日期：2010-10-15 00:00:00