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Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells.

Abstract：

:We have investigated the effects of staurosporine (STP), an inhibitor of PKC, on the expression of the HSP70 gene in human colon carcinoma HT-29 cells. Cells were heated at 45 degrees C for 15 min and incubated at 37 degrees C for up to 6 hr with or without STP. When STP (5 micrograms/ml) was added during 37 degrees C incubation, the accumulation of HSP70 mRNA was suppressed. The suppression of the mRNA accumulation was due to the decrease in initiation and elongation activity of the HSP70 gene. Our study also demonstrated that the effect of STP on the elongation and accumulation of HSP70 mRNA appeared to be selective and the drug did not influence the elongation and accumulation of the house keeping gene, beta-actin mRNA. In addition, the drug did not alter the early response of heat shock gene expression, the heat-induced HSF binding activity. These results suggest that STP affects the late response of the transcriptional regulatory system of HSP genes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Erdos G,Lee YJ

doi

10.1006/bbrc.1994.1953

subject

Has Abstract

pub_date

1994-07-15 00:00:00

pages

476-83

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(84)71953-X

journal_volume

202

pub_type

杂志文章

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