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Bile acids of patients with renal failure (possibility of bile acid secretion in the distal tubule).

Abstract：

:Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30.9% of the total bile acids in serum and urine of healthy subjects, respectively, 26.0% in predialysis serum of patients, and only 11.3% in dialysate of patients. The amount of bile acid sulfates in the hemodialysate converted during a 24-h period dialysis, was still smaller than that in 24-h urine of healthy subjects. We propose that the distal tubule secretes bile acid sulfates.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamaga N,Adachi K,Kohara H,Shimizu K

doi

10.1016/s0006-291x(88)80699-5

subject

Has Abstract

pub_date

1988-04-15 00:00:00

pages

197-202

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80699-5

journal_volume

152

pub_type

杂志文章

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