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Induction of apoptosis by hemorrhagic snake venom in vascular endothelial cells.

Abstract：

:Vascular degeneration appears to play crucial roles in producing many vascular malfunctions (1-3). In order to identify specific inducers of programmed death in vascular endothelial cells (VEC), examinations were made of the effects of substances that are known to affect the vascular system by using VEC in culture (4,5). We found that hemorrhagic snake venoms induced apoptotic cell death or programmed cell death of VEC. By contrast, neurotoxic snake venoms did not induce programmed cell death but caused necrosis at much higher doses of the venoms. No effect of hemorrhagic venom was observed with many types of cultured cells other than VEC. Thus, hemorrhagic snake venom appears to be a useful tool for studies of the molecular mechanisms of vascular apoptosis. The results also suggest a possible mechanism of action of hemorrhagic snake venom on the vascular system.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Araki S,Ishida T,Yamamoto T,Kaji K,Hayashi H

doi

10.1006/bbrc.1993.1023

subject

Has Abstract

pub_date

1993-01-15 00:00:00

pages

148-53

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71023-5

journal_volume

190

pub_type

杂志文章

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