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Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors.

Abstract：

:While mutation of alpha-synuclein is a cause of autosomal-dominant Parkinson's disease (PD), it is still elusive as to how alpha-synuclein is involved in the pathogenesis of PD. Here, we show that dopamine-dependent accumulation of alpha-synuclein in cultured cells results in apoptosis. Furthermore, activation of insulin-like growth factor 1 (IGF-1) pathway can rescue alpha-synuclein toxicity and suppress alpha-synuclein aggregation through the activation of PI3K/Akt pathways. These results suggest the therapeutic potential of IGF-1 pathway in Parkinson disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kao SY

doi

10.1016/j.bbrc.2009.05.089

subject

Has Abstract

pub_date

2009-07-31 00:00:00

pages

434-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01044-4

journal_volume

385

pub_type

杂志文章

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