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Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes.

Abstract：

:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate cyclase with the EC50 value of 3 nM, but not phospholipase C. PTH [1-34] changed the morphology of protoplasmic type astrocytes into process-bearing ones. Thus, type I astrocytes possess PTH/PTHrP receptor that is coupled to an adenylate cyclase-activating system but not to phospholipase C.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

doi

10.1006/bbrc.1994.1555

subject

Has Abstract

pub_date

1994-04-29 00:00:00

pages

1042-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71555-5

journal_volume

200

pub_type

杂志文章

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