Abstract:
:We have purified and isolated a novel, hypotensive peptide from avian ventricular tissue. Ventricular homogenates have been shown to exhibit potent hypotensive activity in the avian and mammalian species, with little natriuresis or diuresis. Using avian mean arterial pressure (MAP) as a bioassay, we were able to purify a peptide which decreased MAP 30% in adult, female chickens. Amino acid analysis indicated that it contained 20 amino acids (including two cysteine residues), and was not similar to the amino acid composition of mammalian atrial natriuretic factors, or other known hypotensive peptides.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Barbato GF,Wideman RFdoi
10.1016/0006-291x(90)91980-7subject
Has Abstractpub_date
1990-06-29 00:00:00pages
916-20issue
3eissn
0006-291Xissn
1090-2104pii
0006-291X(90)91980-7journal_volume
169pub_type
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