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PICOT is a molecule which binds to anamorsin.

Abstract：

:Anamorsin (AM) (also called CIAPIN-1) is a cell-death-defying factor. AM deficient mice die during late gestation; AM deficient embryos are anemic and very small compared to wild type (WT) embryos. It is thought that AM plays crucial roles in hematopoiesis and embryogenesis. To clarify the mechanisms of AM functions, we performed the yeast-two-hybrid assay to identify AM-interacting molecules; we found that PICOT (PKCθ interacting cousin of thioredoxin) preferentially bound to AM. We also showed that the N-terminal regions of both AM and PICOT were essential for their bindings and the inhibition of interaction of both molecules might lead to the cell growth retardation. Both PICOT and the yeast homolog of AM are known to be iron-sulfur proteins. The phenotype of PICOT deficient mice is very similar to that of anamorsin deficient mice; both mice are embryonic lethal. These data suggest that AM and PICOT might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito Y,Shibayama H,Tanaka H,Tanimura A,Matsumura I,Kanakura Y

doi

10.1016/j.bbrc.2011.04.033

subject

Has Abstract

pub_date

2011-05-06 00:00:00

pages

329-33

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00607-3

journal_volume

408

pub_type

杂志文章

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